Results 81 to 90 of about 362,575 (339)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease

Acta Neuropathologica Communications, 2014
Background The progressive development of Alzheimer’s disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation ...
Sonia George, Annica Rönnbäck, Gunnar K Gouras, Géraldine H Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff, Patrik Brundin   +7 more
doaj   +1 more source

The Association between Tooth Loss and Alzheimer’s Disease: a Systematic Review with Meta-Analysis of Case Control Studies

Dentistry Journal, 2019
Alzheimer’s disease is classified as a neurodegenerative condition, a heterogeneous group of illnesses characterized by the slow and progressive loss of one or more functions of the nervous system.
Mario Dioguardi, Giovanni Di Gioia, Giorgia Apollonia Caloro, Giorgia Capocasale, Khrystyna Zhurakivska, Giuseppe Troiano, Lucio Lo Russo, Lorenzo Lo Muzio   +7 more
doaj   +1 more source

Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia [PDF]

, 2004
BACKGROUND: Consumers of light-to-moderate amounts of alcohol have a lower risk of dementia and, possibly, Alzheimer disease than do abstainers. Because vascular disease may contribute to symptoms of Alzheimer disease, reduction of cerebrovascular ...
Breteler, M.M.B. (Monique), Dijk, E.J. (Ewoud) van, Duijn, C.M. (Cornelia) van, Heijer, T. (Tom) den, Hofman, A. (Albert), Koudstaal, P.J. (Peter), Prins, N.D. (Niels), Vermeer, S.E. (Sarah)   +7 more
core   +1 more source

Oral and Written Naming in Alzheimer's Disease: A Longitudinal Study [PDF]

, 2018
This research was supported by Grant PSI2015-64174-P from the Spanish ...
Cuetos Vega, Fernando, González Nosti, María, Martínez, Carmen   +2 more
core   +2 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

LD‐informed deep learning for Alzheimer's gene loci detection using WGS data

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION The exponential growth of genomic datasets necessitates advanced analytical tools to effectively identify genetic loci from large‐scale high throughput sequencing data.
Taeho Jo, Paula Bice, Kwangsik Nho, Andrew J. Saykin, Alzheimer's Disease Sequencing Project   +4 more
doaj   +1 more source

Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer′s disease

Neural Regeneration Research, 2015
Alzheimer′s disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain.
Madhuri Venigalla, Sandra Sonego, Erika Gyengesi, Gerald Münch   +3 more
doaj   +1 more source

[Anesthesia and Alzheimer disease - Current perceptions] [PDF]

, 2018
BACKGROUND AND OBJECTIVES: It has been speculated that the use of anesthetic agents may be a risk factor for the development of Alzheimer disease.
Lapa, TA, Marques, AF
core   +1 more source