Results 81 to 90 of about 5,368,097 (298)

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez, Fareshte Erani, Katherine J. Bangen, David G. Coughlin, Douglas Galasko, Kelsey R. Thomas   +5 more
wiley   +1 more source

DuAL-Net: A Dual-Network Approach for Alzheimer’s Disease Risk Prediction Using APOE-Centered Regional Whole-Genome Sequencing Data

Computational and Structural Biotechnology Journal
Alzheimer’s disease prediction using genomic data remains challenging due to the high dimensionality of whole-genome sequencing data and the complex relationships between genetic variants.
Eun Hye Lee, Taeho Jo
doaj   +1 more source

Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

EMBO Molecular Medicine, 2012
Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients.
Francesc X. Guix, Tina Wahle, Kristel Vennekens, An Snellinx, Lucía Chávez‐Gutiérrez, Gerard Ill‐Raga, Eva Ramos‐Fernandez, Cristina Guardia‐Laguarta, Alberto Lleó, Muriel Arimon, Oksana Berezovska, Francisco J. Muñoz, Carlos G. Dotti, Bart De Strooper   +13 more
doaj   +1 more source

\ufffcAt a glance 2017 : Alzheimer\u2019s Disease : promoting health and independence for an aging population

Alzheimer\u2019s disease, a type of dementia, is an irreversible, progressive brain disease that affects an estimated 5.4 million Americans. It is the sixth leading cause of death among all adults and the fifth leading cause for those aged 65 or older.he

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Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Neuropsychiatric symptom profile in neurocognitive disorders and their relationship with functional decline

Frontiers in Neurology
IntroductionNeuropsychiatric symptoms (NPS) are common in neurocognitive disorders (NCD) and are known to negatively impact patient’s functional abilities.
Carolyn W. Zhu, Carolyn W. Zhu, Carolyn W. Zhu, Lon S. Schneider, Gregory A. Elder, Gregory A. Elder, Laili Soleimani, Judith Neugroschl, Corbett Schimming, Corbett Schimming, Mary Sano, Mary Sano   +11 more
doaj   +1 more source

Computer‐assisted prediction of clinical progression in the earliest stages of AD

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Individuals with subjective cognitive decline (SCD) are at increased risk for clinical progression. We studied how combining different diagnostic tests can help to identify individuals who are likely to show clinical progression.
Hanneke F.M. Rhodius‐Meester, Hilkka Liedes, Juha Koikkalainen, Steffen Wolfsgruber, Nina Coll‐Padros, Johannes Kornhuber, Oliver Peters, Frank Jessen, Luca Kleineidam, José Luis Molinuevo, Lorena Rami, Charlotte E. Teunissen, Frederik Barkhof, Sietske A.M. Sikkes, Linda M.P. Wesselman, Rosalinde E.R. Slot, Sander C.J. Verfaillie, Philip Scheltens, Betty M. Tijms, Jyrki Lötjönen, Wiesje M. van derFlier   +20 more
doaj   +1 more source

Alzheimer's Disease International

Alzheimer's Disease International (ADI) is an umbrella group of 66 Alzheimer associations throughout the world. The ADI website provides contact information for numerous Alzheimer associations located in such nations as Brazil, Iceland, Singapore ...

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Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Insights and recommendations for working collaboratively and improving care in Alzheimer's disease: Learnings from the Finding Alzheimer's Solutions Together (F.A.S.T.) Council

Health Expectations
Background Collaborations between patient organisations (POs) and the pharmaceutical industry can help identify and address the unmet needs of people living with a disease.
Jannice Roeser, Nikki Bayliss, Marco Blom, Ruth Croney, Lydia Lanman, Jerson Laks, Marco Lyons, Lea Proulx, Marianna Tsatali, Karin Westerlund, Jean Georges   +10 more
doaj   +1 more source