Results 91 to 100 of about 8,951,121 (298)

Migrations of yellowfin and skipjack tuna in the Eastern Pacific Ocean as determined by tagging experiments, 1952-1964 [PDF]

open access: yes, 1970
ENGLISH: Totals of 59,547 tagged yellowfin and 90,412 tagged skipjack were released during 1952-1964 throughout the range of the fishery in the eastern Pacific Ocean during that period.
Bayliff, William H., Fink, Bernard D.
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

LOS ELEMENTOS BÁSICOS PARA LA FORMULACIÓN DE POLÍTICAS CIENTÍFICAS, TECNOLÓGICAS Y DE INNOVACIÓN PARA LA COHESIÓN SOCIAL. UNA VISIÓN CTS

open access: yesRevista de Ciencias Sociales, 2017
En este artículo se discuten algunos elementos básicos para la formulación de políticas científicas, en general, para la cohesión social, desde una perspectiva de Ciencia, Tecnología y Sociedad (CTS).
Ronny Viales Hurtado
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Las lenguas de América Central y el idioma de sutiava según su documentación por Walter Lehmann

open access: yesRevista de Historia, 2015
Entre 1907 y 1909, el lingüista alemán Walter Lehmann realizó un viaje de exploración por varios países de América Central. Encargado por los museos antropológicos de Berlín, Hamburgo y Munich, el alumno de Eduard Seler buscó principalmente fuentes ...
Martin Künne
doaj  

Presentación

open access: yesRevista de Ciencias Sociales, 2017
Desde hace más de una década, el Centro de Investigaciones Históricas de América Central (cihac) de la Universidad de Costa Rica ha desarrollado el estudio de la historia ambiental de Costa Rica y de Centroamérica, en conjunto con el Posgrado ...
Ronny Viales Hurtado
doaj   +1 more source

Abrir la historia : ROBERTO Bolaño, el "Principio-­-Atlas" y los modos ficcionales de re-­-presentar la historia literaria [PDF]

open access: yes, 2013
La literatura de Roberto Bolaño puede ser leída como emblema de un tipo ficción capaz de ofrecer formas heterodoxas de disrupción de los discursos clásicos de organización de la historia y de la historia literaria.
Schmukler, Enrique
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Occurrence of Aflatoxin M1 in cow milk in El Salvador: Results from a two-year survey

open access: yesToxicology Reports, 2018
Aflatoxin M1 (AFM1) is a metabolite of Aflatoxin B1 (AFB1) and is excreted through cow´s milk. AFM1 contamination of milk is extended geographically and there might be seasons-related variations for both prevalence and contents, with higher than average ...
Oscar Peña-Rodas   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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