Results 81 to 90 of about 159,730 (246)
Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance
Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2011 El documento aprobado el 28 de septiembre de 2011 en la Universidad Especializada de las Américas crea la Maestría en Tecnología de la Información y la Comunicación Aplicadas a la ...
Universidad Especializada de las Américas
core +1 more source
Memoria Institucional de la Universidad Especialiada de las Américas [PDF]
, 2022 El año 2022 fue un período de relativa estabilidad para el país. Se disminuyó el índice de contagios del COVID-19, mejoró la economía y el desempleo alcanzó un dígito.
Universidad Especializada de las Américas
core +1 more source
, 2011 La realización de un sueño: en la aurora del décimo tercer año de su fundación, la Universidad Especializada de las Américas (UDELAS)muestra que los principios originarios que le dieron vida a su proyecto presentan actualmente frutos evidentes en la ...
Universidad Especializada de las Américas, UDELAS
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
, 2020 Que mediante Acuerdo del Consejo Técnico de Administración No. 001-2008 de 12 de junio de 2008, se aprobó el actual Estatuto Orgánico de la Universidad Especializada de las Américas (UDELAS); instrumento que después de 13 años requiere ser actualizado ...
Universidad Especializada de las Américas
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source