Results 11 to 20 of about 20,302 (212)

Starburst amacrine cells amplify optogenetic visual restoration through gap junctions

Molecular Therapy: Methods & Clinical Development, 2023
Ectopic induction of optogenetic actuators, such as channelrhodopsin, is a promising approach to restoring vision in the degenerating retina. However, the cell type-specific response of ectopic photoreception has not been well understood.
Yusaku Katada, Hiromitsu Kunimi, Naho Serizawa, Deokho Lee, Kenta Kobayashi, Kazuno Negishi, Hideyuki Okano, Kenji F. Tanaka, Kazuo Tsubota, Toshihide Kurihara   +9 more
doaj   +1 more source

Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury

Neural Regeneration Research, 2023
[INLINE:1] Vision depends on accurate signal conduction from the retina to the brain through the optic nerve, an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.
Zhe Liu, Jingfei Xue, Canying Liu, Jiahui Tang, Siting Wu, Jicheng Lin, Jiaxu Han, Qi Zhang, Caiqing Wu, Haishun Huang, Ling Zhao, Yehong Zhuo, Yiqing Li   +12 more
doaj   +1 more source

Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias

Scientific Reports, 2023
Stage II cholinergic retinal waves are one of the first instances of neural activity in the visual system as they are present at a developmental timepoint in which light-evoked activity remains largely undetectable.
Matthew J. Tarchick, Dustin A. Clute, Jordan M. Renna   +2 more
doaj   +1 more source

Attenuation of Oxygen-Induced Neovascularization and Inflammation by Neutralizing VEGFA and/or ANG-2 With an Antibody. [PDF]

Genes Cells
The effects of intraocular administration of neutralizing antibodies against VEGFA, ANG‐2, or bispecific to these two factors on pathological findings were examined in the oxygen‐induced retinopathy (OIR) mouse model. The antibody to VEGFA or ANG‐2 attenuated oxygen‐induced neovascularization and inflammation, and the bispecific antibody more ...
Oohashi H, Iwagawa T, Abe H, Kawaji C, Inokuchi Y, Soeda T, Saita K, Aihara M, Watanabe S.   +8 more
europepmc   +2 more sources

The effects of immune protein CD3ζ development and degeneration of retinal neurons after optic nerve injury. [PDF]

PLoS ONE, 2017
Major histocompatibility complex (MHC) class I molecules and their receptors play fundamental roles in neuronal death during diseases. T-cell receptors (TCR) function as MHCI receptor on T-cells and both MHCI and a key component of TCR, CD3ζ, are ...
Tao He, Xavier Mortensen, Ping Wang, Ning Tian   +3 more
doaj   +1 more source

Optogenetic targeting of AII amacrine cells restores retinal computations performed by the inner retina

Molecular Therapy: Methods & Clinical Development, 2023
Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of inner retinal neurons is a promising avenue to restore vision in retinas having lost their ...
Hanen Khabou, Elaine Orendorff, Francesco Trapani, Marco Rucli, Melissa Desrosiers, Pierre Yger, Deniz Dalkara, Olivier Marre   +7 more
doaj   +1 more source

Prox1 Is a Marker for AII Amacrine Cells in the Mouse Retina

Frontiers in Neuroanatomy, 2017
The transcription factor Prox1 is expressed in multiple cells in the retina during eye development. This study has focused on neuronal Prox1 expression in the inner nuclear layer (INL) of the adult mouse retina.
Luis Pérez de Sevilla Müller, Shaghauyegh S. Azar, Janira de los Santos, Nicholas C. Brecha, Nicholas C. Brecha, Nicholas C. Brecha, Nicholas C. Brecha   +6 more
doaj   +1 more source

Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients

Translational Neurodegeneration, 2023
Background The main clinical symptoms characteristic of Parkinson’s disease (PD) are bradykinesia, tremor, and other motor deficits. However, non-motor symptoms, such as visual disturbances, can be identified at early stages of the disease.
Xavier Sánchez-Sáez, Isabel Ortuño-Lizarán, Carla Sánchez-Castillo, Pedro Lax, Nicolás Cuenca   +4 more
doaj   +1 more source

Regional Variation of Gap Junctional Connections in the Mammalian Inner Retina

Cells, 2021
The retinas of many species show regional specialisations that are evident in the differences in the processing of visual input from different parts of the visual field.
Katalin Fusz, Tamás Kovács-Öller, Péter Kóbor, Edina Szabó-Meleg, Béla Völgyi, Péter Buzás, Ildikó Telkes   +6 more
doaj   +1 more source

RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. [PDF]

, 2015
A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions.
Berson, David M, Elsaesser, Rebecca, Güler, Ali D, Hattar, Samer, Montell, Craig, Rupp, Alan, Sheng, Wenlong, Walker, Marquis T, Weng, Shijun   +8 more
core   +2 more sources