Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients [PDF]
Translational Neurodegeneration, 2023 Background The main clinical symptoms characteristic of Parkinson’s disease (PD) are bradykinesia, tremor, and other motor deficits. However, non-motor symptoms, such as visual disturbances, can be identified at early stages of the disease.
Xavier Sánchez-Sáez +4 more
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Starburst amacrine cells amplify optogenetic visual restoration through gap junctions [PDF]
Molecular Therapy: Methods & Clinical Development, 2023 Ectopic induction of optogenetic actuators, such as channelrhodopsin, is a promising approach to restoring vision in the degenerating retina. However, the cell type-specific response of ectopic photoreception has not been well understood.
Yusaku Katada +9 more
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Functional properties of GABAA receptors of AII amacrine cells of the rat retina [PDF]
Frontiers in Ophthalmology, 2023 Amacrine cells are a highly diverse group of inhibitory retinal interneurons that sculpt the responses of bipolar cells, ganglion cells, and other amacrine cells.
Pablo Beltrán-Matas +2 more
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Optogenetic targeting of AII amacrine cells restores retinal computations performed by the inner retina [PDF]
Molecular Therapy: Methods & Clinical Development, 2023 Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of inner retinal neurons is a promising avenue to restore vision in retinas having lost their ...
Hanen Khabou +7 more
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A comprehensive study of c-Kit–expressing amacrine cells in the mammalian retina [PDF]
Scientific ReportsAmacrine cells assemble complex circuits in the inner retina, where they integrate, modulate, and relay spatial and temporal information to retinal ganglion cells.
Zheng Jiang, Wen Shen
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Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury [PDF]
Neural Regeneration Research, 2023 [INLINE:1] Vision depends on accurate signal conduction from the retina to the brain through the optic nerve, an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.
Zhe Liu +12 more
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Presynaptic depolarization differentially regulates dual neurotransmitter release from starburst amacrine cells in the mouse retina [PDF]
Frontiers in Ophthalmology, 2023 The retina is comprised of diverse neural networks, signaling from photoreceptors to ganglion cells to encode images. The synaptic connections between these retinal neurons are crucial points for information transfer; however, the input-output relations ...
Tomomi Ichinose +2 more
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Modeling cholinergic retinal waves: starburst amacrine cells shape wave generation, propagation, and direction bias [PDF]
Scientific Reports, 2023 Stage II cholinergic retinal waves are one of the first instances of neural activity in the visual system as they are present at a developmental timepoint in which light-evoked activity remains largely undetectable.
Matthew J. Tarchick +2 more
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Biotin-cGMP and -cAMP are able to permeate through the gap junctions of some amacrine cells in the mouse retina despite their large size [PDF]
Frontiers in Ophthalmology, 2023 Gap junctions transmit electrical signals in neurons and serve metabolic coupling and chemical communication. Gap junctions are made of intercellular channels with large pores, allowing ions and small molecules to permeate.
Chunxu Yuan +6 more
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Prox1 Is a Marker for AII Amacrine Cells in the Mouse Retina
Frontiers in Neuroanatomy, 2017 The transcription factor Prox1 is expressed in multiple cells in the retina during eye development. This study has focused on neuronal Prox1 expression in the inner nuclear layer (INL) of the adult mouse retina.
Luis Pérez de Sevilla Müller +6 more
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