Results 91 to 100 of about 18,186 (211)

Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak Control

Canadian Journal of Infectious Diseases, 2001
BACKGROUND: Amantadine, an antiviral agent, is the only drug currently approved in Canada for prophylaxis of influenza A virus infection. To minimize side effects, the amantadine dose is adjusted for age and estimated creatinine clearance (CrCl) based on
Jane A Buxton, Danuta M Skowronski, Helen Ng, Steve A Marion, Michele Williams, Anna Forbes, Arlene King, Jamie Hockin   +7 more
doaj   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

Amantadine-induced bilateral corneal edema: A case report and literature review

Indian Journal of Ophthalmology. Case Reports
We report a case of amantadine-induced bilateral corneal edema that was initially suspected as herpes simplex keratitis in a 47-year-old female patient taking amantadine for neurological disease.
Ching-Liang Kuo
doaj   +1 more source

Comparison of the effects of amantadine and ondansetron in treatment of fatigue in patients with multiple sclerosis

Clinical and Translational Medicine, 2019
Background Multiple sclerosis (MS) is a common neurological disorder with a variety of manifestations including fatigue. Fatigue may interfere with daily work and activities.
Mojtaba Khazaei, Ashkan Karevan, Mohammad Taheri, Soudeh Ghafouri-Fard   +3 more
doaj   +1 more source

Involvement of the sigma 1 receptor in the modulation of dopaminergic transmission by amantadine.

, 2004
Pharmacological effects of amantadine on dopaminergic transmission are proposed to result from an uncompetitive antagonism at glutamate N-methyl-D-aspartate (NMDA) receptors.
Maloteaux, Jean-Marie, Hermans, Emmanuel, Peeters, Magali, Su, Tsung-Ping, Maurice, Tangui, Romieu, Pascal   +5 more
core   +1 more source

PLoS One [PDF]

Widespread resistance among circulating influenza A strains to at least one of the anti-influenza drugs is a major public health concern. A triple combination antiviral drug (TCAD) regimen comprised of amantadine, oseltamivir, and ribavirin has been ...

core  

Functional characterization of amantadine sensitivity.

, 2013
A, Current traces at +40 mV and −140 mV in the absence (black) and presence (grey) of 10 mM amantadine for Kcv, Kcv*, and Kcv T63S. B, Comparison of the relative amantadine dissociation constants at +40 mV (2±0.2, wt; 22.4±1.4 Kcv*, 20.5±1.7 T63S) and ...
Courtney Domigan (369903), Carlos Pantoja (369905), Sabrina Gazzarrini (369900), Giuseppina Ferrara (369904), Anna Moroni (159454), Daniel L. Minor Jr. (369906), Yuichiro Fujiwara (369901), Franck C. Chatelain (369898), Gerhard Thiel (105643), Cristina Arrigoni (369902)   +9 more
core   +1 more source

Use of amantadine in traumatic brain injury: an updated meta-analysis of randomized controlled trials

Frontiers in Neurology
IntroductionAmantadine has been shown to accelerate cognitive and functional brain recovery after cerebrovascular accidents. However, the efficacy of this drug in TBI patients remains poorly defined.MethodsWe performed a systematic review and meta ...
João Félix, Luísa Araújo, Antônio Henriques, Ana Pereira, Saul Carneiro   +4 more
doaj   +1 more source

Amantadine use in the French prospective NS-Park cohort

International audienceObjective: To assess amantadine use and associated factors in the patients with Parkinson's disease (PD).Background: Immediate-release amantadine is approved for the treatment of PD and is largely used in clinical practice to treat "
Guehl, Pr Dominique, David, Elodie, Fraix, Valérie, Bereau, Matthieu, Corbille, Anne-Gaelle, Houvenaghel, Jean-François, Laurencin, Chloé, Damier, Philippe, Chaigneau, Véronique, Courtin, Thomas, Chevanne, Damien, Magnin, Eloi, Schneider, Vincent, Grebent, Pascale, Pelissier, Pierre, Burbaud, Pr Pierre, Vergnet, Sylvain, Puisieux, Salomé, De Rycke, Yann, Foucard, Cendrine, Lanore, Aymeric, Azulay, Jean-Philippe, Rousseau, Vanessa, Alecu, Cosmin, Julie, Céline, Corvol, Jean-Christophe, Hartmann, Andreas, Villars, Sandrine, Fabbri, Margherita, Leh, Frederique, Kistner, Andrea, Nouira, Manel, Kestens, Françoise, Lopez-Alfaro, Sandra, Benatru, Isabelle, Gravier, Alban, Rummel, Hugo, Mangone, Graziella, Vidhaillet, Marie, Beal, Charlotte, Menon, Poornima, Boudjema, Noel, Bernard, Stephane, Foucaran, Elsa, Dongmo-Kenfack, Carole, Drapier, Sophie, Picot, Marie-Christine, Causel, Astrid, Lagha-Boukbiza, Ouhaid, Bertille, Nathalie, Bendetowicz, David, Catala, Hélène, Boraud, Thomas, Mitterle, Marie-Pierre, Castelnovo, Giovanni, Gillet, Claudia, Lobstein, Aurette, Meoni, Sara, Ory-Magne, Fabienne, Debilly, Bérengère, Verna, Claudia, Maltête, David, Cormier-Dequaire, Florence, Vernon, Linda, Frismand, Solène, Dormeuil, Alice, Carriere, Nicolas, Le, Mickael, de Maindreville, Anne Doe, Clement, Guillemette, Gaudin, Thomas, Sommet, Agnès, Rascol, Olivier, Sambin, Sara, Flamand-Roze, Emmanuel, Meissner, Wassilios, Laurens, Brice, Heraud, Charlotte, Leung, Clemence, Gaiffe, Emilie, Rieu, Isabelle, Longato, Nadine, Mariani, Louise-Laure, Leclercq, Vincent, Costentin, Guillaume, Harroch, Estelle, Castrioto, Anna, Liot, Sophie, Boumediene, Ahmed, Ansquer, Solène, Elbaz, Alexis, Carvalho, Stephanie, Khoury, Fouad, Lai, Wei-Ho, Thiriez, Claire, Brefel-Courbon, Christine, Garnier, Lucie, Dupont, Gwendoline, Dupouy, Sandrine, Tessier, Samuel, Gourhan, Rozenn, Tir, Melissa, Salhi, Hayet, Garsault, Corinne, Jardel, Amory, Fra, Leslie, Bonnaire-Verdier, Margaux, Danaila, Teodor, Ferrier, Vanessa, Houeto, Jean Luc, Thobois, Stéphane, Moro, Elena, de Verdal, Marie, Bourdonnais, Christine, Philips, Clélie, Degos, Bertrand, Bras, Stéphanie, Tubach, Florence, Geny, Christian, Beauzor, Florence, Marques, Ana, Reuther, Caroline Giordana, von Raison, Florian, Bari, Rachida, Defebvre, Luc, Eusebio, Alexandre, Charif, Mahmoud, Messar, Sonia, Remy, Philippe, Frenais, Régis, Meneret, Aurélie, Le Dily, Séverine, Brefel Courbon, Christine, Derkinderen, Pascal, Hainque, Elodie, Grabli, David, Le Monnier, Lili, Aubignat, Mickael, Rabois, Emilie, Fluchere, Frédérique, Palpacuer, Thomas, Boutet, Pierre, Foubert-Samier, Alexandra, Hopes, Lucie, Rouaud, Tiphaine, Caire, Catherine, Petit, Aimée, Chaigneau, Rachel, Prange, Stephane, Selvarasa, Yajiththa, Durand, Elodie, Delorme, Cécile, Leclercq, Marion, Santraine, Valérie, Alexandre, Mélanie, Derost, Philippe, SAMIER FOUBERT, Alexandra, MEISSNER, Wassilios G   +157 more
core   +1 more source

A Secondary Gate As a Mechanism for Inhibition of the M2 Proton Channel by Amantadine

, 2016
The mechanism of inhibition of the influenza A virus M2 proton channel by the antiviral drug amantadine has been under intense investigation. The importance of a mechanistic understanding is heightened by the prevalence of amantadine-resistant mutations.
Timothy A. Cross (1316430), Huan-Xiang Zhou (9526), Myunggi Yi (2430919)   +2 more
core   +1 more source