Results 11 to 20 of about 358 (125)

GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis [PDF]

PLoS ONE, 2011
Angiogenesis and cancer invasiveness greatly contribute to cancer malignancy.Arf6 and its effector, AMAP1, are frequently overexpressed in breast cancer, and constitute a central pathway to induce the invasion and metastasis.
Toshi Menju, Ari Hashimoto, Hirokazu Kotani   +2 more
exaly   +9 more sources

Co-Overexpression of GEP100 and AMAP1 Proteins Correlates with Rapid Local Recurrence after Breast Conservative Therapy [PDF]

PLoS ONE, 2013
A major problem of current cancer research and therapy is prediction of tumor recurrence after initial treatment, rather than the simple biological characterization of the malignancy and proliferative properties of tumors.
Yoichi M Itô, Ari Hashimoto, Shinichi Shimizu   +2 more
exaly   +9 more sources

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe [PDF]

Nature Communications, 2018
Mitochondria subcellular localization is dynamically regulated during migration. Here, the authors show that Arf6–AMAP1 dependent ILK localization at focal adhesions reduces mitochondrial retrograde trafficking in migratory cells and prevents ...
Yasuhito Onodera, Jin-Min Nam, Mei Horikawa, Hiroki Shirato, Hisataka Sabe   +4 more
doaj   +3 more sources

Retraction: Oncological effects and prognostic value of AMAP1 in gastric cancer [PDF]

Frontiers in Genetics
Frontiers Editorial Office
doaj   +3 more sources

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance Pancreatic ductal carcinomas (PDACs) have been extensively studied regarding their genomic alterations, microenvironmental intercommunication, and metabolic reprogramming. However, identification of the protein machinery of tumor cells that eventually drives malignancy as a result of driver mutations, and their associated
Hashimoto S, Furukawa S, Hashimoto A, Tsutaho A, Fukao A, Sakamura Y, Parajuli G, Onodera Y, Otsuka Y, Handa H, Oikawa T, Hata S, Nishikawa Y, Mizukami Y, Kodama Y, Murakami M, Fujiwara T, Hirano S, Sabe H.   +18 more
europepmc   +7 more sources

Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination. [PDF]

Adv Sci (Weinh), 2023
An integrative ubiquitinome and proteome analysis demonstrates that the non‐degradative ubiquitination of several GTPases is regulated by mechano‐signaling. Spatial analysis reveals RAP1 ubiquitination specifically in the descending aorta, a region exposed to laminar shear stress.
Sewduth RN, Carai P, Ivanisevic T, Zhang M, Jang H, Lechat B, Van Haver D, Impens F, Nussinov R, Jones E, Sablina A.   +10 more
europepmc   +2 more sources

Effects of O2/CO2 active modified atmosphere packaging on storage quality and microstructure of postharvest truffles

Shipin yu jixie, 2022
Objective: To find a new and effective fresh storage method for truffles. Methods: Set 80% O2+20% CO2 （AMAP1）, 60% O2+40% CO2 （AMAP2）, 40% O2+60% CO2 （AMAP3）, 10% O2+90% CO2 （AMAP4） 4 air-conditioned groups and a control group of natural air without ...
JIANG Fang-guo, HU Hai-yang, GONG Xiao-yuan, LIU Jie, LI Xiang   +4 more
doaj   +2 more sources

Strain-Specific Safety Evaluation of <i>Akkermansia muciniphila</i> Akk11: Comprehensive Genotypic, Phenotypic, and Toxicological Assessment. [PDF]

Food Sci Nutr
Akkermansia muciniphila Akk11 showed strain‐specific safety: 98.36% genomic similarity to the type strain, with no mobile elements, no harmful metabolites, strong simulated GI tolerance, and no Caco‐2 cytotoxicity. Acute, reverse‐mutation, micronucleus, and 90‐day studies found no adverse effects; NOAEL was 9 × 1011 AFU/kg/day using a lyophilized ...
Wang X, Fan Y, Dong Y, Zhang Y, Tan X, Gai Z, Sun Y, Fang S.   +7 more
europepmc   +2 more sources

Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. [PDF]

PLoS ONE, 2013
The lysyl oxidase gene inhibits Ras signaling in transformed fibroblasts and breast cancer cells. Its activity was mapped to the 162 amino acid propeptide domain (LOX-PP) of the lysyl oxidase precursor protein.
Seiichi Sato, Yingshe Zhao, Misa Imai, Philip C Simister, Stephan M Feller, Philip C Trackman, Kathrin H Kirsch, Gail E Sonenshein   +7 more
doaj   +3 more sources

CCL18‐dependent translocation of AMAP1 is critical for epithelial to mesenchymal transition in breast cancer

Journal of Cellular Physiology, 2017
AMAP1 was a GTPase‐activating protein that regulates cytoskeletal structures in focal adhesions, circular dorsal ruffles, and promote cell differentiation in tumor cells. But the activation and function of AMAP1 in breast cancer remain largely unexplored. Here we show that AMAP1 was phosphorylated and translocated to plasma membrane and formed a stable
Haiyan Li, Dawei Zhang, Jiandong Yu, Hailing Liu, Zhiping Chen, Haifeng Zhong, Yunle Wan   +6 more
openaire   +3 more sources