Results 21 to 30 of about 358 (125)

Additional file 1: of Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells

, 2018
Figure S1. Correlation diagrams between each miRNA and AMAP1. Correlation diagrams between expression levels of miRNAs shown in Fig. 2b and AMAP1 mRNA. Correlation diagrams of miR-96, miR-182, and miR-301a are shown in Fig. 2c. (PDF 1029â kb)
Handa, Haruka, Hashimoto, Ari, Hashimoto, Shigeru, Sugino, Hirokazu, Oikawa, Tsukasa, Sabe, Hisataka   +5 more
openaire   +2 more sources

ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity. [PDF]

Int J Mol Sci, 2023
Despite the “big data” on cancer from recent breakthroughs in high-throughput technology and the development of new therapeutic modalities, it remains unclear as to how intra-tumor heterogeneity and phenotypic plasticity created by various ...
Hashimoto A, Hashimoto S.
europepmc   +2 more sources

Inhibition of epithelial–mesenchymal transition by cetuximab via the EGFR‐GEP100‐Arf6‐AMAP1 pathway in head and neck cancer

Head & Neck, 2016
AbstractBackgroundDespite improved survival by the addition of a monoclonal antibody against epidermal growth factor receptor (EGFR), cetuximab, to chemotherapy or radiotherapy for squamous cell carcinoma of the head and neck (SCCHN), cetuximab by itself is not a potent antiproliferative agent against SCCHN.
Yoshifumi, Matsumoto, Hiroyuki, Sakurai, Yasunao, Kogashiwa, Toru, Kimura, Yuma, Matsumoto, Takashi, Shionome, Masatake, Asano, Koichiro, Saito, Naoyuki, Kohno   +8 more
openaire   +3 more sources

Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population

Journal of Immunology Research, Volume 2022, Issue 1, 2022., 2022
Tuberculosis (TB) remains one of the deadliest infectious diseases in the world. Previous genome‐wide association studies suggested that single‐nucleotide polymorphisms (SNPs) in some genes could indicate the susceptibility to TB in some populations. Herein, we studied the association of SNPs in the immunity‐related genes, i.e., ASAP1 and SP110 genes ...
Xiaogang Cui, Tianqi Yuan, Pengyuan Ning, Jie Han, Yue Liu, Jiao Feng, Fan Lian, Mingyuan Hao, Li Dong, Jinqi Hao, Li Xing, Changxin Wu, Cinzia Ciccacci   +12 more
wiley   +1 more source

The EGFR‐GEP100‐Arf6‐AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis^† [PDF]

Traffic, 2009
Tumors are tissue‐specific diseases, and their mechanisms of invasion and metastasis are highly diverse. In breast cancer, biomarkers that specifically correlate with the invasive phenotypes have not been clearly identified. A small GTPase Arf6 primarily regulates recycling of plasma membrane components. We have shown that Arf6 and its effector AMAP1 (
Sabe, Hisataka, Hashimoto, Shigeru, Morishige, Masaki, Ogawa, Eiji, Hashimoto, Ari, Nam, Jin-Min, Miura, Koichi, Yano, Hajime, Onodera, Yasuhito   +8 more
openaire   +2 more sources

Targeting der kleinen GTPasen über ihre regulatorischen Proteine

Angewandte Chemie, Volume 132, Issue 16, Page 6402-6428, April 16, 2020., 2020
Kleine GTPasen sind schwierige Zielstrukturen für niedermolekulare und biologische Therapeutika. Dieser Aufsatz stellt Moleküle vor, die auf die regulatorischen Proteine GEF, GAP und GDI der GTPase abzielen, und identifiziert die Herausforderungen in den chemischen Strategien, einschließlich PAINs‐Motive, unzureichende Potenz und Mangel an Selektivität.
Janine L. Gray, Frank von Delft, Paul E. Brennan   +2 more
wiley   +1 more source

Targeting the Small GTPase Superfamily through Their Regulatory Proteins

Angewandte Chemie International Edition, Volume 59, Issue 16, Page 6342-6366, April 16, 2020., 2020
What a PAIN: Small GTPases have been notoriously difficult targets for small molecule and biologic therapeutics. This review explores the molecules targeting the GEF, GAP, and GDI GTPase regulatory proteins. It identifies issues in the chemical strategies, including PAINs motifs, insufficient potency, and lack of selectivity, whilst also providing ...
Janine L. Gray, Frank von Delft, Paul E. Brennan   +2 more
wiley   +1 more source

ARF6-AMAP1 pathway induces pancreatic cancer cells to express immunosuppressive chemokines

, 2022
Abstract Aim: The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is highly immune suppressive with modest T-cell infiltration, and only rarely responds to immune checkpoint inhibition (ICI) therapy. Our aim was to clarify the molecular basis underlying the immune suppressive properties of PDAC.Background: Mutations in ...
Ari Hashimoto, Haruka Handa, Soichiro Hata, Daisuke Okuzaki, Yoshizuki Fumoto, Kanon Kuroda, Akio Tsutaho, Yoshihiro Nishikawa, Yuzo Kodama, Satoshi Hirano, Shigeru Hashimoto, Hisataka Sabe   +11 more
openaire   +1 more source

EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2

Cell Biology International, Volume 44, Issue 1, Page 2-13, January 2020., 2020
Abstract Proline‐rich tyrosine kinase 2 (Pyk2) is a member of focal adhesion kinase (FAK) non‐receptor tyrosine kinase family and has been found to promote cancer cell survival, proliferation, migration, invasion, and metastasis. Pyk2 takes part in different carcinogenic signaling pathways to promote cancer progression, including epidermal growth ...
Ting Shen, Qiang Guo
wiley   +1 more source

ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance. [PDF]

Oncogenesis, 2016
Onset of the cancer mesenchymal program is closely associated with cancer malignancy and drug resistance. Among the different epithelial-mesenchymal transition (EMT)-associated transcriptional factors, ZEB1 has a key role in inducing the mesenchymal ...
Hashimoto A, Hashimoto S, Sugino H, Yoshikawa A, Onodera Y, Handa H, Oikawa T, Sabe H.   +7 more
europepmc   +2 more sources