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International Scholarly Research Notices, 2012 This paper presents a comprehensive review of amatoxin poisoning. The paper discusses the biochemistry of amatoxin, as well as the clinical manifestations of amatoxin ingestion. In addition, the evaluation of the patient with amatoxin ingestion is discussed, along with the treatment—including newer therapy—and the ultimate prognosis of the syndrome.
Bobby Desai, Brandon Allen
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Scandinavian Journal of Urology and Nephrology, 1990
Ingestion of mushrooms followed after 6-12 hours by gastrointestinal symptoms and after 3-4 days by hepatic symptoms is diagnostic for the life-threatening amatoxin intoxication and should be treated as soon as possible. Four case histories are reported and recommendations for treatment are given.
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Ingestion of mushrooms followed after 6-12 hours by gastrointestinal symptoms and after 3-4 days by hepatic symptoms is diagnostic for the life-threatening amatoxin intoxication and should be treated as soon as possible. Four case histories are reported and recommendations for treatment are given.
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Toxicokinetics of labeled amatoxins in the dog
Archives of Toxicology, 1985Radioactivities were measured in serum, urine, and bile of dogs at different times after intravenous injection of 14C-methyl-gamma-amanitin (14C-A) and 3H-O-methyl-dehydroxymethyl-alpha-amanitin (3H-A). For either substance, the relation between the specific plasma activity C and the time t could be best described with the function C = C1 X e- lambda 1
Faulstich, H., Talas, A., Wellhöner, H.
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Toxicon, 1987
A novel approach for the production of [125I]amatoxin and anti-amanitin is described. The antigen and the starting material for Bolton Hunter iodination is prepared by periodic acid oxidation of the gamma-delta-dihydroxy-isoleucine side chain of alpha-amanitin followed by reductive amination. The antigen seems to be of low apparent toxicity.
Andres, Roger Y., Frei, Werner
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A novel approach for the production of [125I]amatoxin and anti-amanitin is described. The antigen and the starting material for Bolton Hunter iodination is prepared by periodic acid oxidation of the gamma-delta-dihydroxy-isoleucine side chain of alpha-amanitin followed by reductive amination. The antigen seems to be of low apparent toxicity.
Andres, Roger Y., Frei, Werner
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Amatoxine und Knollenbl�tterpilzvergiftung
Naturwissenschaften, 1979Amatoxins are the sole cause of human Amanita poisoning, inhibition of transcription eventually leading to cell necrosis. The toxins are easily excreted into the bile fluid, a fact which postulates the interruption of the enterohepatic circulation. All therapeutic means should be applied in order to decrease the serum concentration of the toxins as ...
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Amatoxins in wood-rottingGalerina marginata
Mycologia, 2004Amatoxins, bicyclic octapeptide derivatives responsible for severe hepatic failure, are present in several Basidiomycota species belonging to four genera, i.e. Amanita, Conocybe, Galerina and Lepiota. DNA studies for G. autumnalis, G. marginata, G. oregonensis, G. unicolor and G.
Enjalbert, Françoise +4 more
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Mushrooms, amatoxins and the liver
Journal of Hepatology, 2005Acute liver failure (ALF) due to mushrooms containing amatoxins is relatively rare. In a survey of ALF in Spain, only 10 out of 267 cases (4%) were caused by amatoxins (pending publication). Amatoxin poisoning is a world wide problem: 50–100 fatal cases are reported yearly in Western Europe, being less common in the United States with fewer than 100 ...
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Comment on N-acetylcysteine as a treatment for amatoxin poisoning
Clinical Toxicology, 2020To the Editor Optimal treatment of amatoxin-related mushroom poisoning is limited by a paucity of high quality evidence.
Matthew, Correia, B Z, Horowitz
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Effects of interrupting the enterohepatic circulation in amatoxin intoxications
Clinical ToxicologyInterruption of the enterohepatic circulation is regarded as an effective way to treat patients with amatoxin poisoning. Nonetheless, its effectiveness has not yet been systematically evaluated. Therefore, we performed a systematic review to investigate the role of enterohepatic circulation on patient outcome and clinical laboratory values.
Daniel Touw +2 more
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