Results 1 to 10 of about 5,305 (247)

Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells [PDF]

Stem Cell Research & Therapy
Background Ameloblasts present a promising avenue for the investigation of enamel and tooth regeneration. Previous protocols for directing the differentiation of human embryonic stem cells (hESCs) into dental epithelial (DE) cells involving the need for ...
Ximei Zhu, YiMeng Zhao, Xiaofan Bai, Qiannan Dong, Chunli Tian, Ruilin Sun, Congjuan Yan, Jianping Ruan, Zhongbo Liu, Jianghong Gao   +9 more
doaj   +3 more sources

Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement [PDF]

Scientific Reports, 2023
Enamel forming ameloblasts move away from the dentino-enamel junction and also move relative to each other to establish enamel shape during the secretory stage of enamel development.
Masashi Shin, Aya Matsushima, Jun-ichi Nagao, Yoshihiko Tanaka, Hidemitsu Harada, Koji Okabe, John D. Bartlett   +6 more
doaj   +2 more sources

The Unfolded Protein Response in Amelogenesis and Enamel Pathologies [PDF]

Frontiers in Physiology, 2017
During the secretory phase of their life-cycle, ameloblasts are highly specialized secretory cells whose role is to elaborate an extracellular matrix that ultimately confers both form and function to dental enamel, the most highly mineralized of all ...
Steven J. Brookes, Martin J. Barron, Michael J. Dixon, Jennifer Kirkham   +3 more
doaj   +7 more sources

Materials Engineering by Ameloblasts [PDF]

Journal of Dental Research, 2015
Enamel is unique. It is the only epithelial-derived mineralized tissue in mammals and has a distinct micro- and nanostructure with nanofibrous apatite crystals as building blocks. It is synthesized by a highly specialized cell, the ameloblast, which secretes matrix proteins with little homology to any other known amino acid sequence, but which is ...
Stefan Habelitz
openaire   +6 more sources

The role of the TGF-β1 signaling pathway in the process of amelogenesis [PDF]

Frontiers in Physiology
Amelogenesis is a highly regulated process involving multiple signaling pathways, among which the transforming growth factor-β1 (TGF-β1) signaling pathway plays a pivotal role in enamel formation.
Xiaoxue Ma, Yunjing Ma, Zhiyong Lin, Mei Ji   +3 more
doaj   +2 more sources

Enamelin is critical for ameloblast integrity and enamel ultrastructure formation. [PDF]

PLoS ONE, 2014
Mutations in the human enamelin gene cause autosomal dominant hypoplastic amelogenesis imperfecta in which the affected enamel is thin or absent. Study of enamelin knockout NLS-lacZ knockin mice revealed that mineralization along the distal membrane of ...
Jan C-C Hu, Yuanyuan Hu, Yuhe Lu, Charles E Smith, Rangsiyakorn Lertlam, John Timothy Wright, Cynthia Suggs, Marc D McKee, Elia Beniash, M Enamul Kabir, James P Simmer   +10 more
doaj   +7 more sources

Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells. [PDF]

PLoS ONE, 2011
To explore gene therapy strategies for amelogenesis imperfecta (AI), a human ameloblast-like cell population was established from third molars of an AI-affected patient.
Anton V Borovjagin, Juan Dong, Michael J Passineau, Changchun Ren, Ejvis Lamani, Olga A Mamaeva, Hongju Wu, Enid Keyser, Miho Murakami, Shuo Chen, Mary MacDougall   +10 more
doaj   +3 more sources

Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB) [PDF]

Frontiers in Dental Medicine, 2023
Over 90% of the U.S. adult population suffers from tooth structure loss due to caries. Most of the mineralized tooth structure is composed of dentin, a material produced and mineralized by ectomesenchyme derived cells known as odontoblasts.
Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker   +47 more
doaj   +2 more sources

Prevention of the disrupted enamel phenotype in Slc4a4-null mice using explant organ culture maintained in a living host kidney capsule. [PDF]

, 2014
Slc4a4-null mice are a model of proximal renal tubular acidosis (pRTA). Slc4a4 encodes the electrogenic sodium base transporter NBCe1 that is involved in transcellular base transport and pH regulation during amelogenesis.
Kurtz, Ira, Paine, Michael L, Wen, Xin
core   +21 more sources

Protocol for generating three-dimensional induced early ameloblasts using serum-free media and growth factors [PDF]

STAR Protocols
Summary: Adult humans cannot regenerate the enamel-forming cell type, ameloblasts. Hence, human induced pluripotent stem cell (hiPSC)-derived ameloblasts are valuable for investigating tooth development and regeneration.
Ammar Alghadeer, Anjali P. Patni, Zicong Li, Yen Chian Lim, Julie Mathieu, Hannele Ruohola-Baker   +5 more
doaj   +2 more sources