Results 1 to 10 of about 3,132 (206)

Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells [PDF]

Stem Cell Research & Therapy
Background Ameloblasts present a promising avenue for the investigation of enamel and tooth regeneration. Previous protocols for directing the differentiation of human embryonic stem cells (hESCs) into dental epithelial (DE) cells involving the need for ...
Ximei Zhu, YiMeng Zhao, Xiaofan Bai, Qiannan Dong, Chunli Tian, Ruilin Sun, Congjuan Yan, Jianping Ruan, Zhongbo Liu, Jianghong Gao   +9 more
doaj   +3 more sources

Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement [PDF]

Scientific Reports, 2023
Enamel forming ameloblasts move away from the dentino-enamel junction and also move relative to each other to establish enamel shape during the secretory stage of enamel development.
Masashi Shin, Aya Matsushima, Jun-ichi Nagao, Yoshihiko Tanaka, Hidemitsu Harada, Koji Okabe, John D. Bartlett   +6 more
doaj   +2 more sources

The role of the TGF-β1 signaling pathway in the process of amelogenesis [PDF]

Frontiers in Physiology
Amelogenesis is a highly regulated process involving multiple signaling pathways, among which the transforming growth factor-β1 (TGF-β1) signaling pathway plays a pivotal role in enamel formation.
Xiaoxue Ma, Yunjing Ma, Zhiyong Lin, Mei Ji   +3 more
doaj   +2 more sources

Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells.

PLoS ONE, 2011
To explore gene therapy strategies for amelogenesis imperfecta (AI), a human ameloblast-like cell population was established from third molars of an AI-affected patient.
Anton V Borovjagin, Juan Dong, Michael J Passineau, Changchun Ren, Ejvis Lamani, Olga A Mamaeva, Hongju Wu, Enid Keyser, Miho Murakami, Shuo Chen, Mary MacDougall   +10 more
doaj   +2 more sources

Protocol for generating three-dimensional induced early ameloblasts using serum-free media and growth factors [PDF]

STAR Protocols
Summary: Adult humans cannot regenerate the enamel-forming cell type, ameloblasts. Hence, human induced pluripotent stem cell (hiPSC)-derived ameloblasts are valuable for investigating tooth development and regeneration.
Ammar Alghadeer, Anjali P. Patni, Zicong Li, Yen Chian Lim, Julie Mathieu, Hannele Ruohola-Baker   +5 more
doaj   +2 more sources

Overexpression of ameloblastin in secretory ameloblasts results in demarcated, hypomineralized opacities in enamel. [PDF]

Front Physiol, 2023
Chun YP, Tan C, Villanueva O, Colley ME, Quintanilla TJ, Basiouny MS, Hartel CA, Critchfield CS, Bach SBH, Fajardo RJ, Pham CD.   +10 more
europepmc   +3 more sources

ADAM10 Expression by Ameloblasts Is Essential for Proper Enamel Formation. [PDF]

Int J Mol Sci
Shahid S, Hu Y, Mohamed F, Rizzotto L, Layana MC, Fleming DT, Papagerakis P, Foster BL, Simmer JP, Bartlett JD.   +9 more
europepmc   +2 more sources

Epiprofin Transcriptional Activation Promotes Ameloblast Induction From Mouse Induced Pluripotent Stem Cells via the BMP-Smad Signaling Axis

Frontiers in Bioengineering and Biotechnology, 2022
The transcriptional regulation of induced pluripotent stem cells (iPSCs) holds promise for their directed differentiation into ameloblasts, which are usually lost after tooth eruption.
Xinchao Miao, Xinchao Miao, Kunimichi Niibe, Yunyu Fu, Maolin Zhang, Maolin Zhang, Praphawi Nattasit, Yumi Ohori-Morita, Takashi Nakamura, Xinquan Jiang, Hiroshi Egusa, Hiroshi Egusa   +11 more
doaj   +1 more source

Correlation of amyloid and ameloblast‐associated proteins to odontogenic cysts and tumors: A cross‐sectional study

Health Science Reports, 2023
Background and Aims Odontogenic cysts and tumors often form hard and soft structures that resemble odontogenesis. It is well known that amyloid is produced in Pindborg tumors; however, it is still debatable whether it is also formed in other odontogenic ...
Haider H. Al‐Qazzaz, Bashar H. Abdullah, Omar S. Museedi   +2 more
doaj   +1 more source

Amelogenin and alkaline phosphatase expression in ameloblast after saltwater fish consumption in pregnant mice (Mus musculus)

Dental Journal, 2023
Background: The intricate process of tooth formation during embryonic development ensures sufficient nutrition for the growth of healthy dental tissues.
Sandy Christiono, Seno Pradopo, I Ketut Sudiana, Islamy Rahma Hutami, Regilia Shinta Mayangsari, Yayun Siti Rochmah, Zurairah Ibrahim   +6 more
doaj   +1 more source