Results 11 to 20 of about 339,266 (327)

The Use of the Ames Test as a Tool for Addressing Problem-Based Learning in the Microbiology Lab [PDF]

Journal of Microbiology & Biology Education, 2012
Our environment is full of potential carcinogens such as UV light, industrial pollutants, pesticides, and food additives, among others. It is estimated that 90% of all carcinogens are also mutagens.
Eliana Rodríguez, Claudia Piccini, Vanessa Sosa, Pablo Zunino   +3 more
doaj   +2 more sources

Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system [PDF]

Scientific Reports
The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with/without ...
Su-Min Bak, Seng-Min Back, Da Yeon Kim, Soyoung Jung, Na-Young Jeung, Nan-Young Kim, Kang-Hyun Han, Yong-Bum Kim, Byoung-Seok Lee, Jun Hong Park, Hee Jun Cho, Hee Gu Lee, Ozkan Ozden, Sang Kyum Kim, Seong-Hoon Park   +14 more
doaj   +2 more sources

Matrine and Oxymatrine: evaluating the gene mutation potential using in silico tools and the bacterial reverse mutation assay (Ames test). [PDF]

Mutagenesis, 2023
Fischer BC, Musengi Y, König J, Sachse B, Hessel-Pras S, Schäfer B, Kneuer C, Herrmann K.   +7 more
europepmc   +3 more sources

Possible Genotoxic Effects of Post-Harvest Fungicides Applied on Citrus Peels: Imazalil, Pyrimethanil, Thiabendazole and Their Mixtures [PDF]

Foods
Post-harvest fungicides are frequently used on citrus peels to reduce post-harvest fungal contamination during the storage and transport of products. Despite these positive effects, fungicides can pose health risks to consumers.
Boglárka Bernadett Tisza, Luca Járomi, Judit Háhn, Bálint Bérczi, Andrea Horváth-Sarródi, Andrea Gubicskóné Kisbenedek, Gellért Gerencsér   +6 more
doaj   +2 more sources

Studies of <i>Piper auritum</i> Kuntz's Mutagenic and Antimutagenic Properties Using the Ames Test. [PDF]

Metabolites
Muñoz-Carrillo LS, Madrigal-Bujaidar E, Hernández-Ojeda SL, Morales-González JA, Madrigal-Santillán EO, Álvarez-González I, Espinosa-Aguirre JJ.   +6 more
europepmc   +2 more sources

Progress in Predicting Ames Test Outcomes from Chemical Structures: An In-Depth Re-Evaluation of Models from the 1st and 2nd Ames/QSAR International Challenge Projects. [PDF]

Int J Mol Sci
Uesawa Y.
europepmc   +3 more sources

Risk-based in silico mutagenic assessment of benzodiazepine impurities using three QSAR tools [PDF]

Toxicology Reports
Benzodiazepines, widely prescribed psychoactive drugs, may contain DNA-reactive (mutagenic) impurities formed during synthesis, posing significant health risks.
Srinivas Birudukota, Bhaskar Mangalapu, Ramesha Andagar Ramakrishna, Swagata Halder   +3 more
doaj   +2 more sources

MUTAGENICITY OF KOJIC ACID PRODUCED FROM WILD TYPE Aspergillus oryzae [PDF]

Mesopotamia Journal of Agriculture, 2023
Kojic acid (KA) is a multipurpose natural compound, commonly used in the food and cosmetics industry. It is produced by different types of molds especially by the species Aspergillus oryzae. In this study, we test the mutagenicity of local produced kojic
Tariq Ibrahim, Salah Ahmed, Younis Younis, Michael Chikindas   +3 more
doaj   +1 more source

Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™

Genes and Environment, 2021
Background Food flavors are relatively low molecular weight chemicals with unique odor-related functional groups that may also be associated with mutagenicity. These chemicals are often difficult to test for mutagenicity by the Ames test because of their
Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata, Masamitsu Honma   +9 more
doaj   +1 more source

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS

Genes and Environment, 2021
Background Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagenicity assays using human cells are
Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura, Maya Ueda, Masayuki Mishima, Kaori Matsuzaki, Akira Takeiri, Kenji Tanaka, Yuki Okada, Munehiro Nakagawa, Shuichi Hamada, Akihiko Kajikawa, Hiroshi Honda, Jun Adachi, Kentaro Misaki, Kumiko Ogawa, Masamitsu Honma   +29 more
doaj   +1 more source