Results 11 to 20 of about 352,526 (305)

SAR Modeling to Predict Ames Mutagenicity Across Different Salmonella typhimurium Strains [PDF]

Pharmaceuticals
Background: The Ames test, a biological assay employing various strains of Salmonella typhimurium, serves as a cornerstone in genetic toxicology for evaluating the mutagenic and potentially carcinogenic properties of chemical compounds.
Alexander V. Dmitriev, Alexey A. Lagunin, Anastasia V. Rudik, Polina I. Savosina, Dmitry S. Druzhilovskiy, Dmitry A. Filimonov, Vladimir V. Poroikov   +6 more
doaj   +2 more sources

Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system [PDF]

Scientific Reports
The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with/without ...
Su-Min Bak, Seng-Min Back, Da Yeon Kim, Soyoung Jung, Na-Young Jeung, Nan-Young Kim, Kang-Hyun Han, Yong-Bum Kim, Byoung-Seok Lee, Jun Hong Park, Hee Jun Cho, Hee Gu Lee, Ozkan Ozden, Sang Kyum Kim, Seong-Hoon Park   +14 more
doaj   +2 more sources

The Use of the Ames Test as a Tool for Addressing Problem-Based Learning in the Microbiology Lab [PDF]

Journal of Microbiology & Biology Education, 2012
Our environment is full of potential carcinogens such as UV light, industrial pollutants, pesticides, and food additives, among others. It is estimated that 90% of all carcinogens are also mutagens.
Eliana Rodríguez, Claudia Piccini, Vanessa Sosa, Pablo Zunino   +3 more
doaj   +2 more sources

MUTAGENICITY OF KOJIC ACID PRODUCED FROM WILD TYPE Aspergillus oryzae [PDF]

Mesopotamia Journal of Agriculture, 2023
Kojic acid (KA) is a multipurpose natural compound, commonly used in the food and cosmetics industry. It is produced by different types of molds especially by the species Aspergillus oryzae. In this study, we test the mutagenicity of local produced kojic
Tariq Ibrahim, Salah Ahmed, Younis Younis, Michael Chikindas   +3 more
doaj   +1 more source

Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™

Genes and Environment, 2021
Background Food flavors are relatively low molecular weight chemicals with unique odor-related functional groups that may also be associated with mutagenicity. These chemicals are often difficult to test for mutagenicity by the Ames test because of their
Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata, Masamitsu Honma   +9 more
doaj   +1 more source

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS

Genes and Environment, 2021
Background Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagenicity assays using human cells are
Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura, Maya Ueda, Masayuki Mishima, Kaori Matsuzaki, Akira Takeiri, Kenji Tanaka, Yuki Okada, Munehiro Nakagawa, Shuichi Hamada, Akihiko Kajikawa, Hiroshi Honda, Jun Adachi, Kentaro Misaki, Kumiko Ogawa, Masamitsu Honma   +29 more
doaj   +1 more source

White phosphorus genotoxicity

BIO Web of Conferences, 2021
The genotoxicity of white phosphorus was previously evaluated using the Ames test, which demonstrated the absence of toxicity. However, with all the advantages of this method, the use of the Ames test has some shortfallsin assessing genotoxicity.
Mindubaev Anton, Babynin Edward, Minzanova Salima, Badeeva Elena, Akosah Yaw   +4 more
doaj   +1 more source

Mutagenicity of Chinese traditional medicine Semen Armeniacae amarum by two modified Ames tests

BMC Complementary and Alternative Medicine, 2009
Background Semen armeniacae amarum (SAA) is a Chinese traditional medicine and has long been used to control acute lower respiratory tract infection and asthma, as a result of its expectorant and antiasthmatic activities.
Cai Yupin, Tian Xiao, Zhang Hui, Liu Bo, Jin Jianling, Gao Peiji   +5 more
doaj   +1 more source

Bacterial mutagenicity test data: collection by the task force of the Japan pharmaceutical manufacturers association

Genes and Environment, 2021
Background Ames test is used worldwide for detecting the bacterial mutagenicity of chemicals. In silico analyses of bacterial mutagenicity have recently gained acceptance by regulatory agencies; however, current in silico models for prediction remain to ...
Atsushi Hakura, Takumi Awogi, Toshiyuki Shiragiku, Atsushi Ohigashi, Mika Yamamoto, Kayoko Kanasaki, Hiroaki Oka, Yasuaki Dewa, Shunsuke Ozawa, Kouji Sakamoto, Tatsuya Kato, Eiji Yamamura   +11 more
doaj   +1 more source

The ames test [PDF]

Biochemistry and Molecular Biology Education, 2003
AbstractTerms to be familiar with before you start to solve the test: Polycyclic aromatic hydrocarbons, microsomal fraction, histidine operon, mutation, induction, repression, translation, Ca2+ channel, Ca2+ ATPase, steroid receptor, cytochrome P450, cytochrome c, direct and indirect carcinogen, procarcinogen, mutagenic compounds, tumor initiation ...
openaire   +1 more source