Results 81 to 90 of about 173,620 (335)

A Peptide Nucleic Acid‐Functionalized Heterojunction Thin Film Transistor as a Scalable and Reusable Platform for Label‐Free Detection of MicroRNA

open access: yesAdvanced Functional Materials, EarlyView.
A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi   +5 more
wiley   +1 more source

Biologically Active Compounds. II. The Synthesis of β-CarboxY-γ-butyrolactone Derivatives [PDF]

open access: yes, 1968
Amide derivatives of γ-substituted paraconic and aconic acids have been synthesized. Ultraviolet spectra of the aconic acid derivatives showed characteristic fine structure in the region of 245 to 280 ...
Isikawa, Tatsuo   +2 more
core   +1 more source

Label‐Free and Low‐Power Driven Cancer Biomarker Detection Enabled by 2D Hexagonal Titanium Oxide

open access: yesAdvanced Functional Materials, EarlyView.
A low‐power driven FET biosensor based on 2D hexagonal TiO2 detects the cancer biomarker carcinoembryonic antigen with high sensitivity, a low detection limit of 0.22 pg mL−1, and excellent selectivity. Leveraging the unique electronic properties of the material, this work demonstrates strong potential for integration into miniature and portable cancer
Yange Luan   +13 more
wiley   +1 more source

Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME

open access: yesAdvanced Functional Materials, EarlyView.
A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li   +10 more
wiley   +1 more source

Characterization of the Metabolic Fate of Datura metel Seed Extract and Its Main Constituents in Rats

open access: yesFrontiers in Pharmacology, 2019
Datura metel L. has been frequently used in Chinese traditional medicine. However, little is known on the chemical composition and in vivo metabolism of its seeds.
Cong Xia   +9 more
doaj   +1 more source

Electrospun polyvinyl alcohol/carbon dioxide modified polyethyleneimine composite nanofiber scaffolds [PDF]

open access: yes, 2014
A novel biocompatible polyvinyl alcohol/carbon dioxide modified polyethyleneimine (PVA/PEI-CO2) composite nanofiber was fabricated by a green and facile protocol, which reduces the cytotoxicity of PEI through the surface modification of the PEI with CO2.
Bremner, David H.   +4 more
core   +3 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

open access: yesAdvanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz   +3 more
wiley   +1 more source

Inseminação artificial intra-uterina em leitoas com sêmen criopreservado com dimetilacetamida e glicerol Intrauterine artificial insemination of gilts using cryopreserved boar semen with dimetilacetamide and glycerol

open access: yesCiência Rural, 2008
Este estudo teve por objetivo avaliar o uso da dimetilacetamida (DMA) e de glicerol na criopreservação de sêmen suíno sobre as taxas de concepção e fertilização in vivo, utilizando o método de inseminação artificial pós-cervical.
Ivan Bianchi   +9 more
doaj   +1 more source

The Fascinating Chemistry of α‐Haloamides

open access: yesChemistryOpen, 2020
The aim of this review is to highlight the rich chemistry of α‐haloamides originally mainly used to discover new C−N, C−O and C−S bond forming reactions, and later widely employed in C−C cross‐coupling reactions with C(sp3), C(sp2) and C(sp) coupling ...
Dr. Anna Fantinati   +3 more
doaj   +1 more source

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