Results 101 to 110 of about 10,249 (213)
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.TANs drive ICI resistance via antitumour immune remodelling, angiogenesis promotion, and elevation of tumour mutation burden Neutrophil biomarkers (e.g., NLR, TAN abundance) show strong predictive value for ICI response and prognosis. Targeting TAN recruitment, polarization, function and NETosis represents a promising strategy to overcome ICI ...
Ying Ning +7 more
wiley +1 more source
Applying Green Chemistry Principles in the Electrophilic Bromination of Indole-3-Acetic Acid [PDF]
, 2014 The goals of green chemistry are to reduce or eliminate the use of hazardous reagents, prevent the synthesis of toxic products and byproducts, and improve the overall efficiency of chemical reactions.
Murphy, Kyle
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Engineering Reports, Volume 8, Issue 1, January 2026.Synergistic interaction was observed to exist between terpineol, 1,5,9‐undecatriene‐2,6,10‐trimethyl‐(Z), and hexadecanoic acid‐methyl ester present in yellow bush. Yellow bush (YB) reduced acidic corrosion of API 5 L X65 steel, achieving optimum inhibition efficiency (IE) of 77.53% at 40 ppm, 89.99 at 60 ppm from WL, EIS and Tafel plots.
Joseph Itodo Emmanuel +7 more
wiley +1 more source
3-Amino-2H-azirine, Moleküle mit vielfältigen Reaktionsmöglichkeiten
CHIMIA, 1979 3-Amino-2H-azirines, cyclic three-membered amidines with an estimated ring strain of about 200 kJ/mole, undergo a variety of reactions. Thereby, each of the azirine bonds can be broken: Thermolysis leads to the rupture of the C(2),C(3)-bond, with strong
Heinz Heimgartner
doaj +1 more source
Automated Solid Phase Synthesis of Stapled Oligopeptides as Covalent PAD4 Inhibitors
Peptide Science, Volume 118, Issue 1, January 2026.ABSTRACT We demonstrate our results with the synthesis of inhibitors of Protein Arginine Deaminase 4 (PAD4), a key regulator of neutrophil elastase extracellular traps (NETs), as potential therapeutics for chronic obstructive pulmonary disease (COPD). Furthermore, we report an automated method for solid phase synthesis of macrocyclic stapled peptides ...
Antoine Magniez +10 more
wiley +1 more source
Journal of Physical Organic Chemistry, Volume 39, Issue 1, January 2026.DFT calculations, carried out in the gas phase for all possible tautomers of 5‐aminopyrrole‐2‐amidine (APA), permit the estimation of their relative stabilities and allow the selection of energetically favored forms. All tautomers are push‐pull imino N‐bases that exhibit calculated basicities in the higher range of the current gas‐phase basicity scale.
Ewa Daniela Raczyńska +2 more
wiley +1 more source
Towards the catalytic asymmetric bromination of alkenes
, 2011 This thesis relates our efforts towards the development of a general method for the catalytic asymmetric bromination of alkenes. Previous work within the group had reported the synthesis and the use of 2,6-di-[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-
Cailleau, Thaïs, Cailleau, Thaïs
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Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components
Small Methods, Volume 10, Issue 2, 22 January 2026.The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu +6 more
wiley +1 more source
Ring transformations in reactions of pyrimidine and N-alkylpyrimidinium salts with nucleophile [PDF]
Paper IOn treatment with liquid ammonia at -33°C, the quaternary pyrimidinium salts, i.e. 1-methylpyrimidinium methyl sulfate, 1,2-dimethylpyrimidinium iodide, 1,4,6-trimethyl-pyrimidinium iodide and 1,2,4,6-tetramethylpyrimidinium iodide demethylate ...
Oostveen, E.A.
core +1 more source