Results 41 to 50 of about 6,120 (217)
Specificity and Mechanism of Mandelamide Hydrolase Catalysis [PDF]
, 2017 The best-studied amidase signature (AS) enzyme is probably fatty acid amide hydrolase (FAAH). Closely related to FAAH is mandelamide hydrolase (MAH), whose substrate specificity and mechanism of catalysis are described in this paper.
Adediran, S. A. +5 more
core +1 more source
Thiazoline-Specific Amidohydrolase PurAH Is the Gatekeeper of Bottromycin Biosynthesis [PDF]
Journal of the American Chemical Society, 2019 The ribosomally synthesized and post-translationally modified peptide (RiPP) bottromycin A2 possesses potent antimicrobial activity. Its biosynthesis involves the enzymatic formation of a macroamidine, a process previously suggested to require the concerted efforts of a YcaO enzyme (PurCD) and an amidohydrolase (PurAH) in vivo. In vitro, PurCD alone is
Asfandyar Sikandar +4 more
openaire +3 more sources
Viruses, 2018 In response to increasing concern over antibiotic-resistant Staphylococcus aureus, the development of novel antimicrobials has been called for, with bacteriophage endolysins having received considerable attention as alternatives to antibiotics.
Bokyung Son, Minsuk Kong, Sangryeol Ryu
doaj +1 more source
Auxins and cytokinins : the role of subcellular organization on homeostasis [PDF]
, 2018 Plant hormones are master regulators of plant growth and development. Better knowledge of their spatial signaling and homeostasis (transport and metabolism) on the lowest structural levels (cellular and subcellular) is therefore crucial to a better ...
Kubes, M. +3 more
core +1 more source
The structure of the hexameric atrazine chlorohydrolase AtzA
, 2015 Atrazine chlorohydrolase (AtzA) was discovered and purified in the early 1990s from soil that had been exposed to the widely used herbicide atrazine. It was subsequently found that this enzyme catalyzes the first and necessary step in the breakdown of ...
Balotra, S. +5 more
core +1 more source
MicrobiologyOpen, 2019 Here, we present a proof‐of‐principle for a new high‐throughput functional screening of metagenomic libraries for the selection of enzymes with different activities, predetermined by the substrate being used. By this approach, a total of 21 enzyme‐coding
Vida Časaitė +9 more
doaj +1 more source
Natural Language Query in the Biochemistry and Molecular Biology Domains Based on Cognition Search™ [PDF]
, 2008 Motivation: With the tremendous growth in scientific literature, it is necessary to improve upon the standard pattern matching style of the available search engines. Semantic NLP may be the solution to this problem.
Elizabeth J. Goldsmith +3 more
core +2 more sources
Diagnosis of dihydropyrimidinase deficiency in a Chinese boy with dihydropyrimidinuria [PDF]
, 2013 published_or_final_versio
Lam, CW +5 more
core +1 more source
Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source
Frontiers in Chemistry, 2014 Carrageenans are sulfated polysaccharides extracted from the cell wall of some marine red algae. These polysaccharides are widely used as gelling, stabilizing, and viscosifying agents in the food and pharmaceutical industries.
Sabine Marie Genicot +12 more
doaj +1 more source