In vitro study of bacterial amidohydrolase application in cancer therapy. [PDF]
, 2022 Despite major progress in cancer therapy developement in recent years, cancer ranks as one of the leading causes of death globally. Conventional chemotherapy drugs used in cancer therapy often lack selectivity and cause side effects to normal rapidly ...
Zubavičiūtė, Simona,
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Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile [PDF]
, 2014 Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and ...
Zoltner, Martin +3 more
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Formation and Structure of 1:1 Complexes between Aryl Hydroxamic Acids and Vanadate at Neutral pH [PDF]
, 2016 Although aryl hydroxamic acids are well-known to form coordination complexes with vanadate (VV), the nature of these complexes at neutral pH and submillimolar concentrations, the conditions under which such complexes inhibit various serine ...
Jason H. Bell (2965416) +1 more
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Skl, a novel choline-binding N-acetylmuramoyl-l-alanine amidase of Streptococcus mitis SK137 containing a CHAP domain [PDF]
, 2006 The skl gene from Streptococcus mitis SK137 encodes a peptidoglycan hydrolase (Skl) that has been purified and biochemically characterized. Analysis of the degradation products obtained by digestion of pneumococcal cell walls with Skl revealed that this ...
López, Rubens +2 more
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mBioConjugative type 4 secretion systems (T4SSs) are the main driver for the spread of antibiotic resistance genes and virulence factors in bacteria.
Wei-Sheng Sun +4 more
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A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase [PDF]
, 2018 The catalytic mechanism of the cyclic amidohydrolase isatin hydrolase depends on a catalytically active manganese in the substrate-binding pocket. The Mn$^{2+}$ ion is bound by a motif also present in other metal dependent hydrolases like the bacterial ...
Bjerregaard-Andersen, Kaare +8 more
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Inhibitory activity of Image -asparaginase from Mycobcacterium tuberculosis on Yoshida ascites sarcoma in rats [PDF]
, 1969 The antitumor activity of Image -asparagine amidohydrolases (EC 3.5.1.1) from Mycobacterium tuberculosis H37Rv and H37Ra strains has been tested on Yoshida ascites sarcoma in rats. The enzyme specific to M.
Jayaram, HN +3 more
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Helicobacter pylori L-asparaginase: A promising chemotherapeutic agent [PDF]
, 2008 Bacterial L -asparaginases are amidohydrolases that catalyse the conversion of L -asparagine to L -aspartate and ammonia and are used as anti-cancer drugs.
Cappelletti Donata +5 more
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The airway epithelium is exposed to alcohol during drinking through direct exhalation of volatized ethanol from the bronchial circulation. Alcohol exposure leads to a rapid increase in the cilia beat frequency (CBF) of bronchial epithelial cells followed
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Synthesis and biological activity of amino acid conjugates of abscisic acid. [PDF]
application/pdfWe prepared 19 amino acid conjugates of the plant hormone abscisic acid (ABA) and investigated their biological activity, enzymatic hydrolysis by a recombinant Arabidopsis amidohydrolases GST-ILR1 and GST-IAR3, and metabolic fate in rice ...
Narita, Kenta +7 more
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