Results 161 to 170 of about 170,643 (213)

Role of Epistasis in Amikacin, Kanamycin, Bedaquiline, and Clofazimine Resistance in Mycobacterium tuberculosis Complex

Antimicrobial Agents and Chemotherapy, 2021
Antibiotic resistance among bacterial pathogens poses a major global health threat. Mycobacterium tuberculosis complex (MTBC) is estimated to have the highest resistance rates of any pathogen globally.
Roger Vargas, Luca Freschi, Andrea Spitaleri   +2 more
exaly   +2 more sources

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Luminescent Sensor with High Sensitivity and Selectivity for Amikacin Detection in a Serum using a Unique Gallium-Organic Framework.

Inorganic Chemistry, 2023
Amikacin is a widely used antibiotic in the treatment of Gram-negative bacteria, but high concentrations of amikacin can cause cochlear nerve damage. Therefore, accurate and quick detection of the concentration of amikacin is desired and important.
Yao Xie, Zhuohao Jiao, Jie Dong, S. Hou, Bin Zhao   +4 more
semanticscholar   +1 more source

Amikacin Liposome Inhalation Suspension: A Review in Mycobacterium avium Complex Lung Disease

Drugs, 2019
Amikacin liposome inhalation suspension (ALIS; Arikayce®) [formerly known as liposomal amikacin for inhalation, or LAI] is a liposomal formulation of the aminoglycoside antibacterial drug amikacin.
M. Shirley
exaly   +2 more sources

Electrochemical detection of amikacin sulphate using reduced graphene oxide and silver nanoparticles nanocomposite

Applied Surface Science, 2020
This work examined the electrochemical detection of amikacin sulphate by utilizing a nano composite of green synthesized silver nanoparticles and reduced graphene oxide (AgNPs/rGO) on a nickel foam (NiF) electrode.
Sathish Panneer Selvam, Kyusik Yun
exaly   +2 more sources

GenoType NTM-DR Performance Evaluation for Identification of Mycobacterium avium Complex and Mycobacterium abscessus and Determination of Clarithromycin and Amikacin Resistance

Journal of Clinical Microbiology, 2019
We evaluated the GenoType NTM-DR (NTM-DR) line probe assay for identifying Mycobacterium avium complex (MAC) species and Mycobacterium abscessus subspecies and for determining clarithromycin and amikacin resistance. Thirty-eight reference strains and 145
Hee Jae Huh, Su-Young Kim, Hyang Jin Shim   +2 more
exaly   +2 more sources

Amikacin Liposome Inhalation Suspension for Treatment‐Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT). A Prospective, Open‐Label, Randomized Study

American Journal of Respiratory and Critical Care Medicine, 2018
Rationale: Improved therapeutic options are needed for patients with treatment‐refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex (MAC).
D. Griffith, G. Eagle, R. Thomson, T. Aksamit, N. Hasegawa, K. Morimoto, D. Addrizzo-Harris, A. O'donnell, T. Marras, P. Flume, M. Loebinger, L. Morgan, L. Codecasa, A. Hill, S. Ruoss, J. Yim, F. Ringshausen, S. Field, J. Philley, R. Wallace, J. van Ingen, C. Coulter, J. Nezamis, K. Winthrop   +23 more
semanticscholar   +1 more source

Alginate modified-PLGA nanoparticles entrapping amikacin and moxifloxacin as a novel host-directed therapy for multidrug-resistant tuberculosis

Journal of Drug Delivery Science and Technology, 2019
Polymeric nanoparticles have been widely investigated as a controlled release drug delivery platform for the treatment of tuberculosis (TB). These nanoparticles are readily internalised into macrophages and leads to high intracellular drug concentration.
Sharif Abdelghany, Ben Roediger, Hak-Kim Chan   +2 more
exaly   +2 more sources

A meta-analysis of the target trough concentration of gentamicin and amikacin for reducing the risk of nephrotoxicity.

Journal of Infection and Chemotherapy, 2020
INTRODUCTION Antimicrobial resistance is one of the biggest threats to public health systems worldwide, and aminoglycosides are key drugs for treating drug-resistant infections.
Tomoyuki Yamada, S. Fujii, A. Shigemi, Y. Takesue   +3 more
semanticscholar   +1 more source

Amikacin induces rapid dose-dependent apoptotic cell death in equine chondrocytes and synovial cells in vitro.

Equine Veterinary Journal, 2020
BACKGROUND Equine veterinarians frequently inject aminoglycoside antibiotics intra-articularly, either to treat septic arthritis or for prophylaxis with other medications when injecting joints for osteoarthritis.
L. Pezzanite, L. Chow, Sirikul Soontararak, J. Phillips, L. Goodrich, S. Dow   +5 more
semanticscholar   +1 more source

Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE): a double-blind, randomised, placebo-controlled, phase 3, superiority trial.

Lancet. Infectious Diseases (Print), 2019
BACKGROUND Treatment of ventilated pneumonia is often unsuccessful, even when patients are treated according to established guidelines. Therefore, we aimed to investigate the efficacy of the combination drug device Amikacin Inhale as an adjunctive ...
M. Niederman, J. Alder, M. Bassetti, Francis Boateng, B. Cao, K. Corkery, R. Dhand, K. Kaye, R. Lawatscheck, P. McLeroth, D. Nicolau, Chen Wang, G. Wood, R. Wunderink, J. Chastre   +14 more
semanticscholar   +1 more source