Results 211 to 220 of about 205,880 (261)

Amikacin Liposome Inhalation Suspension for Treatment‐Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT). A Prospective, Open‐Label, Randomized Study

American Journal of Respiratory and Critical Care Medicine, 2018
Rationale: Improved therapeutic options are needed for patients with treatment‐refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex (MAC).
D. Griffith, G. Eagle, R. Thomson, T. Aksamit, N. Hasegawa, K. Morimoto, D. Addrizzo-Harris, A. O'donnell, T. Marras, P. Flume, M. Loebinger, L. Morgan, L. Codecasa, A. Hill, S. Ruoss, J. Yim, F. Ringshausen, S. Field, J. Philley, R. Wallace, J. van Ingen, C. Coulter, J. Nezamis, K. Winthrop   +23 more
semanticscholar   +1 more source

A meta-analysis of the target trough concentration of gentamicin and amikacin for reducing the risk of nephrotoxicity.

Journal of Infection and Chemotherapy, 2020
INTRODUCTION Antimicrobial resistance is one of the biggest threats to public health systems worldwide, and aminoglycosides are key drugs for treating drug-resistant infections.
Tomoyuki Yamada, S. Fujii, A. Shigemi, Y. Takesue   +3 more
semanticscholar   +1 more source

AMIKACIN

Lancet, The, 1977
exaly   +4 more sources

Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE): a double-blind, randomised, placebo-controlled, phase 3, superiority trial.

Lancet. Infectious Diseases (Print), 2019
BACKGROUND Treatment of ventilated pneumonia is often unsuccessful, even when patients are treated according to established guidelines. Therefore, we aimed to investigate the efficacy of the combination drug device Amikacin Inhale as an adjunctive ...
M. Niederman, J. Alder, M. Bassetti, Francis Boateng, B. Cao, K. Corkery, R. Dhand, K. Kaye, R. Lawatscheck, P. McLeroth, D. Nicolau, Chen Wang, G. Wood, R. Wunderink, J. Chastre   +14 more
semanticscholar   +1 more source

Amikacin induces rapid dose-dependent apoptotic cell death in equine chondrocytes and synovial cells in vitro.

Equine Veterinary Journal, 2020
BACKGROUND Equine veterinarians frequently inject aminoglycoside antibiotics intra-articularly, either to treat septic arthritis or for prophylaxis with other medications when injecting joints for osteoarthritis.
L. Pezzanite, L. Chow, Sirikul Soontararak, J. Phillips, L. Goodrich, S. Dow   +5 more
semanticscholar   +1 more source

Alginate modified-PLGA nanoparticles entrapping amikacin and moxifloxacin as a novel host-directed therapy for multidrug-resistant tuberculosis

Journal of Drug Delivery Science and Technology, 2019
Polymeric nanoparticles have been widely investigated as a controlled release drug delivery platform for the treatment of tuberculosis (TB). These nanoparticles are readily internalised into macrophages and leads to high intracellular drug concentration.
Sharif Abdelghany, T. Parumasivam, A. Pang, B. Roediger, P. Tang, Kristina A. Jahn, W. Britton, H. Chan   +7 more
semanticscholar   +1 more source

Amikacin

Reactions Weekly, 2021
  +6 more sources

Eradication of persister cells of Acinetobacter baumannii through combination of colistin and amikacin antibiotics

Journal of Antimicrobial Chemotherapy, 2019
Objectives Persister cells following antibiotic exposure may cause failure of antibiotic treatment. The synergistic effects of antibiotic combinations with respect to eliminating persister cells were investigated based on their characteristics ...
Eun Seon Chung, K. Ko
semanticscholar   +1 more source

Nebulized Amikacin and Fosfomycin for Severe Pseudomonas aeruginosa Pneumonia: An Experimental Study*

Critical Care Medicine, 2019
Objectives: Latest trials failed to confirm merits of nebulized amikacin for critically ill patients with nosocomial pneumonia. We studied various nebulized and IV antibiotic regimens in a porcine model of severe Pseudomonas aeruginosa pneumonia ...
G. Bassi, A. Motos, L. Fernández-Barat, E. Xiol, C. Chiurazzi, T. Senussi, María Adela Saco, C. Fuster, M. Carbonara, J. Bobi, R. Amaro, F. Rosa, T. Comaru, Hua Yang, O. Ranzani, J. Martí, M. Rinaudo, Oscar Comino Trinidad, M. Rigol, J. Bringué, J. Ramírez, D. Nicolau, P. Pelosi, M. Antonelli, F. Blasi, F. Blasi, A. Artigas, A. Montgomery, A. Torres   +28 more
semanticscholar   +1 more source

In vitro activities of carbapenems in combination with amikacin, colistin, or fosfomycin against carbapenem-resistant Acinetobacter baumannii clinical isolates.

Diagnostic microbiology and infectious disease, 2018
Carbapenem-resistant Acinetobacter baumannii clinical isolates (n=23) were investigated for carbapenem resistance mechanisms and in vitro activities of carbapenems in combination with amikacin, colistin, or fosfomycin.
Uthaibhorn Singkham-in, Tanittha Chatsuwan   +1 more
semanticscholar   +1 more source