Results 111 to 120 of about 31,652 (216)

An Engineered Extracellular Vesicle With Enhanced Tumor and Lymph Nodes Targeting as siRNA Delivery System for Robust Tumor Immunotherapy

open access: yesMedComm, Volume 7, Issue 3, March 2026.
Simple incubation with DP7‐C enables the generation of extracellular vesicles (DP‐EVs) with enhanced both tumor and lymph nodes targeting properties. DP‐EVs/siPD‐L1 can effectively inhibit tumor growth and greatly prolong the survival of tumor bearing mice through immune response activation and tumor microenvironment reprogramming.
Yusi Wang   +8 more
wiley   +1 more source

Sodium selectivity of semicircular canal duct epithelial cells

open access: yesBMC Research Notes, 2011
Background Sodium absorption by semicircular canal duct (SCCD) epithelial cells is thought to contribute to the homeostasis of the volume of vestibular endolymph.
Harbidge Donald G   +4 more
doaj   +1 more source

Non‐Invasive, High‐Resolution (1H2O) Metabolic Activity Diffusion Imaging [MADI] of Rat Glioma

open access: yesNMR in Biomedicine, Volume 39, Issue 3, March 2026.
We employed Metabolic Activity Diffusion Imaging [MADI] and 18FDG‐PET in rats with syngeneic RG2 glioblastoma brain tumors. MADI quantifies kio (the cellular H2O efflux rate constant), cell volume (V), and cell density (ρ), without the use of contrast agents. The kioV product quantifies the rate of water efflux per cell.
Joshua W. Schlegel   +9 more
wiley   +1 more source

Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test

open access: yesPain Research and Management, 2015
BACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes.
Handong Ouyang   +5 more
doaj   +1 more source

Amiloride Improves Endothelial Function and Reduces Vascular Stiffness in Female Mice Fed a Western Diet

open access: yesFrontiers in Physiology, 2017
Obese premenopausal women lose their sex related cardiovascular disease protection and develop greater arterial stiffening than age matched men. In female mice, we have shown that consumption of a Western diet (WD), high in fat and refined sugars, is ...
Luis A. Martinez-Lemus   +23 more
doaj   +1 more source

Amiloride and calciuria [PDF]

open access: yesNephrology Dialysis Transplantation, 2021
Friedrich C, Luft, Johan, Sällström
openaire   +2 more sources

Nanoplastics Impair GnRH Neuron Migration and Neuroendocrine Function: Emerging Players in the Pathogenesis of Reproductive Disorders

open access: yesSmall, Volume 22, Issue 15, 12 March 2026.
Little is known about the effects of polystyrene nanoplastics (PS‐NPs) on gonadotropin releasing hormone (GnRH) neurons, which control puberty onset and fertility. By applying tailored in vitro GnRH neuron models, this article shows how PS‐NPs are internalized and impact hormone secretion and cell migration, through gene expression changes. Ultimately,
Federica Amoruso   +14 more
wiley   +1 more source

Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice

open access: yesBMC Endocrine Disorders, 2005
Background Amiloride derivatives, commonly used for their diuretic and antihypertensive properties, can also cause a sustained but reversible decrease of intracellular pH (pHi).
Head W Steven   +2 more
doaj   +1 more source

Integrin-mediated membrane blebbing is dependent on the NHE1 and NCX1 activities. [PDF]

open access: yes, 2011
Integrin-mediated signal transduction and membrane blebbing have been well studied to modulate cell adhesion, spreading and migration^1-6^. However, the relationship between membrane blebbing and integrin signaling has not been explored.
Chi-Hung Lin   +8 more
core   +1 more source

FAST‐CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid‐Silica Hybrid Nanoparticles for Therapeutic Genome Editing

open access: yesSmall, Volume 22, Issue 15, 12 March 2026.
FAST‐CRISPR nanoparticles combine fusogenic lipids and tailored porous silica for rapid and direct cytosolic delivery of CRISPR/Cas9 ribonucleoproteins, bypassing endocytosis. This approach achieves highly efficient genome editing, selectively induces cancer cell apoptosis through multiplex DNA targeting, and effectively suppresses tumor growth in vivo,
Minjong Kim   +14 more
wiley   +1 more source

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