Results 111 to 120 of about 31,652 (216)
Simple incubation with DP7‐C enables the generation of extracellular vesicles (DP‐EVs) with enhanced both tumor and lymph nodes targeting properties. DP‐EVs/siPD‐L1 can effectively inhibit tumor growth and greatly prolong the survival of tumor bearing mice through immune response activation and tumor microenvironment reprogramming.
Yusi Wang +8 more
wiley +1 more source
Sodium selectivity of semicircular canal duct epithelial cells
Background Sodium absorption by semicircular canal duct (SCCD) epithelial cells is thought to contribute to the homeostasis of the volume of vestibular endolymph.
Harbidge Donald G +4 more
doaj +1 more source
Non‐Invasive, High‐Resolution (1H2O) Metabolic Activity Diffusion Imaging [MADI] of Rat Glioma
We employed Metabolic Activity Diffusion Imaging [MADI] and 18FDG‐PET in rats with syngeneic RG2 glioblastoma brain tumors. MADI quantifies kio (the cellular H2O efflux rate constant), cell volume (V), and cell density (ρ), without the use of contrast agents. The kioV product quantifies the rate of water efflux per cell.
Joshua W. Schlegel +9 more
wiley +1 more source
BACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes.
Handong Ouyang +5 more
doaj +1 more source
Obese premenopausal women lose their sex related cardiovascular disease protection and develop greater arterial stiffening than age matched men. In female mice, we have shown that consumption of a Western diet (WD), high in fat and refined sugars, is ...
Luis A. Martinez-Lemus +23 more
doaj +1 more source
Friedrich C, Luft, Johan, Sällström
openaire +2 more sources
Little is known about the effects of polystyrene nanoplastics (PS‐NPs) on gonadotropin releasing hormone (GnRH) neurons, which control puberty onset and fertility. By applying tailored in vitro GnRH neuron models, this article shows how PS‐NPs are internalized and impact hormone secretion and cell migration, through gene expression changes. Ultimately,
Federica Amoruso +14 more
wiley +1 more source
Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice
Background Amiloride derivatives, commonly used for their diuretic and antihypertensive properties, can also cause a sustained but reversible decrease of intracellular pH (pHi).
Head W Steven +2 more
doaj +1 more source
Integrin-mediated membrane blebbing is dependent on the NHE1 and NCX1 activities. [PDF]
Integrin-mediated signal transduction and membrane blebbing have been well studied to modulate cell adhesion, spreading and migration^1-6^. However, the relationship between membrane blebbing and integrin signaling has not been explored.
Chi-Hung Lin +8 more
core +1 more source
FAST‐CRISPR nanoparticles combine fusogenic lipids and tailored porous silica for rapid and direct cytosolic delivery of CRISPR/Cas9 ribonucleoproteins, bypassing endocytosis. This approach achieves highly efficient genome editing, selectively induces cancer cell apoptosis through multiplex DNA targeting, and effectively suppresses tumor growth in vivo,
Minjong Kim +14 more
wiley +1 more source

