Results 101 to 110 of about 29,882 (228)

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Acidic Shift of Optimum pH of Bovine Serum Amine Oxidase upon Immobilization onto Nanostructured Ferric Tannates. [PDF]

Int J Mol Sci, 2022
Rilievo G, Cecconello A, Molinari S, Venerando A, Rutigliano L, Govardhan GT, Kariyawasam DH, Arusei RJ, Zennaro L, Di Paolo ML, Agostinelli E, Vianello F, Magro M.   +12 more
europepmc   +1 more source

Ultra‐Tough Hybrid Supramolecular Gelatin Hydrogels

Small, EarlyView.
Tannic acid‐mediated coacervation compacts gelatin into a dense supramolecular network while generating an acidic microenvironment that activates pre‐embedded bis‐oxazoline crosslinkers. The resulting hybrid hydrogel combines covalent stabilization with reversible energy dissipation, producing high strength, extreme extensibility, substantial toughness,
Patrick Shakari, Christos Leliopoulos, Hamidreza Mokhtari, Rohith Pavan Parvathaneni, Afroditi Kontse, Jöns Hilborn, Oommen P. Varghese   +6 more
wiley   +1 more source

The Biological Implication of Semicarbazide-Sensitive Amine Oxidase (SSAO) Upregulation in Rat Systemic Inflammatory Response under Simulated Aerospace Environment. [PDF]

Int J Mol Sci, 2023
Yan L, Sun C, Zhang Y, Zhang P, Chen Y, Deng Y, Er T, Deng Y, Wang Z, Ma H.   +9 more
europepmc   +1 more source

Engineering Protein‐Polymer Hybrid Multilayer Microreactors as Antioxidant and Anti‐Inflammatory Therapeutics: Effect of Single Enzyme Nanogel Localization Within the Multilayer Systems

Small, EarlyView.
Protein‐based multilayer microreactors combine single‐enzyme nanogels (SENs) and layer‐by‐layer (LbL) assembly to control catalase localization. Positioning the enzyme within the core or at different locations of the multilayer architecture reveals how spatial organization influences antioxidant and anti‐inflammatory activity.
Maria A. Motta, Sergio Martin‐Saldaña, Daniel Sánchez‐deAlcázar, Ana Beloqui, Marcelo Calderón, Aitor Larrañaga   +5 more
wiley   +1 more source

Patterning of Artificial Cell Populations Via Laser Induced Forward Transfer for Controlled and Localized Cargo Uptake and Release

Small, EarlyView.
Polypeptide‐based complex coacervate artificial cells were prepared in situ within a viscoelastic matrix and adhered to the biomaterial ink, which was subsequently LIFT‐printed. The artificial cells preserved their structural stability during printing and retained biologically relevant properties, showing controlled cargo uptake and release ...
Yiğitcan Sümbelli, Núria Ginés Rodriguez, Lars J. M. M. Paffen, Arjan Hazegh Nikroo, Riccardo Levato, Jan C. M. van Hest, Jos Malda   +6 more
wiley   +1 more source

A New Player in Jasmonate-Mediated Stomatal Closure: The Arabidopsis thaliana Copper Amine Oxidase β. [PDF]

Cells, 2021
Fraudentali I, Pedalino C, Tavladoraki P, Angelini R, Cona A.   +4 more
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase. [PDF]

Acta Crystallogr F Struct Biol Commun, 2021
Murakawa T, Suzuki M, Arima T, Sugahara M, Tanaka T, Tanaka R, Iwata S, Nango E, Tono K, Hayashi H, Fukui K, Yano T, Tanizawa K, Okajima T.   +13 more
europepmc   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source