Results 161 to 170 of about 29,882 (228)
Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova +2 more
wiley +1 more source
Unique protonation states of aspartate and topaquinone in the active site of copper amine oxidase. [PDF]
Shoji M +5 more
europepmc +1 more source
ABSTRACT Wearable electrochemical sensors offer promising opportunities for wound‐related biochemical assessment by enabling the detection of wound‐relevant biomarkers directly at the skin–wound interface. In this study, we present a textile‐integrated sensor platform for dual‐analyte response of hydrogen peroxide (H2O2) and enzymatically quantified ...
Adnan Maroof Khan +5 more
wiley +1 more source
Structural Insights into 6-Hydroxypseudooxynicotine Amine Oxidase from Pseudomonas geniculata N1, the Key Enzyme Involved in Nicotine Degradation. [PDF]
Liu G +5 more
europepmc +1 more source
One Hundred Years of Sulfido Ligand in the Molybdenum Cofactor: New Perspectives
The terminal sulfido ligand in mononuclear molybdoenzymes has been appreciated for almost 125 years, with the characterization of Schardinger's enzyme in cow's milk, now known to be xanthine oxidase, that was isolated in 1902 in Vienna, Austria. The ligand is found in molybdoenzymes identified across all kingdoms of life.
Silke Leimkühler +2 more
wiley +1 more source
Searching for Novel COVID19 Treatments: Towards Covalent TMPRSS2 Inhibitors
We designed, synthesised, and evaluated new guanidine derivatives as potential covalent inhibitors of TMPRSS2, a key protease for SARS‐CoV‐2 entry. Computational studies showed that some compounds have improved binding over nafamostat. However, experimentally none effectively blocked viral entry in cell assays, indicating further optimisation is needed.
Marco Minneci +6 more
wiley +1 more source
Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions. [PDF]
Thézénas ML +23 more
europepmc +1 more source
The amine oxidases of mammalian plasma
H, BLASCHKO +3 more
openaire +3 more sources

