Results 91 to 100 of about 16,079 (234)

Metal‐Mediated Protein Engineering within Live Cells

Chemistry – An Asian Journal, Volume 20, Issue 6, March 17, 2025.
This review discusses how metal ions can mediate protein modification within live cells. With its easy handling, rapid solubility, and ease of internalization within the cells, metal ions can be an excellent stimulus for many organic reactions needed within an intracellular medium, which can modify proteins and lead to applications in chemistry ...
Pritam Ghosh
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

A Biocatalytic Cascade for the Valorization of Sugars

ChemCatChem, EarlyView.
We report a one‐pot, three‐step biocatalytic cascade to synthesize trihydroxy‐piperidine and ‐azepane iminosugars directly from monosaccharides, employing transaminase (ATA) and galactose oxidase (GOase) enzymes. Abstract Biocatalytic cascades offer products of multistep synthesis without the use of protecting groups or isolation of intermediates. This
Kathryn Yeow, Aoife Martin, Jimmy Muldoon, Marianne Bore Haarr, Elaine O'Reilly   +4 more
wiley   +1 more source

SAGE-Amine: Generative Amine Design with Multi-Property Optimization for Efficient CO2 Capture [PDF]

Efficient CO2 capture is vital for mitigating climate change, with amine-based solvents being widely used due to their strong reactivity with CO2. However, optimizing key properties such as basicity, viscosity, and absorption capacity remains challenging, as traditional methods rely on labor-intensive experimentation and predefined chemical databases ...
arxiv   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

Chemistry – A European Journal, EarlyView.
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley   +1 more source

Late‐Stage Amination of Peptides on the Solid Phase

Chemistry – A European Journal, EarlyView.
The introduction of amines into peptides via an on‐resin iodination‐substitution reaction sequence provides access to a wide variety of modifications, including amine‐based metal ligands. Primary, secondary, and aromatic amines, as well as heteroaromatic N‐nucleophiles, have been successfully incorporated into the reaction sequence.
Julian Brinkhofer, Marius Werner, Agon Kokollari, Shih‐Yu Pan, Christian Klein, Truc Lam Pham, Franziska Thomas   +6 more
wiley   +1 more source

Effect of ELF e.m. fields on metalloprotein redox-active sites [PDF]

arXiv, 2008
The peculiarity of the distribution and geometry of metallic ions in enzymes pushed us to set the hypothesis that metallic ions in active-site act like tiny antennas able to pick up very feeble e.m. signals. Enzymatic activity of Cu2+, Zn2+ Superoxide Dismutase (SOD1) and Fe2+ Xanthine Oxidase (XO) has been studied, following in vitro generation and ...
arxiv  

Charge‐Assisted Hydrogen‐Bonded Organic Frameworks: From Crystal Engineering to Multifunctional Materials

Chemistry–Methods, EarlyView.
This review briefly highlights the construction of charge‐assisted hydrogen‐bonded organic frameworks using a variety of organic acids and organic bases, which feature different hydrogen‐bonding motifs, along with their applications, including negative linear compressibility, proton conduction, atmospheric water harvesting, gas adsorption and ...
Xian‐Xian Xiao, Kai Zheng, Hao‐Ran Yu, Fang‐Di Dong, Ding‐Yi Hu, Rui‐Biao Lin   +5 more
wiley   +1 more source

Investigation of the coordination chemistry, biomolecular interactions and cytotoxicity of heterocyclic carboxamide manganese(II) complexes

European Journal of Inorganic Chemistry, Accepted Article.
Reactions of ligands 5‐methyl‐N‐(quinolin‐8‐yl)pyrazine‐2‐carboxamide (L1), N‐( N‐(pyridin‐2‐ylmethyl)pyrazine‐2‐carboxamide (L2), N‐(quinolin‐8‐yl)picolinamide (L3), N‐(quinolin‐8‐yl)quinoline‐2‐carboxamide (L4) with the MnCl2.4H2O salt afforded the respective manganese complexes [Mn(L1)(CH3OH)2Cl] (Mn1), [Mn(L2)2] (Mn2) [Mn(L3)2] (Mn3) and [Mn2(L4)2 ...
Nokwanda Tsaulwayo, Koena L. Moabelo, Mervin Meyer, Stephen O. Ojwach   +3 more
wiley   +1 more source

METTL14 contributes to the progression of nasopharyngeal carcinoma through regulating the stability of AOC1 mRNA

Hereditas
Background Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor of the nasopharyngeal mucosa with a high incidence rate all over the world. Methyltransferase-like 14 (METTL14) is a major RNA N6-adenosine methyltransferase implicated in tumor ...
Changan Hu, Shengguan Song, Shanglong Zhao, Zhen Xue, Xiwen Zhu   +4 more
doaj   +1 more source