Results 71 to 80 of about 2,838,820 (225)

The Biological Basis of the Merlin CP‐GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma

International Journal of Dermatology, EarlyView.
Merlin CP‐GEP integrates mechanistic insights into a clinically actionable assay to predict SLN metastasis risk and inform personalized management of cutaneous melanoma. ABSTRACT The recent inclusion of the Merlin clinicopathologic–gene expression profile (CP‐GEP) assay in the National Comprehensive Cancer Network (NCCN) Melanoma Guidelines represents ...
Frank Z. Jing, Alexander Meves
wiley   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Pan-cancer analysis reveals AOC3 as a potential therapeutic biomarker for colorectal cancer

Discover Oncology
Amine oxidase copper containing 3 (AOC3) had been reported to play an important regulatory role in the biological functional pathways, immune microenvironment and cellular function.
Guanlong Wang, Lidan Zhu, Ling Lu, Guangyang Wu, Bangjie Wang, Changjun Yu   +5 more
doaj   +1 more source

Nanoparticles in Periodontology and Implant Dentistry: From Mechanisms to Clinical Applications

Journal of Periodontal Research, EarlyView.
Nanotechnology holds significant promise in improving dental care, yet there is a need for more reliable clinical studies to validate its effectiveness and safety. ABSTRACT Recent advances in nanotechnology are reshaping the landscape of periodontology and implant dentistry, particularly through the application of nanoparticles (NPs).
Chun Xu, Yuan Chen, Mario Romandini, Håvard Jostein Haugen, Sašo Ivanovski   +4 more
wiley   +1 more source

Síntese, caracterização e estudo da reatividade de complexos mononucleares de cobre(II) como sistemas modelos para hidrolases/nucleases e catecolases [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2011Ligantes triaminas cíclicas, tais como o 1,4-diazepan-6-amina (daza), conseguem ...
Westrup, Kátia Cristina Molgero
core  

Engineered surface strategies to manage dental implant‐related infections

Periodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza, Bruna E. Nagay, Rodrigo Martins, Martinna Bertolini, Jamil A. Shibli, Conrado Aparicio, Magda Feres, Valentim A. R. Barão   +7 more
wiley   +1 more source

Vascular-adhesion protein 1 in giant cell arteritis and polymyalgia rheumatica

Frontiers in Medicine
Vascular adhesion protein-1 (VAP-1) is a type 2 transmembrane sialoglycoprotein with oxidative deamination functionality, encoded by the amine oxidase copper-containing 3 (AOC3) gene.
Simon M. Petzinna, Claus-Jürgen Bauer, Valentin S. Schäfer   +2 more
doaj   +1 more source

Downregulation of amine oxidase copper containing 1 inhibits tumor progression by suppressing IL-6/JAK/STAT3 pathway activation in hepatocellular carcinoma. [PDF]

Oncol Lett, 2021
Ding Q, Lin D, Zhou Y, Li F, Lai J, Duan J, Chen J, Jiang C.   +7 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Aokap9 gene knockout contributes to kojic acid synthesis in Aspergillus oryzae

Microbial Cell Factories
Background Kojic acid, a significant secondary metabolite primarily synthesized by Aspergillus oryzae, has extensive applications across various industries. It is imperative to identify effective gene targets that can enhance kojic acid production and to
Ting Qiu, Huanxin Zhang, Yuzhen Li, Lihua Yao, Zhe Zhang   +4 more
doaj   +1 more source