Results 61 to 70 of about 2,838,820 (225)

Yeast cytochrome c oxidase: a model system to study mitochondrial forms of the haem-copper oxidase superfamily. [PDF]

, 2012
The known subunits of yeast mitochondrial cytochrome c oxidase are reviewed. The structures of all eleven of its subunits are explored by building homology models based on the published structures of the homologous bovine subunits and similarities and ...
Maréchal, A, Orengo, Christine, Amandine Maréchal, Peter R. Rich, Brigitte Meunier, Lee, David, Lee, D, Meunier, Brigitte, Maréchal, Amandine, Orengo, C, Meunier, B, Rich, Peter R., Christine Orengo, David Lee, Rich, PR   +14 more
core   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

AOC1 regulates labor initiation through spermidine-induced autophagy of placental trophoblast cells via EIF5A hypusination

Nature Communications
Parturition depends on precise communication between the mother and fetus. While fetal lung signals are known to help initiate labor, the role of the placenta has remained unclear.
Huaiyan Chen, Peihua Long, Zhe Wang, Ruoheng Du, Chagui Zheng, Zhuo Li, Yihuan Xu, Qiaozhen Peng, Xuesong Sui, Yanyu Sui, Xiang Jiang, Qin Li, Lu Gao   +12 more
doaj   +1 more source

Síntese e caracterização de um novo complexo modelo para sítio ativo de metaloenzimas de cobre [PDF]

, 2006
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.Metais de transição fazem parte do sítio ativo de diversas metaloenzimas que desempenham papéis fundamentais em sistemas vivos.
CAMARGO, Tiago Pacheco de
core  

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Structure and Activity of Aspergillus nidulans Copper Amine Oxidase

, 2011
Aspergillus nidulans amine oxidase (ANAO) has the unusual ability among the family of copper and trihydroxyphenylalanine quinone-containing amine oxidases of being able to oxidize the amine side chains of lysine residues in large peptides and proteins ...
Collyer, Charles A, Weiss, Anthony S, McGrath, Aaron P, Arjen Sein, Suzanne M. Mithieux, Mithieux, Suzanne M, Heinz, Andrea, Janny G. Bakhuis, Andrea Heinz, Anthony S. Weiss, van den Berg, Marco, Schmelzer, Christian, Christian Schmelzer, Bakhuis, Janny G, J. Mitchell Guss, Charles A. Collyer, Aaron P. McGrath, Sein, Arjen, Marco van den Berg, Guss, J Mitchell   +19 more
core   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source

Thermal inactivation and conformational lock studies on glucose oxidase [PDF]

In this study, the dissociative thermal inactivation and conformational lock theories are applied for the homodimeric enzyme glucose oxidase (GOD) in order to analyze its structure.
امانی, مجتبی, موسوی موحدی, علی اکبر, دهقان, غلامحسین, ستاری, زهرا, پور فیض, حسین   +4 more
core   +1 more source