Results 171 to 180 of about 7,123 (216)

Copper-Containing Amine Oxidases

1989
Amine oxidases catalyze the reaction $$ R - C{H_2}NH_3^{+} \quad + \quad {O_2}\quad + \quad {H_2}O \to R - CHO\quad + \quad NH_4^{+} \quad + \quad {H_2}{O_2} $$ where R can be either aromatic or aliphatic. The copper-containing amine oxidases (Cu-AOs) oxidize only primary amines at variance with FAD-containing amine oxidases (eg.
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Structure and Reactivity of Copper-Containing Amine Oxidases

1993
In recent years, considerable progress has been made toward understanding the active site structures and mechanisms of copper-containing amine oxidases. Copper-containing amine oxidases are one of the most widely distributed classes of “Type-2” copper enzyme.
David M. Dooley, Doreen E. Brown, Alexander W. Clague, Jyllian N. Kemsley, Cynthia D. McCahon, Michele A. McGuirl, Petra N. Turowski, W. S. McIntire, Jaqui A. Farrar, Andrew J. Thomson   +9 more
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Inhibition of six copper-containing amine oxidases by the antidepressant drug tranylcypromine

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
Potential inhibitory effects of the clinically utilized monoamine oxidase inhibitor tranylcypromine (TCP) on mammalian, plant, bacterial, and fungal copper-containing amine oxidases have been examined. The following enzymes have been investigated: human kidney diamine oxidase (HKAO), bovine plasma amine oxidase (BPAO), equine plasma amine oxidase (EPAO)
Eric M, Shepard, Heather, Heggem, Gregory A, Juda, David M, Dooley   +3 more
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Characterization of the copper-containing amine oxidase from Trifolium pratense seedlings

Nuclear Science and Techniques, 2016
We studied the kinetic characterizations of the Trifolium pratense seedlings copper-containing amine oxidase (TPAO) by using various amine-containing substrates. The catalyzing rate for all of amine-containing substrates can be ordered as diamines > polyamines > aromatic monoamines, and it shows an apparent trend in each category of substrates such as ...
Yong-Ming Zhang, Guo-Long Li, Rui-Bo Zhong, Yu-Xing Ma, Pei Gong, Feng Zhang   +5 more
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Hydroxyl radical production in the reactions of copper-containing amine oxidases with substrates

Biochimica et Biophysica Acta (BBA) - General Subjects, 1993
Solutions of porcine kidney diamine oxidase, PKDAO, and bovine plasma amine oxidase, BPAO, were saturated with the spin-trapping agent alpha-phenyl-N-t-butylnitrone, PBN, and incubated with cadaverine or benzylamine substrate, respectively, under aerobic conditions.
F N, Castellano, Z, He, F T, Greenaway
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Irreversible inhibition of pig kidney copper‐containing amine oxidase by sodium and lithium ions

European Journal of Biochemistry, 2001
Copper amine oxidase was found to be inhibited in a complex way by small alkali metal ions. Classic enzyme kinetic studies showed that Li+ and Na+ were weak noncompetitive inhibitors, whereas the larger alkali metals K+, Rb+ and Cs+ were not inhibitors.
PADIGLIA, ALESSANDRA, MEDDA, ROSARIA, A. LORRAI, M. PACI, J. Z. PEDERSEN, A. BOFFI, A. BELLELLI, A. FINAZZI AGRO, G. FLORIS   +8 more
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Inhibition of copper-containing amine oxidases by Cu(II) complexes and anions

Journal of Molecular Catalysis, 1984
As part of an effort to elucidate the mechanism of O2 reduction by amine oxidases and the role of copper in the overall reaction, inhibition by Cu(II) complexes and anions has been investigated. Copper(II) complexes of 1,10-phenanthroline and 2,2'-bipyridine strongly inhibited both beef plasma and pig kidney amine oxidase.
David M. Dooley, C.E. Coté, Karl C. Golink   +2 more
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Pulsed EPR studies of the semiquinone state of copper-containing amine oxidases

Journal of the American Chemical Society, 1992
The electron spin echo envelope modulation (ESEEM) technique of pulsed EPR spectroscopy was used to further characterize the radical intermediates observed for porcine kidney diamine oxidase and Arthrobacter P1 methylamine oxidase when the enzymes were reduced with substrates in the presence of cyanide under anaerobic conditions. The data obtained show
John McCracken, Jack Peisach, Cheryl E. Cote, Michele A. McGuirl, David M. Dooley   +4 more
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Characterization of Arabidopsis insertional mutants for copper-containing amine oxidases

2010
In plants, polyamines are catabolised by amine oxidases, which are present in different sub-cellular compartments. The chemical identity of AO-catalyzed reaction products depends on mode of polyamine oxidation, hydrogen peroxide representing a shared compound in all the AO-mediated reactions.
ALESSANDRA TISI, PARASKEVI TAVLADORAKI, RODRIGUES POUSADA, RENATO ALBERTO, RODOLFO FEDERICO, RICCARDO ANGELINI, ALESSANDRA CONA   +5 more
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3-hydrazinopyridazine derivatives as inhibitors of the copper containing amine oxidases.

Il Farmaco; edizione scientifica, 1977
A series of 3-hydrazine derivatives with antihypertensive properties were studied as inhibitors of the copper containing amine oxidases. All the compounds with a free hydrazino group were found to be strong-non-competitive inhibitors. Some of them had an inhibitory activity of the same order as that of hydralazine.
F, Buffoni, G, Ignesti, R, Pirisino
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