Results 191 to 200 of about 22,060 (235)

Alkylamino Derivatives of 4-Aminomethylpyridine as Inhibitors of Copper-Containing Amine Oxidases

Journal of Medicinal Chemistry, 2005
The first substratelike, reversible inhibitors of different copper amine oxidases (CAOs) with IC50 (M) as low as 2.0 x 10(-8) corresponding to derivatives of 4-aminomethylpyridine with alkoxy (1a-d), alkylthio (2a,b), and alkylamino (3a-e, 4a-j) groups in the positions 3 and 5 have been prepared and studied.
BERTINI, VINCENZO, F. BUFFONI, G. IGNESTI, N. PICCI, S. TROMBINO, F. IEMMA, ALFEI, SILVANA, POCCI, MARCO, LUCCHESINI, FRANCESCO, A. DE MUNNO   +9 more
openaire   +4 more sources

Inhibition of six copper-containing amine oxidases by the antidepressant drug tranylcypromine

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
Potential inhibitory effects of the clinically utilized monoamine oxidase inhibitor tranylcypromine (TCP) on mammalian, plant, bacterial, and fungal copper-containing amine oxidases have been examined. The following enzymes have been investigated: human kidney diamine oxidase (HKAO), bovine plasma amine oxidase (BPAO), equine plasma amine oxidase (EPAO)
Eric M, Shepard, Heather, Heggem, Gregory A, Juda, David M, Dooley   +3 more
openaire   +2 more sources

Structure and Reactivity of Copper-Containing Amine Oxidases

1993
In recent years, considerable progress has been made toward understanding the active site structures and mechanisms of copper-containing amine oxidases. Copper-containing amine oxidases are one of the most widely distributed classes of “Type-2” copper enzyme.
David M. Dooley, Doreen E. Brown, Alexander W. Clague, Jyllian N. Kemsley, Cynthia D. McCahon, Michele A. McGuirl, Petra N. Turowski, W. S. McIntire, Jaqui A. Farrar, Andrew J. Thomson   +9 more
openaire   +1 more source

Hydroxyl radical production in the reactions of copper-containing amine oxidases with substrates

Biochimica et Biophysica Acta (BBA) - General Subjects, 1993
Solutions of porcine kidney diamine oxidase, PKDAO, and bovine plasma amine oxidase, BPAO, were saturated with the spin-trapping agent alpha-phenyl-N-t-butylnitrone, PBN, and incubated with cadaverine or benzylamine substrate, respectively, under aerobic conditions.
F N, Castellano, Z, He, F T, Greenaway
openaire   +2 more sources

Copper-Containing Amine Oxidases

1989
Amine oxidases catalyze the reaction $$ R - C{H_2}NH_3^{+} \quad + \quad {O_2}\quad + \quad {H_2}O \to R - CHO\quad + \quad NH_4^{+} \quad + \quad {H_2}{O_2} $$ where R can be either aromatic or aliphatic. The copper-containing amine oxidases (Cu-AOs) oxidize only primary amines at variance with FAD-containing amine oxidases (eg.
openaire   +1 more source

Irreversible inhibition of pig kidney copper-containing amine oxidase by sodium and lithium ions

FEBS Journal, 2001
Copper amine oxidase was found to be inhibited in a complex way by small alkali metal ions. Classic enzyme kinetic studies showed that Li+ and Na+ were weak noncompetitive inhibitors, whereas the larger alkali metals K+, Rb+ and Cs+ were not inhibitors.
Alessandra Padiglia, Rosaria Medda, Anita Lorrai   +2 more
exaly   +5 more sources

Interaction of Pig Kidney and Lentil Seedling Copper-Containing Amine Oxidases with Guanidinium Compounds

Journal of Enzyme Inhibition, 1999
The effect of guanidinium compounds on the catalytic mechanism of pig kidney and lentil seedling amine oxidases has been investigated by polarographic techniques and spectroscopy. Guanidine does not inhibit the lentil enzyme and is a weak inhibitor for pig kidney amine oxidase (K(i) =1 mM), whereas aminoguanidine is an irreversible inhibitor of both ...
PADIGLIA, ALESSANDRA, MEDDA, ROSARIA, Lorrai A, Murgia B, Pedersen JZ, Agro AF, Floris G.   +6 more
openaire   +5 more sources

Characterization of the copper-containing amine oxidase from Trifolium pratense seedlings

Nuclear Science and Techniques, 2016
We studied the kinetic characterizations of the Trifolium pratense seedlings copper-containing amine oxidase (TPAO) by using various amine-containing substrates. The catalyzing rate for all of amine-containing substrates can be ordered as diamines > polyamines > aromatic monoamines, and it shows an apparent trend in each category of substrates such as ...
Yong-Ming Zhang, Guo-Long Li, Rui-Bo Zhong, Yu-Xing Ma, Pei Gong, Feng Zhang   +5 more
openaire   +1 more source

Inhibition of copper-containing amine oxidases by Cu(II) complexes and anions

Journal of Molecular Catalysis, 1984
As part of an effort to elucidate the mechanism of O2 reduction by amine oxidases and the role of copper in the overall reaction, inhibition by Cu(II) complexes and anions has been investigated. Copper(II) complexes of 1,10-phenanthroline and 2,2'-bipyridine strongly inhibited both beef plasma and pig kidney amine oxidase.
David M. Dooley, C.E. Coté, Karl C. Golink   +2 more
openaire   +1 more source

Pulsed EPR studies of the semiquinone state of copper-containing amine oxidases

Journal of the American Chemical Society, 1992
The electron spin echo envelope modulation (ESEEM) technique of pulsed EPR spectroscopy was used to further characterize the radical intermediates observed for porcine kidney diamine oxidase and Arthrobacter P1 methylamine oxidase when the enzymes were reduced with substrates in the presence of cyanide under anaerobic conditions. The data obtained show
John McCracken, Jack Peisach, Cheryl E. Cote, Michele A. McGuirl, David M. Dooley   +4 more
openaire   +1 more source