Results 71 to 80 of about 21,994 (249)

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. [PDF]

, 2019
Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the clb genomic island that has a widespread distribution in pathogenic and commensal human enterobacteria.
A Collins, A Cougnoux, AO Brachmann, BR Stern, Bradley S. Moore, CA Brotherton, CA Brotherton, CM Woo, D Payros, E Buc, EP Balskus, EP Rogakou, G Cuevas-Ramos, G Sharon, HB Bode, I Cho, J Chen, JA Stubbe, JC Arthur, Jennifer Y. H. Lai, Jie Li, JK Nicholson, JP Nougayrède, KJ Humphreys, KK Khanna, KS Chaturvedi, L Zha, L Zha, LB Schultz, LC Colis, LF Povirk, M Olier, M Pitie, MI Vizcaino, MI Vizcaino, MR Wilson, MS Donia, MS Donia, MS Melvin, N Bossuet-Greif, N Bossuet-Greif, NS Guntaka, P Engel, P Tripathi, Pei-Yuan Qian, RM Bleich, RM Burger, S Borah, S Tomkovich, Shaun M. K. McKinnie, T Faïs, T Pérez-Berezo, T Secher, TC Holmes, V Bondarev, Wei-Peng Zhang, Wenjun Zhang, Wenlong Cai, X Bian, X Bian, Y Pommier, YA Chan, Z-R Li, Z-R Li, Zhong-Rui Li   +64 more
core   +1 more source

Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis

Arthritis Research & Therapy, 2017
Background Lysyl oxidase like-2 (LOXL2) is a copper-dependent amine oxidase. Our previous studies showed that LOXL2 is elevated during mouse fracture healing.
Weam Alshenibr, Mustafa M. Tashkandi, Saqer F. Alsaqer, Yazeed Alkheriji, Amelia Wise, Sadanand Fulzele, Pushkar Mehra, Mary B. Goldring, Louis C. Gerstenfeld, Manish V. Bais   +9 more
doaj   +1 more source

Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1

Mediators of Inflammation, 2020
Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation.
Ryo Kubota, Michael J. Reid, Kuo Lee Lieu, Mark Orme, Christine Diamond, Niklas Tulberg, Susan H. Henry   +6 more
doaj   +1 more source

Export of functional Streptomyces coelicolor alditol oxidase to the periplasm or cell surface of Escherichia coli and its application in whole-cell biocatalysis [PDF]

, 2009
Streptomyces coelicolor A3(2) alditol oxidase (AldO) is a soluble monomeric flavoprotein in which the flavin cofactor is covalently linked to the polypeptide chain.
AJ Driessen, BJ Feilmeier, C Filip, CA Kumamoto, CF Schierle, CM Cho, CR Raetz, D Huber, D Schmid, D Tullman-Ercek, DP Heuts, E Brickman, E Frirdich, E Vrontou, EW van Hellemond, F Forneris, FJ Mergulhao, HC Jung, J Jose, J Luirink, J Zhou, JD Thomas, JS Lee, K Nakai, L Li, M Marrichi, M Shimazu, M Shimazu, MA Turner, MJ Casadaban, MJ Casadaban, ML Wu, MW Fraaije, NG Leferink, P Samuelson, PA Lee, PH Wu, R Federico, S Cristobal, SK Yim, SM Kang, SP Graether, SY Lee, T Baba, T Bruser   +44 more
core   +10 more sources

Ligand architecture and secondary‐sphere effects in a well‐defined cobalt(IV)–oxo complex

Bulletin of the Korean Chemical Society, EarlyView.
A well‐defined cobalt(IV)–oxo complex supported by a neutral tetraazamacrocyclic ligand is generated and fully characterized. The cobalt(IV)–oxo species exhibits electrophilic oxygen‐atom and hydrogen‐atom transfer reactivity, strongly modulated by protonation and secondary coordination sphere effects, providing new insight into structure–reactivity ...
Ying Xing, Mi Sook Seo, Yong‐Min Lee, Wonwoo Nam   +3 more
wiley   +1 more source

Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model

Frontiers in Pharmacology
IntroductionMonoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol ...
Ádám István Horváth, Ádám István Horváth, Kata Bölcskei, Nikolett Szentes, Nikolett Szentes, Nikolett Szentes, Éva Borbély, Éva Borbély, Valéria Tékus, Valéria Tékus, Valéria Tékus, Bálint Botz, Kitti Rusznák, Kitti Rusznák, Anett Futácsi, Anett Futácsi, Boldizsár Czéh, Boldizsár Czéh, Péter Mátyus, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes   +23 more
doaj   +1 more source

Leaf apoplastic proteome composition in UV-B treated Arabidopsis thaliana mutants impaired in extracellular glutathione degradation [PDF]

, 2016
In plants, environmental perturbations often result in oxidative reactions in the apoplastic space, which are counteracted for by enzymatic and non-enzymatic antioxidative systems, including ascorbate and glutathione. The occurrence of the latter and its
Arrigoni, Giorgio, Masi, Antonio, Trentin, ANNA RITA   +2 more
core   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Catalytically active bovine serum amine oxidase bound to fluorescent and magnetically drivable nanoparticles

International Journal of Nanomedicine, 2012
Giulietta Sinigaglia1, Massimiliano Magro1, Giovanni Miotto1, Sara Cardillo1, Enzo Agostinelli2,3, Radek Zboril4, Eris Bidollari2,3, Fabio Vianello11Department of Biological Chemistry, University of Padua, Padua, Italy; 2Istituto Pasteur-Fondazione Cenci
Bidollari E, Zboril R, Agostinelli E, Cardillo S, Vianello F, Miotto G, Magro M, Sinigaglia G   +7 more
doaj  

Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arhtritis Models of the Mouse [PDF]

, 2017
L
Bogdán, Dóra, Borbély, Éva, Botz, Bálint, Csepregi, Janka Zsófia, Helyes, Zsuzsanna, Horváth, Ádám, Juhász, Tamás, Keeble, Julie, Kemény, Ágnes, Menghis, Awt, Mátyus, Péter, Mócsai, Attila, Pintér, Erika, Tékus, Valéria, Zákány, Róza   +14 more
core   +5 more sources