Results 121 to 130 of about 8,614,620 (399)

Branched chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

Nature Chemical Biology, 2015
Adipose tissue plays important roles in regulating carbohydrate and lipid homeostasis, though less is known about the regulation of amino acid metabolism in adipocytes.
Courtney R. Green, M. Wallace, Ajit S. Divakaruni, S. Phillips, A. Murphy, T. Ciaraldi, Christian M. Metallo   +6 more
semanticscholar   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Amino acid-responsive Crohn's disease: a case study

Clinical and Experimental Gastroenterology, 2010
Alvin Stein1, Marty Hinz2, Thomas Uncini31Stein Orthopedic Associates, Plantation, FL, USA; 2Clinical Research, NeuroResearch Clinics Inc., Cape Coral, FL, USA; 3Laboratory, Fairview Regional Medical Center-Mesabi, Hibbing, MN, USAPurpose: This paper ...
Alvin Stein, Marty Hinz, Thomas Uncini
doaj  

Chemical factors in the germination of spore-bearing aerobes. The effects of amino-acids on the germination of Bacillus anthracis, with some observations on the relation of optical form to biological activity [PDF]

, 1949
George Hills
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Hydroxyapatite Fabrication for Enhancing Biohydrogen Production from Glucose Dark Fermentation

ACS Omega, 2022
Haoe Mo, Na Wang, Zhongmin Ma, Jishi Zhang, Jinlong Zhang, Lu Wang, Weifang Dong, Lihua Zang   +7 more
doaj   +1 more source

Experiments on the Interaction of Hydroxy- and Amino-Acids with Nitrophenylhydrazine with Special Reference to the Formation of Glyoxal Derivatives [PDF]

, 1916
H.D. Dakin
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

An economic demand-based framework for prioritization strategies in response to transient amino acid limitations

Nature Communications
Cells contain disparate amounts of distinct amino acids, each of which has different metabolic and chemical origins, but the supply cost vs demand requirements of each is unclear.
Ritu Gupta, Swagata Adhikary, Nidhi Dalpatraj, Sunil Laxman   +3 more
doaj   +1 more source

C₂-Symmetric Amino Acid Amide-Derived Organocatalysts

Reactions
N-alkylated C2-symmetric amino acid amide derivatives were shown to catalyse the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 44%.
Zahraa S. Al-Taie, Simon J. Coles, Aileen Congreve, Dylan Ford, Lucy Green, Peter N. Horton, Leigh F. Jones, Pippa Kett, Rolf Kraehenbuehl, Patrick J. Murphy, Graham J. Tizzard, Niles B. Willmore, Oliver T. Wright   +12 more
doaj   +1 more source