Results 131 to 140 of about 2,226,397 (316)

Aptamer-Functionalized Interface Nanopores Enable Amino Acid-Specific Peptide Detection

Single-molecule proteomics based on nanopore technology has made significant advances in recent years. However, to achieve nanopore sensing with single amino acid resolution, several bottlenecks must be tackled: controlling nanopore sizes with nanoscale ...
Schlotter, Tilman, Kloter, Tom, Zhang, Xinyu, Zhan, Lijian, Vörös, Janos, Yang, Kyungae, Ragavan, Sujeni, Hu, Haiying, Nakatsuka, Nako, Duru, Jens, Zambelli, Tomaso, Hengsteler, Julian   +11 more
core   +1 more source

Engineering Dehydrated Amino Acid Residues in the Antimicrobial Peptide Nisin [PDF]

, 1992
The small antimicrobial peptide nisin, produced by Lactococcus lactis, contains the uncommon amino acid residues dehydroalanine and dehydrobutyrine and five thio ether bridges.
Rollema, Harry S., Boot, Hein J., Kuipers, Oscar P.,, Boot, Hein J.,, Kuipers, Oscar P., Yap, Wyanda M.G.J., Rollema, Harry S.,, Siezen, Roland J., Vos, Willem M. de, Vos, Willem M. de,, Siezen, Roland J.,, Yap, Wyanda M.G.J.,   +11 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Amino Acid Uptake and Yeast Gene Transcription during Industrial Brewery Fermentation

, 2009
Amino acid utilization by yeast during brewer's wort fermentation influences both the fermentation performance and flavor profile of the finished product.
Brian R. Gibson, Wendy G. Box, Gibson, Brian R., Smart, Katherine A., Neil S. Graham, Box, Wendy G., Katherine A. Smart, Boulton, Chris A., Chris A. Boulton, Graham, Neil S., Linforth, Robert S.T., Robert S. T. Linforth, Stephen J. Lawrence, Lawrence, Stephen J.   +13 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Evidence for two pharmacologically distinct populations of glutamate-activated first order interneurons in a vertebrate spinal cord.

, 1987
p. 357-360.The Atlantic stingray, Dasyatis sabina, is being employed as a simple vertebrate model for studying spinal cord circuitry. Current investigations are aimed at determining the role of excitatory amino acids in the production of spinal reflexes.
Leonard, R.B., Gannon, R.L.
core  

Control of three-carbon amino acid homeostasis by promiscuous importers and exporters in Bacillus subtilis: role of the “sleeping beauty” amino acid exporters

mBio
The Gram-positive model bacterium Bacillus subtilis can acquire amino acids by import, de novo biosynthesis, or degradation of proteins and peptides. The accumulation of several amino acids inhibits the growth of B.
Robert Warneke, Christina Herzberg, Richard Daniel, Björn Hormes, Jörg Stülke   +4 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Computer-aided design of amino acid-based therapeutics: a review

, 2018
Tayebeh Farhadi,1 Seyed MohammadReza Hashemian1,2 1Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Clinical ...
Farhadi T, Hashemian SM
core  

Snake venom L-amino acid oxidases

, 2002
L-amino acid oxidases are widely found in snake venoms and are thought to contribute to the toxicity upon envenomation. The mechanism of these toxic effects and whether they result from the enzymatic activity are still uncertain although many papers ...
Du, XY, Clemetson, KJ
core   +1 more source