Results 151 to 160 of about 5,008,376 (303)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Prognostic Significance of Amino Acid Transporters in Endometrial Cancer. [PDF]

Cancers (Basel)
Zaborowski MP, Ciecierski Ł, Tyburski P, Nadolna M, Szczygieł MB, Sikora J, Szot M, Malewski S, Iwanicki M, Piątek-Bajan K, Lewandowski J, Miedziarek C, Potograbski M, Horst N, Nowak-Markwitz E.   +14 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Inhibitors of the Neutral Amino Acid Transporter SLC6A19 May Treat Diseases or Disorders Associated with Abnormal Amino Acid Metabolism, Epithelial Amino Acid Transport, and/or Amino Acid Levels. [PDF]

ACS Med Chem Lett
Abdel-Magid AF.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The effect of amino acid chelated iron in pregnant and lactating sows

, 1993
Data are presented from literature and from authors' experimental trials about the effects of amino acid chelated iron on productive and reproductive performance of ...
VOLPELLI, Luisa Antonella, C. SACCHI, F. RICCI BITTI, P. PARISINI   +3 more
core  

Beta Cell Proinsulin Response to Amino Acid Availability. [PDF]

Cells
Ruan Y, Gleason NF, Arvan P.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

The Evolutionary Maintenance of Amino Acid Prototrophy in Escherichia coli. [PDF]

Genome Biol Evol
Lindahl O, Berruga-Fernández T, Soekhoe J, Huseby DL, Hughes D.   +4 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source