Results 151 to 160 of about 1,964,821 (266)

Structural basis for pH-responsive amino acid transport via SLC7A4. [PDF]

Nat Commun
Kolokouris D, Bothra A, Kato T, Zeng YC, Lichtinger S, Parker JL, Biggin PC, Newstead S.   +7 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Multi-omics identification of amino acid and redox dysregulation in cystic fibrosis-related diabetes. [PDF]

J Cyst Fibros
Oh SY, Kim SO, Lyles JT, Ajani S, Hunt WR, McCarty NA, Daley T, Stallings VA, Stecenko AA, Tangpricha V, Ziegler TR, Alvarez JA, Chandler JD.   +12 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Breeding for colored quality protein popcorn with improved amino acid composition. [PDF]

Front Plant Sci
Niyorukundo J, Yobi A, Sithole C, Wehrbein C, Angelovici R, Holding DR.   +5 more
europepmc   +1 more source

Amino Acid Analyzer [PDF]

Science, 1973
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

An explainable prognostic prediction panel for sepsis based on serum amino acid profiles. [PDF]

Front Immunol
Liu Y, Zhao L, Sun M, Zhang J, Gu C, Hu N, Gu S, Shi Y.   +7 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Engineering Robust Supramolecular Nanoassemblies from Amino-Acid Functionalized Stiff-Stilbene Amphiphiles. [PDF]

Small Sci
Kwan KS, Chau MH, Wong WK, Kajitani T, Leung FK.   +4 more
europepmc   +1 more source