Results 181 to 190 of about 1,090,848 (316)

Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo: Revealing the sequence plasticity of PB2-627 position

, 2014
Alex W. H. Chin, Olive T. W. Li, Chris Mok, Miko K.W. Ng, Malik Peiris, Leo L. M. Poon   +5 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Variations in candidalysin amino acid sequence influence toxicity and host responses. [PDF]

mBio
Wickramasinghe DN, Lyon CM, Lee S, Hepworth OW, Priest EL, Maufrais C, Ryan AP, Permal E, Sullivan D, McManus BA, Hube B, Butler G, d'Enfert C, Naglik JR, Richardson JP.   +14 more
europepmc   +1 more source

Effect of Genomic and Amino Acid Sequence Mutation on Virulence and Therapeutic Target of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS COV-2). [PDF]

Infect Drug Resist, 2021
Kelta Wabalo E, Dukessa Dubiwak A, Welde Senbetu M, Sime Gizaw T.   +3 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Translated Amino Acid Sequence of an Insertion in the Hepatitis E Virus Strain 47832c Genome, But Not the RNA Sequence, Is Essential for Efficient Cell Culture Replication. [PDF]

Viruses, 2021
Scholz J, Falkenhagen A, Johne R.
europepmc   +1 more source

The amino acid sequences of the carboxyl termini of human and mouse hepatic lipase influence cell surface association [PDF]

, 2003
Robert Brown, Joshua R. Schultz, Kerry W.S. Ko, John S. Hill, Tanya A. Ramsamy, Ann L. White, Daniel L. Sparks, Zemin Yao   +7 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Functional and structural analyses of amino acid sequence variation in PDC β-lactamase reveal different mechanistic pathways toward cefiderocol resistance in <i>Pseudomonas aeruginosa</i>. [PDF]

Antimicrob Agents Chemother
González-Pinto L, Gomis-Font MA, Lence E, Outeda-García M, Blanco-Martín T, Rodríguez-Pallares S, Sánchez-Peña L, Alonso-García I, Vázquez-Ucha JC, Beceiro A, Bou G, González-Bello C, Oliver A, Arca-Suárez J.   +13 more
europepmc   +1 more source

<b>PURIFICATION AND THE PARTIAL AMINO ACID SEQUENCE OF A NOVEL ACTIVATOR OF RYANODINE RECEPTOR (BmK AS-1) FROM MAMMALIAN SKELETAL </b><b>MUSCLE </b>

, 1996
Yan Liu, Ren Huimin, Yonghua Ji, Takahide Ohishi, Tohru Mochizuki, Minoru Hoshino, Noboru Yanaihara   +6 more
openalex   +2 more sources