Results 141 to 150 of about 174 (173)
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Journal of Membrane Biology, 1999
A reevaluation of the specificity of system y+, the classical transporter for cationic amino acids is presented. System y+ has been defined as a transporter for cationic amino acids that binds neutral amino acids with lower affinity in the presence of Na+.
A M, Rojas, R, Devés
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A reevaluation of the specificity of system y+, the classical transporter for cationic amino acids is presented. System y+ has been defined as a transporter for cationic amino acids that binds neutral amino acids with lower affinity in the presence of Na+.
A M, Rojas, R, Devés
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American Journal of Physiology-Endocrinology and Metabolism, 1994
Transport of cationic amino acids in fully differentiated mammalian cells is mediated primarily by system y1+ [cationic amino acid transporter (CAT)-1 gene product]. Antibodies, prepared against synthetic peptide sequences predicted to be extracellular loops of the CAT-1 transporter protein, detected the transporter on the surface of cultured cells. In
M H, Woodard +7 more
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Transport of cationic amino acids in fully differentiated mammalian cells is mediated primarily by system y1+ [cationic amino acid transporter (CAT)-1 gene product]. Antibodies, prepared against synthetic peptide sequences predicted to be extracellular loops of the CAT-1 transporter protein, detected the transporter on the surface of cultured cells. In
M H, Woodard +7 more
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Identification of the Cationic Amino Acid Transporter (System y+) of the Rat Blood‐Brain Barrier
Journal of Neurochemistry, 1993Abstract: Cationic amino acids are transported from blood into brain by a saturable carrier at the blood‐brain barrier (BBB). The transport properties of this carrier were examined in the rat using an in situ brain perfusion technique. Influx into brain via this system was found to be sodium independent and followed Michaelis‐Men‐ten kinetics with ...
J, Stoll, K C, Wadhwani, Q R, Smith
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The Journal of Membrane Biology, 1994
The transport specificity of system y+L of human erythrocytes was investigated and the carrier was found to accept a wide range of amino acids as substrates. Relative rates of entry for various amino acids were estimated from their trans-effects on the unidirectional efflux of L-[14C]-lysine.
S, Angelo, R, Devés
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The transport specificity of system y+L of human erythrocytes was investigated and the carrier was found to accept a wide range of amino acids as substrates. Relative rates of entry for various amino acids were estimated from their trans-effects on the unidirectional efflux of L-[14C]-lysine.
S, Angelo, R, Devés
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Pflügers Archiv, 2000
We test the hypothesis that lysinuric protein intolerance (LPI), a rare autosomal recessive defect of cationic amino acid transport, results from the absence of the recently described y+L amino acid transporter. We compare fluxes of lysine (1 microM) into erythrocytes of normal subjects with those of patients homozygous for the LPI mutation.
BOYD CA +4 more
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We test the hypothesis that lysinuric protein intolerance (LPI), a rare autosomal recessive defect of cationic amino acid transport, results from the absence of the recently described y+L amino acid transporter. We compare fluxes of lysine (1 microM) into erythrocytes of normal subjects with those of patients homozygous for the LPI mutation.
BOYD CA +4 more
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Archives of Biochemistry and Biophysics, 1985
Three major pathways mediate amino acid transport into mammalian cells: the A-system and the ASC-system, which require a sodium gradient across the plasma membrane, and the L-system, which has no requirement for a sodium gradient. We have found that the lymphocytes from patients with B-cell chronic lymphocytic leukemia (CLL) have a marked reduction in ...
G B, Segel, A M, Tometsko, M A, Lichtman
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Three major pathways mediate amino acid transport into mammalian cells: the A-system and the ASC-system, which require a sodium gradient across the plasma membrane, and the L-system, which has no requirement for a sodium gradient. We have found that the lymphocytes from patients with B-cell chronic lymphocytic leukemia (CLL) have a marked reduction in ...
G B, Segel, A M, Tometsko, M A, Lichtman
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Structural insights into the human system y+L amino acid transporter complex
StructureSystem y+L facilitates the sodium-independent transport of cationic and sodium-dependent transport of neutral amino acids via heteromeric amino acid transporters. System y+L consists of either SLC7A6 (y+LAT2) or SLC7A7 (y+LAT1) and 4F2hc (SLC3A2). The y+LAT2-4F2hc complex mediates the exchange of L-lysine (Lys), L-arginine (Arg), L-leucine (Leu), and L-
Lu Dai +9 more
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 1987
The transport of glycine and L-lysine into murine P388 leukemia cells has been examined. Glycine transport appears to be shared by both systems A and ASC in P388 cells. Glycine transport is Na+-dependent and is effectively blocked by alpha-(methylamino)isobutyric acid, threonine and alanine but only a marginal reduction in transport is seen with 100 ...
P, Lazarus, L C, Panasci
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The transport of glycine and L-lysine into murine P388 leukemia cells has been examined. Glycine transport appears to be shared by both systems A and ASC in P388 cells. Glycine transport is Na+-dependent and is effectively blocked by alpha-(methylamino)isobutyric acid, threonine and alanine but only a marginal reduction in transport is seen with 100 ...
P, Lazarus, L C, Panasci
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Journal of Cellular Physiology, 1993
AbstractThe uptake of L‐leucine and L‐lysine into vascular smooth muscle cells cultured from the aortas of rats has been investigated. Both amino acids are taken up by saturable systems that are independent of the presence of a ·Na+ gradient and can be stimulated in trans by neutral bulky amino acids for leucine and cationic amino acids for lysine ...
B C, Low, I K, Ross, M R, Grigor
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AbstractThe uptake of L‐leucine and L‐lysine into vascular smooth muscle cells cultured from the aortas of rats has been investigated. Both amino acids are taken up by saturable systems that are independent of the presence of a ·Na+ gradient and can be stimulated in trans by neutral bulky amino acids for leucine and cationic amino acids for lysine ...
B C, Low, I K, Ross, M R, Grigor
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Biochemistry, 1993
Two-microelectrode voltage clamp was used to measure membrane currents resulting from flux of cationic amino acids in Xenopus oocytes expressing the cloned dual-function ecotropic murine leukemia virus receptor/system y+ transporter. At membrane potentials ranging from +20 mV to -120 mV, arginine influx obeyed Michaelis-Menten kinetics.
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Two-microelectrode voltage clamp was used to measure membrane currents resulting from flux of cationic amino acids in Xenopus oocytes expressing the cloned dual-function ecotropic murine leukemia virus receptor/system y+ transporter. At membrane potentials ranging from +20 mV to -120 mV, arginine influx obeyed Michaelis-Menten kinetics.
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