Results 231 to 240 of about 200,555 (262)
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Expression of a system L neutral amino acid transporter at the blood–brain barrier
NeuroReport, 2000Amino acid transport system L has been proposed to be one of the major nutrient transport systems at the blood-brain barrier. Using immunohistochemical analyses, a system L transporter LAT1 was shown to be expressed in the brain capillary endothelial cells in rats.
H, Matsuo +10 more
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Reconstitution of Neutral Amino Acid Transport System from Ehrlich Ascites Tumor Cells
Membrane Biochemistry, 1978Amino acid transport systems for alanine and leucine were reconstituted into artificial lipid vesicles. Purified plasma membrane vesicles from Ehrlich ascites cells were dissolved in 2% sodium cholate, 1mM dithiothreitol, and 0.5 mM EDTA a mixture that solubilized approximately 50% of the membrane protein.
G, Cecchini, G S, Payne, D L, Oxender
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Placenta, 1998
Placental uptake and transport of three nonmetabolizable amino acids with different reactivities for transport systems were studied in sheep under normal physiologic conditions. Methylaminoisobutyric acid (MeAIB), which has specific affinity for the sodium-dependent A system transporters, demonstrated placental concentrative uptake from the uterine and
Józwik, MC +5 more
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Placental uptake and transport of three nonmetabolizable amino acids with different reactivities for transport systems were studied in sheep under normal physiologic conditions. Methylaminoisobutyric acid (MeAIB), which has specific affinity for the sodium-dependent A system transporters, demonstrated placental concentrative uptake from the uterine and
Józwik, MC +5 more
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Adaptive regulation of neutral amino acid transport system A in rat H4 hepatoma cells
Journal of Cellular Physiology, 1985AbstractSubstrate regulation of System A transport activity in rat H4 hepatoma cells is described. The uptake of several amino acids was tested in the presence of system‐specific inhibitors. System A activity was increased in a RNA‐ and protein synthesis‐dependent manner by amino acid deprivation of the cells (adaptive regulation), whereas transport by
M S, Kilberg +3 more
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System ASC and sodium-independent neutral amino acid transport in muscle of uremic rats
American Journal of Physiology-Renal Physiology, 1986Neutral amino acids are transported by systems A, ASC, and L. In the previous companion study we demonstrated that 2-(methylamino) isobutyrate (MeAIB) is a specific substrate for system A in muscle and that stimulation of system A by physiological concentrations of insulin is preserved in acute uremia (ARF).
B J, Maroni, G, Karapanos, W E, Mitch
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Role of hepatic neutral amino acid transport in systemic metabolic control
2023This thesis examines the restriction of dietary amino acids as a treatment for type 2 diabetes and related disorders. It identifies a promising therapeutic strategy to mimic the cardiometabolic benefits of restricting dietary amino acids while circumventing its disadvantages.
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Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
Pfl�gers Archiv European Journal of Physiology, 2004The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family resemble the classically-described System A and System N transport activities in terms of their functional properties and patterns of regulation. Transport of small, aliphatic amino acids by System A subtypes (SNAT1, SNAT2, and SNAT4) is rheogenic and pH sensitive.
Bryan, Mackenzie, Jeffrey D, Erickson
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Biochemical and Biophysical Research Communications, 1976
Summary The effect of glucagon on neutral amino acid transport systems was studied in freshly-prepared suspensions of isolated hepatocytes by measuring basal and hormone-stimulated α-aminoisobutyric acid (AIB) and cycloleucine uptake. Glucagon stimulated AIB uptake against a concentration gradient.
A, Le Cam, P, Freychet
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Summary The effect of glucagon on neutral amino acid transport systems was studied in freshly-prepared suspensions of isolated hepatocytes by measuring basal and hormone-stimulated α-aminoisobutyric acid (AIB) and cycloleucine uptake. Glucagon stimulated AIB uptake against a concentration gradient.
A, Le Cam, P, Freychet
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Journal of Neurochemistry, 1971
Abstract— The effects of high circulating concentrations of several amino acids on the free amino acids of rat brain were measured, to see whether or not the results followed any consistent pattern. High circulating concentrations of large, neutral amino acids (phenylalanine, valine or isoleucine) caused significantly decreased values only of other ...
J J, Richter, A, Wainer
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Abstract— The effects of high circulating concentrations of several amino acids on the free amino acids of rat brain were measured, to see whether or not the results followed any consistent pattern. High circulating concentrations of large, neutral amino acids (phenylalanine, valine or isoleucine) caused significantly decreased values only of other ...
J J, Richter, A, Wainer
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Brain Research, 1990
The significance of the dense labeling pattern of methylmercury (MeHg) over astrocytes in areas of damaged cortex remains obscure, and the extent to which individual neurons are altered by MeHg accumulation in astrocytes is unknown. As a first step in understanding the relationship between the astrocyte and the mechanisms of MeHg's neurotoxicity ...
M, Aschner +3 more
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The significance of the dense labeling pattern of methylmercury (MeHg) over astrocytes in areas of damaged cortex remains obscure, and the extent to which individual neurons are altered by MeHg accumulation in astrocytes is unknown. As a first step in understanding the relationship between the astrocyte and the mechanisms of MeHg's neurotoxicity ...
M, Aschner +3 more
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