Results 91 to 100 of about 7,755,658 (385)

Effect of weight loss interventions on metabolomic signatures in obese children with insulin resistance

Amino Acids
The obesity epidemic among children has become a major public health issue, and the presence of childhood insulin resistance (IR) has been demonstrated prior to the onset of type 2 diabetes mellitus.
Xiaoguang Liu, Lin Zhu, Jingxin Liu, Zichen Nie, Wenjun Qiu   +4 more
doaj   +1 more source

Impact contribution of prebiotic reactants to Earth [PDF]

It is proposed that the AIB amino acid at the K/T boundary were synthesized during entry of a comet. However, whether they were synthesized or supplied directly from space, the concentration of amino acids in the shallow K/T sea would have been about 10 ...
Aggarwal, Hans R.
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

SNAT2-mediated regulation of estrogen and progesterone in the proliferation of goat mammary epithelial cells

Amino Acids
The development of the goat mammary gland is mainly under the control of ovarian hormones particularly estrogen and progesterone (P4). Amino acids play an essential role in mammary gland development and milk production, and sodium-coupled neutral amino ...
Tingting Jiang, Xiaoyue Ma, Hanling Liu, Qianqian Jia, Jianguo Chen, Yi Ding, Ming Sun, Hongmei Zhu   +7 more
doaj   +1 more source

The Triplet Genetic Code had a Doublet Predecessor

, 2004
Information theoretic analysis of genetic languages indicates that the naturally occurring 20 amino acids and the triplet genetic code arose by duplication of 10 amino acids of class-II and a doublet genetic code having codons NNY and anticodons ...
Patel, Apoorva
core  

Modification of Aminoacyl tRNA Synthetase in Order to Incorporate an Unnatural Amino Acid [PDF]

, 2018
Proteins allow daily processes in the cell to occur. A protein consists of amino acids. There are twenty natural amino acids coded for in the DNA of organisms. The natural amino acids can be modified to form unnatural amino acids (UAAs). UAAs have useful
Burkhart, Grace
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Systematic qualitative proteome-wide analysis of lysine malonylation profiling in Platycodon grandiflorus

Amino Acids
In recent years, it was found that lysine malonylation modification can affect biological metabolism and play an important role in plant life activities. Platycodon grandiflorus, an economic crop and medicinal plant, had no reports on malonylation in the
Qingshan Yang, Shaowei Xu, Weimin Jiang, Fei Meng, Shuting Wang, Zongping Sun, Na Chen, Daiyin Peng, Juan Liu, Shihai Xing   +9 more
doaj   +1 more source

Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder [PDF]

, 2021
Jiang Zhu, Xueying Hua, Ting Yang, Min Guo, Qiu Li, Lu Xiao, Ling Li, Jie Chen, Tingyu Li   +8 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source