Results 71 to 80 of about 2,550,027 (311)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Biocompatible silver nanoparticles prepared with amino acids and a green method

, 2017
The synthesis of nanoparticles is usually carried out by chemical reduction, which is effective but uses many toxic substances, making the process potentially harmful to the environment.
de Matos, Ricardo Almeida [UNIFESP], Courrol, Lilia Coronato [UNIFESP]   +1 more
core   +1 more source

Protolytic properties and biological activity of spinorphin and its butyric acid derivatives in aqueous solution

Amino Acids
The present work describes the protolytic properties and in vitro biological activity of spinorphin (Leu-Val-Val-Tyr-Pro-Trp-Thr) and three spinorphin derivatives containing butyric acid residue: Butyryl-Lys-Lys-Leu-Leu-Val-Tyr-Pro-Trp-Thr, Butyryl-Lys ...
Marek Pająk, Elżbieta Kamysz, Marcin Banach, Wojciech Michał Jankowski, Aleksandra Tarasiuk-Zawadzka, Jakub Fichna, Magdalena Woźniczka   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

L-tyrosine inhibits the formation of amyloid fibers of human lysozyme at physiological pH and temperature

Amino Acids
Amyloid fibers are implicated in numerous diseases, making their study crucial for identifying effective therapeutic compounds. This research highlights the ability of L-tyrosine to inhibit the formation of amyloid fibers in human lysozyme.
Santos López, Arturo Rojo-Domínguez, Roxana López-Simeon, Alejandro Sosa-Peinado, Hugo Nájera   +4 more
doaj   +1 more source

Mild and effective N-phthaloylation of amino acids

, 2004
In the present work various free amino acids, including tryptophan and tyrosine, were effectively N-phthaloylated under reduced pressure and at lower temperature.
Liu, Z, 曾庆乐, Zeng, Q, Li, B, Wang, F   +4 more
core  

Mechanisms of insulin secretion in malnutrition: modulation by amino acids in rodent models

, 2011
Protein restriction at early stages of life reduces beta-cell volume, number of insulin-containing granules, insulin content and release by pancreatic islets in response to glucose and other secretagogues, abnormalities similar to those seen in type 2 ...
Machado de Oliveira, Camila Aparecida, Latorraca, Marcia Queiroz, Oliveira, Camila Aparecida Machado de [UNIFESP], Carneiro, Everardo Magalhaes, Rostom de Mello, Maria Alice, Rostom de Mello, Maria Alice [UNESP]   +5 more
core   +1 more source

Amino acid racemization dating: Method development using African ostrich (Struthio camelus) eggshell [PDF]

, 2013
Ostrich eggshell (OES) is ubiquitous in archaeological sites in Africa and is a favoured substrate for amino acid racemisation (AAR) geochronology, yielding consistent results and thought to approximate a closed system with respect to protein diagenesis.
Crisp, Molly Katherine
core   +4 more sources

Sex differences in amino acids lost via sweating could lead to differential susceptibilities to disturbances in nitrogen balance and collagen turnover

, 2017
Fluid collected during sweating is enriched with amino acids derived from the skin’s natural moisturising factors and has been termed “faux” sweat. Little is known about sex differences in sweat amino acid composition or whether faux sweat amino acid ...
Stevens, Christopher J, T. K. Roberts, Gottfries, C G, Dunstan, R H, Sparkes, D L, J. Gottfries, R. H. Dunstan, Murphy, G. R., Gottfries, J, M. M. Macdonald, Murphy, G R, Gottfries, J., Dascombe, Ben (R21089), C.-G. Gottfries, Roberts, T K, Sparkes, D. L., Stevens, Christopher J., C. J. Stevens, Dascombe, B. J., Gottfries, C. G., B. J. Dascombe, Dascombe, B J, Macdonald, M. M., Stevens, C. J., Dunstan, R. H., Roberts, T. K., Macdonald, M M, Gottfries, Johan,, D. L. Sparkes, Gottfries, C.-G., G. R. Murphy   +30 more
core   +1 more source

Synthetic receptors for the differentiation of phosphorylated peptides and synthesis and use of tetrahydrofuran amino acids [PDF]

, 2010
In the first part of the work a combination of bis(Zn(II)-cyclen) triazine metal complex binding sites with guanidinium moieties or Zn(II)-NTA complexes leads to artificial receptors for the differentiation of phosphorylated peptides which contain either
Grauer, Andreas
core   +1 more source