Results 71 to 80 of about 1,482,447 (317)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Mild and effective N-phthaloylation of amino acids

, 2004
In the present work various free amino acids, including tryptophan and tyrosine, were effectively N-phthaloylated under reduced pressure and at lower temperature.
Liu, Z, 曾庆乐, Zeng, Q, Li, B, Wang, F   +4 more
core  

Mechanisms of insulin secretion in malnutrition: modulation by amino acids in rodent models

, 2011
Protein restriction at early stages of life reduces beta-cell volume, number of insulin-containing granules, insulin content and release by pancreatic islets in response to glucose and other secretagogues, abnormalities similar to those seen in type 2 ...
Machado de Oliveira, Camila Aparecida, Latorraca, Marcia Queiroz, Oliveira, Camila Aparecida Machado de [UNIFESP], Carneiro, Everardo Magalhaes, Rostom de Mello, Maria Alice, Rostom de Mello, Maria Alice [UNESP]   +5 more
core   +1 more source

L-tyrosine inhibits the formation of amyloid fibers of human lysozyme at physiological pH and temperature

Amino Acids
Amyloid fibers are implicated in numerous diseases, making their study crucial for identifying effective therapeutic compounds. This research highlights the ability of L-tyrosine to inhibit the formation of amyloid fibers in human lysozyme.
Santos López, Arturo Rojo-Domínguez, Roxana López-Simeon, Alejandro Sosa-Peinado, Hugo Nájera   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Sex differences in amino acids lost via sweating could lead to differential susceptibilities to disturbances in nitrogen balance and collagen turnover

, 2017
Fluid collected during sweating is enriched with amino acids derived from the skin’s natural moisturising factors and has been termed “faux” sweat. Little is known about sex differences in sweat amino acid composition or whether faux sweat amino acid ...
Stevens, Christopher J, T. K. Roberts, Gottfries, C G, Dunstan, R H, Sparkes, D L, J. Gottfries, R. H. Dunstan, Murphy, G. R., Gottfries, J, M. M. Macdonald, Murphy, G R, Gottfries, J., Dascombe, Ben (R21089), C.-G. Gottfries, Roberts, T K, Sparkes, D. L., Stevens, Christopher J., C. J. Stevens, Dascombe, B. J., Gottfries, C. G., B. J. Dascombe, Dascombe, B J, Macdonald, M. M., Stevens, C. J., Dunstan, R. H., Roberts, T. K., Macdonald, M M, Gottfries, Johan,, D. L. Sparkes, Gottfries, C.-G., G. R. Murphy   +30 more
core   +1 more source

Exploring the therapeutic potential of L-arginine in chronic anal fissure management: a comprehensive review

Amino Acids
Anal fissure causes pain and bleeding during or after bowel movements, significantly impacting individuals’ quality of life. Current treatments aim to interrupt this cycle but have associated risks and limitations.
Nogol Motamed-Gorji, Mohsen Masoodi, Masoumeh Khalighi Sikaroudi, Shahram Agah, Nikta Masoodi   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Suzuki-Miyaura diversification of amino acids and dipeptides in aqueous media

, 2015
The authors gratefully acknowledge the IWT Flanders and Janssen Pharmaceutica for financial support of T.W. This work is supported by the Scientific Research Network (WOG) “Sustainable chemistry for the synthesis of fine chemicals” of the Research ...
Van Imp, Karolien, Herman W. T. Van Vlijmen, Bert U. W. Maes, Wim Schepens, Goss, Rebecca J. M., Van Vlijmen, Herman W. T., Rebecca J. M. Goss, Willemse, Tom, Ballet, Steven, Tom Willemse, Van Vlijmen, Herman W.T., Steven Ballet, Maes , Bert U.W., Van Imp , Karolien, Goss, Rebecca Jane Miriam, Maes, Bert, Karolien Van Imp, Schepens, Wim   +17 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source