Results 81 to 90 of about 2,550,027 (311)

4 Aromatic Amino Acids in the Brain

, 2007
This chapter describes the aromatic l-amino acids tryptophan and tyrosine and the effects on tyrosine metabolism of phenylalanine. Tryptophan and phenylalanine are essential amino acids and must ultimately be derived from dietary proteins; tyrosine is ...
M. Cansev, Cansev, Mehmet, R. J. Wurtman, Wurtman, Richard J.   +3 more
core   +1 more source

At the core of global bioenergy: polyamines and transglutaminases in chloroplasts

Amino Acids
Chloroplasts are the energy factories of photosynthetic life. The energy and the plant biomass of the planet depend on the activity of chloroplasts. Their efficiency results from a delicate balance between membrane organization, metabolic regulation and ...
Donatella Serafini-Fracassini, Stefano Del Duca   +1 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Diel rhythmicity in amino acid uptake by Prochlorococcus [PDF]

, 2008
The marine cyanobacterium Prochlorococcus, the most abundant phototrophic organism on Earth, numerically dominates the phytoplankton in nitrogen (N)-depleted oceanic gyres.
Terry, Matthew J, Garczarek, Laurence, Tarran, Glen A, Mary, Isabelle, Burkill, Peter H, Scanlan, David J, Kolowrat, Christian, Zubkov, MV, Zubkov, Mikhail V, Terry, MJ, Tarran, Glen A., Scanlan, David J., Scanlan, DJ, Burkill, Peter H., Tarran, GA, Terry, Matthew J., Burkill, PH, Zubkov, Mikhail V., Kolowrat, CK, Mary, I, Garczarek, LG   +20 more
core   +1 more source

Revisiting the antizyme 1 – ODC interaction reveals low-nanomolar affinity

Amino Acids
Ornithine decarboxylase (ODC) catalyzes the rate-limiting step in polyamine biosynthesis and is one of the shortest-lived mammalian proteins. Its activity and proteasomal degradation are controlled by antizyme (AZ), which disrupts the active ODC ...
Grzegorz P. Bereta, Elżbieta Wątor-Wilk, Paweł Kochanowski, Jakub Nowak, Tomasz Kantyka, Przemysław Grudnik   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Taurine supplementation and systemic lupus erythematosus in preclinical studies: a systematic review of clinical outcomes and underlying mechanisms

Amino Acids
Taurine (Tau) is a sulfur-containing amino acid that has therapeutic roles in several diseases, including inflammatory conditions. The involvement of Tau in modulating systemic lupus erythematosus (SLE) autoimmunity has been indicated in preclinical ...
Aida Malek Mahdavi, Zeinab Javadivala, Niloufar Orooji   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Order of amino acids in C-terminal cysteine-containing peptide-based chelators influences cellular processing and biodistribution of 99mTc-labeled recombinant Affibody molecules

, 2011
Affibody molecules constitute a novel class of molecular display selected affinity proteins based on non-immunoglobulin scaffold. Preclinical investigations and pilot clinical data have demonstrated that Affibody molecules provide high contrast imaging ...
Altai, Mohamed,, Wållberg, Helena, Rosestedt, Maria,, Helena Wållberg, Hosseinimehr, Seyed Jalal,, Vladimir Tolmachev, Tolmachev, Vladimir, Maria Rosestedt, Stefan Ståhl, Tolmachev, Vladimir,, Rosestedt, Maria, Ståhl, Stefan,, Mohamed Altai, Orlova, Anna, Wållberg, Helena,, Hosseinimehr, Seyed Jalal, Orlova, Anna,, Anna Orlova, Ståhl, Stefan, Altai, Mohamed, Seyed Jalal Hosseinimehr   +20 more
core   +1 more source

The role of N-acetylcysteine and glutathione in the management of Parkinson’s disease: a systematic review of oxidative biomarkers and clinical outcomes

Amino Acids
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons, leading to both motor and non-motor symptoms.
Imran Mohammed, Yasimin Nankya, U. Teng Hong, Amy Kan, Alya Masoud Abdelhafid, Gladys O. Latunde-Dada   +5 more
doaj   +1 more source