Results 111 to 120 of about 7,755,658 (385)

Metabolic alterations in diabetic patients: aqueous humor profiling for biomarker discovery

open access: yesAmino Acids
Diabetic retinopathy, a leading cause of vision loss in working-age populations, is a severe complication of diabetes mellitus. Metabolomics, a key approach in systems biology, offers insights into the complex pathophysiology of diabetes by analyzing low-
Arturs Zemitis   +6 more
doaj   +1 more source

Free amino acids of the blood and some organs in hypokinesia [PDF]

open access: yes
The metabolic fund of amino acids of the blood and tissues of rats under hypokinesia was investigated. The content of free amino acids was determined for the liver, kidney, brain, and the skeletal and cardiac muscles after established periods of ...
Kobylyanskiy, L. N.   +3 more
core   +1 more source

Amino acids

open access: yesBotanical Gazette, 1916
Amino acids are the basic structural building units of protein and other biomolecules; they are also utilized as an energy source. Daily intake of dietary protein is necessary to present tissue protein breakdown to supply the continuous, critical amino ...
Francesco Sciacca, Daniel Bell
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Exploring claudin proteins: from sequence motifs to their impact on tight junction-mediated signaling pathways

open access: yesAmino Acids
Claudin (CLDN) proteins are extensively studied due to their critical role in maintaining tissue barriers and cell polarity. However, significant gaps remain in understanding the functional mechanisms of their sequence motifs and the molecular mechanisms
Lingling Bao   +3 more
doaj   +1 more source

Regulation of autophagy by amino acids and MTOR-dependent signal transduction

open access: yesAmino Acids, 2014
Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction which controls the major metabolic pathways.
A. Meijer   +3 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Association of homoarginine with arginine and disease severity in COVID-19 patients

open access: yesAmino Acids
This study explored the relationship between the concentrations of homoarginine and arginine and between homoarginine concentration and laboratory parameters in coronavirus disease 2019 (COVID-19) patients with different severity to demonstrate the role ...
Zhiling Zhao   +13 more
doaj   +1 more source

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