Developing an Unnatural Amino Acid-Specific Aminoacyl tRNA Synthetase [PDF]
, 2018 Unnatural Amino Acids (UAAs), amino acids not present in the human genetic code, have been synthesized to have a broad range of useful properties, in this case, as metal-binders which could have drug delivery applications.
Mammoser, Claire C, Rowe, Laura
core +2 more sources
Stable Isotope Peptide Mass Spectrometry To Decipher Amino Acid Metabolism in Dehalococcoides Strain CBDB1 [PDF]
, 2012 Ernest Marco‐Urrea +3 more
openalex +1 more source
Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffeine and Amino Acids [PDF]
, 2020 Keiko Unno +8 more
openalex +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis
Amino AcidsIn the initial stages of Alopecia Areata (AA), the predominance of hair breakage or exclamation mark hairs serves as vital indicators of disease activity. These signs are non-invasive and are commonly employed in dermatoscopic examinations. Despite their
Wen Xu, Bo Xie, Dongfan Wei, Xiuzu Song
doaj +1 more source
Fatty Acid and Amino Acid Composition of Citrullus Colocynthis Seeds Growing in Algeria [PDF]
, 2021 Boulanouar Bakchiche +5 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Structure determination needs to go viral
Amino AcidsViral diseases are expected to cause new epidemics in the future, therefore, it is essential to assess how viral diversity is represented in terms of deposited protein structures.
Matheus de Bastos Balbe e Gutierres +3 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Altered amino acid levels in young hypopituitarism: impact of NAFLD and insulin resistance
Amino AcidsElevated concentrations of amino acids (AAs) are commonly observed in patients with nonalcoholic fatty liver disease (NAFLD). Individuals with hypopituitarism (HP) are at a heightened risk of developing NAFLD due to factors such as visceral obesity ...
Yuwen Zhang +3 more
doaj +1 more source