Results 141 to 150 of about 7,755,658 (385)

Polypeptide formation in clusters of β-alanine amino acids by single ion impact [PDF]

, 2020
Patrick Rousseau, Dariusz G. Piekarski, Michaël Capron, Alicja Domaracka, L. Adoui, Fernando Martı́n, Manuel Alcamı́, Sergio Díaz‐Tendero, Bernd Huber   +8 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Novel octapeptide containing the RGD sequence as a potential anti-SARS-CoV-2 agent: design, synthesis, and theoretical studies

Amino Acids
The design of peptide-based inhibitors targeting cell receptors represents a promising strategy in the development of antiviral agents. In this study, a novel octapeptide containing the RGD sequence was rationally designed to explore its potential ...
Reiner Lemos, Orlando Ortiz, Luis Almagro, Kamil Makowski, Hortensia Rodríguez, Fernando Albericio, Margarita Suarez   +6 more
doaj   +1 more source

Hydrothermal Decomposition of Amino Acids and Origins of Prebiotic Meteoritic Organic Compounds [PDF]

The organic compounds found in carbonaceous chondrite meteorites provide insight into primordial solar system chemistry. Evaluating the formation and decomposition mechanisms of meteoritic amino acids may aid our understanding of the origins of life and ...
Aponte, José C., Dworkin, Jason P., Elsila, Jamie E., Pietrucci, Fabio, Pérez-Villa, Andrea, Saitta, A. Marco, Starr, Richard   +6 more
core   +1 more source

Effects of nitrogen levels on gene expression and amino acid metabolism in Welsh onion [PDF]

, 2021
Chen Zhao, Guanchu Ma, Lin Zhou, Song Zhang, Le Su, Xin Sun, Orlando Borrás‐Hidalgo, Kunlun Li, Qiulin Yue, Lin Zhao   +9 more
openalex   +1 more source

Amino acid requirements and amino acid supply in the sheep [PDF]

Proceedings of the Nutrition Society, 1973
D. G. Armstrong, E. F. Annison
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls

Amino Acids
Creatine is a natural nitrogenous organic acid that is integral to energy metabolism and crucial for proper cell functioning. The kidneys are involved in the first step of creatine production. With kidney transplantation being the gold-standard treatment
Adrian Post, Dion Groothof, Daan Kremer, Tim J. Knobbe, Willem Abma, Christa A. Koops, Dimitrios Tsikas, Theo Wallimann, Robin P.F. Dullaart, Casper F.M. Franssen, Ido P. Kema, M. Rebecca Heiner-Fokkema, Stephan J.L. Bakker   +12 more
doaj   +1 more source

Factors affecting protein synthesis in vitro in rabbit reticulocytes [PDF]

, 1957
Rabbit reticulocytes in vitro rapidly incorporate labeled amino acids into their proteins. The process is accelerated by the plasma of every mammal investigated and also by extracts of normal erythrocytes, rabbit reticulocytes, liver, spleen, and yeast ...
Borsook, Henry, Fischer, Edmond H., Keighley, Geoffrey   +2 more
core  

Reduced Na⁺K⁺‐ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity [PDF]

, 2020
Jane Stremming, Thomas Jansson, Theresa L. Powell, Paul J. Rozance, Laura D. Brown   +4 more
openalex   +1 more source