Results 171 to 180 of about 7,358,369 (397)

Investigating metabolic dysregulation in serum of triple transgenic Alzheimer’s disease male mice: implications for pathogenesis and potential biomarkers

Amino Acids
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that lacks convenient and accessible peripheral blood diagnostic markers and effective drugs.
Hongbin Zhuang, Xueshan Cao, Xiaoxiao Tang, Yongdong Zou, Hongbo Yang, Zhiyuan Liang, Xi Yan, Xiaolu Chen, Xingui Feng, Liming Shen   +9 more
doaj   +1 more source

Hydrothermal Decomposition of Amino Acids and Origins of Prebiotic Meteoritic Organic Compounds [PDF]

The organic compounds found in carbonaceous chondrite meteorites provide insight into primordial solar system chemistry. Evaluating the formation and decomposition mechanisms of meteoritic amino acids may aid our understanding of the origins of life and ...
Aponte, José C., Dworkin, Jason P., Elsila, Jamie E., Pietrucci, Fabio, Pérez-Villa, Andrea, Saitta, A. Marco, Starr, Richard   +6 more
core   +1 more source

THE SEQUENCE OF AMINO ACIDS IN OXYTOCIN, WITH A PROPOSAL FOR THE STRUCTURE OF OXYTOCIN

, 1953
Vincent du Vigneaud, Charlotte Ressler, S. Trippett   +2 more
openalex   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Intersubunit communication in glycogen phosphorylase influences substrate recognition at the catalytic sites

Amino Acids
Glycogen phosphorylase (GP) is biologically active as a dimer of identical subunits, each activated by phosphorylation of the serine-14 residue. GP exists in three interconvertible forms, namely GPa (di-phosphorylated form), GPab (mono-phosphorylated ...
Nahori Kamada, Ayato Ikeda, Yasushi Makino, Hiroshi Matsubara   +3 more
doaj   +1 more source

SOME RELATIONSHIPS BETWEEN THE AMINO ACID CONTENTS OF PROTEINS AND THEIR NUTRITIVE VALUES FOR THE RAT

, 1946
H.H. Mitchell, Richard J. Block
openalex   +1 more source

Some biochemically relevant properties of N-substituted fructosamines derived from amino-acids and N-arylglucosylamines [PDF]

, 1953

openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Amino Acids
In the initial stages of Alopecia Areata (AA), the predominance of hair breakage or exclamation mark hairs serves as vital indicators of disease activity. These signs are non-invasive and are commonly employed in dermatoscopic examinations. Despite their
Wen Xu, Bo Xie, Dongfan Wei, Xiuzu Song
doaj   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source