Results 181 to 190 of about 2,480,811 (338)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Amino acids metabolism: a potential target for cancer treatment. [PDF]

Mol Cancer
Ren S, Zhou X, Wang Z, Yuan K.
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Branched chain amino acids prime metabolic inflammation. [PDF]

Mol Metab
Doshi NK, Pesaresi T, Pagadala T, Dion W, Zhang Y, David NL, Amorim T, Wang W, Kumar GVN, Zhu B, Liu S, Patwari P, Fazeli PK, Steinhauser ML.   +13 more
europepmc   +1 more source

Amino acid requirements [PDF]

Proceedings of the Nutrition Society, 1976
D, Lewis, D J, Cole
openaire   +2 more sources

Evaluation of β‐Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure

, 2017
D.E. Mortenson, Dale F. Kreitler, Nicole C. Thomas, Ilia A. Guzei, Samuel H. Gellman, Katrina T. Forest   +5 more
openalex   +2 more sources

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Oxidizable amino acids around cytochrome P450 hemes. [PDF]

J Inorg Biochem
Winkler JR.
europepmc   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Carbonylative Coupling of 1‑Iodoglucal and Amino Acids: Access to New Fluorescent Sugar Amino Acids. [PDF]

ACS Omega
Silva PM, Toledo MFZJ, Manarin F, Pimenta DC, Pereira NMO, Bastos EL, da Silva VM, Hornink MM, Stefani HA.   +8 more
europepmc   +1 more source