Results 141 to 150 of about 5,172,296 (338)

Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes

Neural Regeneration Research
Diabetic retinopathy is a prominent cause of blindness in adults, with early retinal ganglion cell loss contributing to visual dysfunction or blindness.
Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhong   +8 more
doaj   +1 more source

The neuropharmacology of baclofen [PDF]

, 1988
AI Shapovalov, B Ault, B Ault, B Ault, B Ault, B Ault, B Sutor, B Sutor, BH Gähwiler, BH Gähwiler, BW Connors, CF Terrence, CG Swahn, CN Scholfield, CR Cain, D Stevens, DR Curtis, DR Curtis, DR Curtis, DR Gehlert, DR Hill, E Cherubini, E Knutsson, E Mugnaini, E Roberts, E Schlicker, EW Karbon, FK Pierau, FK Pierau, GAR Johnston, GE Fagg, GGS Collins, GP Wilkin, GW Price, H Fukuda, H Keberle, H Möhler, H Ono, HJ Bein, HL Haas, HR Olpe, HR Olpe, HR Olpe, J Davies, J Davies, J Davies, J Swaynok, JJ Dreifuss, JL Henry, JL Henry, JL Henry, JR Bianchine, JR Howe, JW Phillis, K Dunlap, K Koketsu, K Krnjevic, KJ Fotherby, KS Saito, M Desarmenien, M Fillenz, M Inoue, M Inoue, M Kato, MA Simmonds, MR Klee, N Auden, N Ogata, NG Bowery, NG Bowery, NG Bowery, NG Bowery, NR Newberry, NR Newberry, NR Newberry, P Ashby, P Krogsgaard-Larsen, P Polc, PR Wilson, R Benecke, R Capek, RA Davidoff, RD Pinnock, RF Schmidt, RH Evans, RJ Brady, RR Young, RW Birkmayer, S Fox, SJ Enna, SJ Potashner, SJ Potashner, SR Barry, SR Zukin, TH Lanthorn, TJ Blaxter, U Heinemann, U Misgeld, V Ben-Ari, W Haefely, W Haefely, W Laskey, W Laskey, W Zieglgänsberger, WJ Wojcik   +104 more
core   +1 more source

Protective Action of γ-Aminobutyric Acid against Oxygen Toxicity [PDF]

, 1962
J. D. Wood, William J. Watson
openalex   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]

, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong, Jones, Emily A, Najm, Ramsey   +2 more
core   +1 more source

Resting‐state functional connectivity changes with microburst vagus nerve stimulation therapy

Epilepsia Open, EarlyView.
Abstract Objective Microburst vagus nerve stimulation (μVNS) may reduce seizure frequency in drug‐resistant epilepsy (DRE) via targeted thalamic plasticity. We prospectively investigated the role of thalamic resting‐state functional connectivity (rsFC) in μVNS effects and hypothesized a relationship between thalamic rsFC and long‐term seizure frequency
Jane B. Allendorfer, Rodolphe Nenert, Elhum Shamshiri, Giovanni Ranuzzi, Jason Begnaud, Ryan Verner, Jerzy P. Szaflarski, for the Microburst Study Group, Rebecca O’Dwyer, Michael Macken, Blake Newman, Cornelia Drees, Danielle McDermott, Lesley Kaye, Mesha Gay Brown, Muhammad Zafar, William Tatum, Selim Benbadis, Pegah Afra, Zeenat Jaisani, Kristl Vonck   +20 more
wiley   +1 more source

Metabolism of γ-Aminobutyric Acid in Brain Slices

, 1957
Yasuzo Tsukada, Yutaka Nagata, G. Takagaki   +2 more
openalex   +2 more sources

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Associations between the gut microbiota, immune cells, and different subtypes of epilepsy: A Mendelian randomization study

Epilepsia Open, EarlyView.
Abstract Objective The gut microbiota (GM) plays a role in epilepsy development via the microbiota–gut–brain axis. However, its relationship with various epilepsy subtypes and its mediating role through immune cells remain unclear. Thus, identifying the GM linked to specific epilepsy subtypes and investigating immune mechanisms to predict epilepsy risk,
Xu Zhang, Zhenlin Yang, Jingjing Guo, Yuanxin Wei, Jinzi Li   +4 more
wiley   +1 more source

ENZYMATIC RESOLUTION OF RACEMIC LYSINE, NORLEUCINE, NORVALINE, AND α-AMINOBUTYRIC ACID

, 1950
Jesse P. Greenstein, James B. Gilbert, Paul J. Fodor   +2 more
openalex   +1 more source