Results 161 to 170 of about 5,282,507 (400)

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

open access: yesIbrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen   +10 more
wiley   +1 more source

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis

open access: yesiMetaOmics, EarlyView.
Schematic representation of the distinct tumor microenvironment characteristics in CA1 and CA2 subtypes. CA1 illustrates an immune‐active tumor microenvironment characterized by elevated infiltration of immune cells, particularly CD8 + T cells and macrophages, and enhanced IFN‐γ signaling.
Shuting Xia   +14 more
wiley   +1 more source

An Intermediate State of the {gamma}-Aminobutyric Acid Transporter GAT1 Revealed by Simultaneous Voltage Clamp and Fluorescence [PDF]

open access: yes, 2000
The rat {gamma}-aminobutyric acid transporter GAT1 expressed in Xenopus oocytes was labeled at Cys74, and at one or more other sites, by tetramethylrhodamine-5-maleimide, without significantly altering GAT1 function.
Farley, Robert A.   +2 more
core   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

open access: yesiNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu   +10 more
wiley   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu   +6 more
wiley   +1 more source

Spectrophotometric study of the charge transfer complexation of some amino acid derivative drugs as electron donors with 7,7,8,8-tetracyanoquinodimethane

open access: yesBulletin of the Chemical Society of Ethiopia, 2010
Charge transfer (CT) complexes of some drugs of amino acid derivatives, such as carbocysteine, aminobutyric acid, and levodopa, as electron donors with 7,7,8,8-tetracyanoquinodimethane (TCNQ) as electron acceptor have been studied.
Sheng Yun Li   +4 more
doaj  

Association between the gut microbiome and neurodevelopmental outcomes in infants with congenital heart disease: A prospective cohort study

open access: yesJournal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Children with congenital heart disease are at risk for poor neurodevelopment. The gut microbiome may influence neurodevelopmental outcomes through the gut‐brain axis. This study investigated the association of early‐life gut microbiome with neurodevelopmental outcomes.
Michael P. Fundora   +11 more
wiley   +1 more source

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