Results 111 to 120 of about 69,960 (284)

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Experimental and Clinical Approaches to Preventing Aminoglycoside-Induced Ototoxicity: A Scoping Review

Antioxidants
(1) Aminoglycosides remain indispensable in modern medicine but share a serious dose-limiting adverse effect: irreversible cochleovestibular ototoxicity. (2) This scoping review systematically maps experimental and clinical strategies aimed at preventing
Marek Zadrożniak, Maciej Biskupski, Marcin Szymański, Jarogniew J. Łuszczki   +3 more
doaj   +1 more source

The Synergy Between a Silver-Ruthenium Antimicrobial and Aminoglycosides Is Based on Severe Macromolecular Damage. [PDF]

Mol Microbiol
AGXX enhances aminoglycoside activity against multidrug‐resistant pathogens such as uropathogenic Escherichia coli by increasing reactive oxygen species, causing protein aggregation and DNA damage. This effect is reduced by oxygen limitation or antioxidants. Polyphosphate protects cells from oxidative damage.
Oladokun EP, Donkor GY, Narh JK, Jacobson GD, Ward C, Tawiah PO, Polzer LK, Edwards KA, Floyd KA, Dahl JU.   +9 more
europepmc   +2 more sources

Newly identified human aminoacyl‐tRNA synthetase complex interacting multifunctional protein 2 (AIMP2) loss‐of‐function mutations cause neurodevelopmental defects linked to cell death in a zebrafish model

The FEBS Journal, EarlyView.
Human AIMP2 mutations lead to severe neurodevelopmental defects and brain atrophy. Using patient‐derived fibroblasts from two individuals, we show decreased AIMP2 protein levels and overall protein synthesis. In a zebrafish loss‐of‐function model, the lack of AIMP2 leads to an increase in cell death and results in smaller brains.
Patrick Mullen, Shenela Lakhani, Joshua Appelbaum, DéJenaé See, Pryce Patterson, Collin M. MacLeod, Alexandra George, Reza Maroofian, Margaret E. Ross, Christopher Francklyn, Alicia M. Ebert   +10 more
wiley   +1 more source

Aminoglycosides and kidney function [PDF]

Journal of Medical Biochemistry, 2007
The aminoglycosides are bactericide antibiotics with predominant effecting on the Gramm-negative bacterias, then staphylococci and mycobacteria with a small therapeutic range and with expressive ototoxic, nephrotoxic and with rare neurotoxic side effects.
Stanić Momčilo, Mitić Radoslav, Jakovljević Milan   +2 more
doaj  

Studies of Enzymes That Cause Resistance to Aminoglycosides Antibiotics

, 2008
Aminoglycoside antibiotics are highly potent, wide-spectrum bactericidals (1, 2). Bacterial resistance to aminoglycosides, however, is a major problem in the clinical use of aminoglycosides.
Özen, Can, Edward Wright, Serpersu, Engin H, Wright, Edward, Can Özen, Engin H. Serpersu   +5 more
core   +1 more source

Hypophosphataemia in adults: approach to diagnosis and management

Internal Medicine Journal, EarlyView.
Abstract Hypophosphataemia is a common electrolyte disorder which can have clinically significant consequences for bone, muscle, neurological and haematological function. Its causes range from transient transcellular shifts in hospitalised patients to chronic renal phosphate‐wasting disorders mediated by fibroblast growth factor 23 (FGF23).
Kajanan Parameshwaran, Mawson Wang, Kirtan Ganda   +2 more
wiley   +1 more source

Fluorinated aminoglycosides

ARKIVOC, 2019
Oscar M. Saavedra, Miguel A. Vilchis-Reyes   +1 more
doaj   +1 more source

Potentiation of Aminoglycoside Activity by A Pseudomonas aeruginosa Derived Enzyme Inhibitor against Multidrug-resistant Gram-positive Pathogens

Journal of Pure and Applied Microbiology
Multidrug-resistant (MDR) bacteria have posed a major clinical challenge, as many currently available antibiotics have lost their effectiveness. The development of new or improved antimicrobial formulations are required to address this problem. Collected
Mohammed S. Alosaimi
doaj   +1 more source

Temporal distribution of acute kidney injury–related hospitalizations after initiation of sodium–glucose cotransporter 2 inhibitors: A nationwide claims database analysis in older adults with an independent complementary single‐center eGFR analysis

Journal of Diabetes Investigation, EarlyView.
Among 190 older adults who experienced AKI‐related hospitalization after SGLT2 inhibitor initiation, 31.1% were hospitalized within 30 days. In an independent single‐center cohort, sustained early eGFR decline was associated with older age and use of one or two triple‐whammy‐related drug classes.
Kazuya Hiura, Ayana Tatsuno, Yamato Noto, Ryosuke Wakamatsu, Masayuki Sakunami, Ryu Kobayashi, Miki Yamashita   +6 more
wiley   +1 more source