Results 101 to 110 of about 66,693 (295)

Fluorinated aminoglycosides

ARKIVOC, 2019
Oscar M. Saavedra, Miguel A. Vilchis-Reyes   +1 more
doaj   +1 more source

Mechanisms, prevention, and management of aminoglycoside-induced hearing loss in neonates and children: a translational review

Frontiers in Pharmacology
ObjectiveAminoglycoside antibiotics remain essential for treating serious neonatal and pediatric infections, yet carry a well-documented risk of permanent auditory and vestibular toxicity.
Sílvia M. Illamola, Catherine M. Sherwin, Catherine M. Sherwin, Catherine M. Sherwin, Catherine M. Sherwin, Lauren C. Ferguson, Angela K. Birnbaum, Angela K. Birnbaum, Angela K. Birnbaum, Ravindhra G. Elluru, Janelle D. Vaughns, Janelle D. Vaughns   +11 more
doaj   +1 more source

Genetic dissection reveals distinct contributions of the eS31 N‐terminal domain to translational accuracy in Saccharomyces cerevisiae

The FEBS Journal, EarlyView.
The eukaryote‐specific N‐terminal domain (NTD) of eS31 uses two distinct strategies to maintain translation fidelity. During elongation, a positively charged “hotspot” fine‐tunes the selection of incoming aa‐tRNA. During termination, the entire NTD acts as a structural scaffold to ensure the correct positioning of the release factor eRF1.
Qingxuan Gao, Hiroshi Otsuka, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Cryo‐EM structures of multiple‐peptide resistance factor (MprF) from Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
Cryo‐EM analysis of MprF from Pseudomonas aeruginosa reveals a dimeric enzyme, distinct from Rhizobium homologues. The soluble GNAT domain contains a dynamic amphipathic helix (TTH) that adopts different positions in detergent micelle and nanodisc, relative to the membrane.
Shaileshanand Jha, Kutti R. Vinothkumar
wiley   +1 more source

Potentiation of Aminoglycoside Activity by A Pseudomonas aeruginosa Derived Enzyme Inhibitor against Multidrug-resistant Gram-positive Pathogens

Journal of Pure and Applied Microbiology
Multidrug-resistant (MDR) bacteria have posed a major clinical challenge, as many currently available antibiotics have lost their effectiveness. The development of new or improved antimicrobial formulations are required to address this problem. Collected
Mohammed S. Alosaimi
doaj   +1 more source

Designer Aminoglycosides That Selectively Inhibit Cytoplasmic Rather than Mitochondrial Ribosomes Show Decreased Ototoxicity [PDF]

, 2013
Eli Shulman, Valery Belakhov, Gao Wei, Ann Kendall, Esther G. Meyron‐Holtz, Dorit Ben‐Shachar, Jochen Schacht, Timor Baasov   +7 more
openalex   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Hypomagnesaemic tetany associated with prolonged treatment with aminoglycosides. [PDF]

, 1986
Robert W. Wilkinson, Gameiro Lucas, David A. Heath, I M Franklin, B. J. Boughton   +4 more
openalex   +1 more source

Clinical Prediction Models for Acute Kidney Injury in Neonatology—A Systematic Review and Modelling Analysis

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aims Acute kidney injury (AKI) affects up to one‐third of neonates admitted to neonatal intensive care units (NICUs). NICUs are highly data‐rich environments, offering opportunities to develop clinical prediction rules (CPRs) that use clinical and demographic data to estimate AKI risk.
Dermot Wildes, Lisa Corley, Deirdre O'Sullivan, David T. Selewski, Caoimhe Costigan, Atif Awan, Catherine Quinlan, Michael A. Boyle   +7 more
wiley   +1 more source

Co-occurrence of aminoglycoside resistance gene armA in non-Typhi Salmonella isolates producing CTX-M-15 in Algeria [PDF]

, 2011
N. Bouzidi, Leila Aoun, Mazouz Dekhil, Sophie A. Granier, Laurent Poirel, Anne Brisabois, Patrice Nordmann, Yves Millemann   +7 more
openalex   +1 more source