Results 81 to 90 of about 69,960 (284)

Electrostatic Interactions in RNA Aminoglycosides Binding

open access: yes, 2016
Electrostatic Interactions in RNA Aminoglycosides ...
Hai Wang (310051), Yitzhak Tor (1339890)
core   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

open access: yesmLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei   +7 more
wiley   +1 more source

Antibacterial Effect of the In Vitro Interaction Between Clotrimazole and Chlorhexidine Against Staphylococcus pseudintermedius With Known Resistance Patterns Isolated From Canine Pyoderma. [PDF]

open access: yesVet Med Sci
The 2:1 chlorhexidine–clotrimazole combination demonstrated enhanced antibacterial activity against canine Staphylococcus pseudintermedius isolates, including resistant strains. Reduced MIC values, predominantly additive interactions and absence of antagonism support its use as a promising topical strategy for canine pyoderma management.
Gallegos-Torres B   +3 more
europepmc   +2 more sources

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

open access: yesSmall, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen   +9 more
wiley   +1 more source

Programmable 3D Microfluidics Reveals Motility‐Driven Antibiotic Resistance Evolution in Gradients

open access: yesSmall, EarlyView.
Using a programmable microfluidic platform, this study shows that bacterial motility is crucial for resistance development in heterogeneous antibiotic landscapes. Motile Escherichia coli randomly migrates along antibiotic gradients, and sufficient movement is required for resistance to emerge.
Xiaobo Li   +8 more
wiley   +1 more source

Filtration‐Based SERS With In Situ Gold Growth in Bacterial Microenvironment for Rapid Detection of Low‐Level Bacteria

open access: yesSmall Methods, EarlyView.
A filtration‐assisted SERS platform integrating in situ gold growth within the bacterial microenvironment enables rapid and highly sensitive detection of low‐level bacteria in complex biological matrices. By overcoming hotspot–bacteria mismatch, the platform simultaneously achieves selective bacterial identification and rapid antimicrobial ...
Eun‐Bi Jang   +3 more
wiley   +1 more source

Recent Advances in Optical Detection of Aminoglycosides

open access: yesApplied Sciences, 2020
Aminoglycosides (AGs) are broad-spectrum antibiotics used in both human infection and animal medicine. The overuse of AGs causes undesirable residues in food, leading to serious health problems due to food chain accumulation.
Yan Zhou, Yanwei Ji, Zhijuan Cao
doaj   +1 more source

Isolation of carbapenem‐resistant Pseudomonas aeruginosa and other Gram‐negative ESKAPE organisms from samples of raw‐meat diets for dogs in the UK

open access: yesVeterinary Record, EarlyView.
Abstract Background Gram‐negative ESKAPE organisms are an emerging threat in veterinary medicine that also have zoonotic potential. However, little is known about the prevalence and risks of these organisms in pet food. We present the incidental finding of gram‐negative ESKAPE organisms within samples of raw meat diets for dogs in the United Kingdom ...
Genever Morgan   +5 more
wiley   +1 more source

Clinical Features and Outcomes of Chronic Otitis Media Complications: A 20‐Year Retrospective Study at a Tertiary Hospital

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Chronic otitis media (COM) is a major public health concern, particularly in developing countries. Although complications have decreased with modern antibiotics, they still cause significant morbidity and mortality. This study analyzed the clinical features, bacteriological profiles, and treatment outcomes of COM complications at a ...
Viraporn Atchariyasathian   +1 more
wiley   +1 more source

Pharmacokinetic and pharmacodynamic influences of aminoglycoside dosing

open access: yes, 2011
Examines how the absorbtion and distribution of aminoglycosides within the body affects the dosing regimens used.

core  

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