Results 81 to 90 of about 56,556 (236)

Experimental and Clinical Approaches to Preventing Aminoglycoside-Induced Ototoxicity: A Scoping Review

Antioxidants
(1) Aminoglycosides remain indispensable in modern medicine but share a serious dose-limiting adverse effect: irreversible cochleovestibular ototoxicity. (2) This scoping review systematically maps experimental and clinical strategies aimed at preventing
Marek Zadrożniak, Maciej Biskupski, Marcin Szymański, Jarogniew J. Łuszczki   +3 more
doaj   +1 more source

Aminoglycosides and kidney function [PDF]

Journal of Medical Biochemistry, 2007
The aminoglycosides are bactericide antibiotics with predominant effecting on the Gramm-negative bacterias, then staphylococci and mycobacteria with a small therapeutic range and with expressive ototoxic, nephrotoxic and with rare neurotoxic side effects.
Stanić Momčilo, Mitić Radoslav, Jakovljević Milan   +2 more
doaj  

Cryo‐EM structures of multiple‐peptide resistance factor (MprF) from Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
Cryo‐EM analysis of MprF from Pseudomonas aeruginosa reveals a dimeric enzyme, distinct from Rhizobium homologues. The soluble GNAT domain contains a dynamic amphipathic helix (TTH) that adopts different positions in detergent micelle and nanodisc, relative to the membrane.
Shaileshanand Jha, Kutti R. Vinothkumar
wiley   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Fluorinated aminoglycosides

ARKIVOC, 2019
Oscar M. Saavedra, Miguel A. Vilchis-Reyes   +1 more
doaj   +1 more source

Phenotypic Florfenicol Resistance in floR‐Harbouring Flavobacterium psychrophilum Isolates (CC‐ST90): A Case Study From Danish Freshwater Rainbow Trout Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley   +1 more source

Potentiation of Aminoglycoside Activity by A Pseudomonas aeruginosa Derived Enzyme Inhibitor against Multidrug-resistant Gram-positive Pathogens

Journal of Pure and Applied Microbiology
Multidrug-resistant (MDR) bacteria have posed a major clinical challenge, as many currently available antibiotics have lost their effectiveness. The development of new or improved antimicrobial formulations are required to address this problem. Collected
Mohammed S. Alosaimi
doaj   +1 more source

Isolation and Identification of Erysipelothrix sp. in Hybrid Grouper (Epinephelus fuscoguttatus × E. lanceolatus) in Taiwan

Journal of Fish Diseases, EarlyView.
ABSTRACT In February 2025, a mortality event of unknown aetiology occurred at a hybrid grouper (Epinephelus fuscoguttatus × Epinephelus lanceolatus) aquaculture farm in southern Taiwan, with sporadic daily deaths persisting for a month. Four moribund groupers were collected over three sampling intervals for diagnostic investigation.
Shang‐Ting Wu, Yu‐Siang Lin, Chia‐Yu Hsieh   +2 more
wiley   +1 more source

Clinical Prediction Models for Acute Kidney Injury in Neonatology—A Systematic Review and Modelling Analysis

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aims Acute kidney injury (AKI) affects up to one‐third of neonates admitted to neonatal intensive care units (NICUs). NICUs are highly data‐rich environments, offering opportunities to develop clinical prediction rules (CPRs) that use clinical and demographic data to estimate AKI risk.
Dermot Wildes, Lisa Corley, Deirdre O'Sullivan, David T. Selewski, Caoimhe Costigan, Atif Awan, Catherine Quinlan, Michael A. Boyle   +7 more
wiley   +1 more source

Neonatal Acute Kidney Injury—An Australian and New Zealand Perspective

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Acute kidney injury (AKI) is increasingly recognized as a critical and underdiagnosed condition among neonates, with significant short and long‐term implications for survival, kidney function, and long‐term cardiovascular health. Neonatal physiology, including ongoing nephrogenesis, immature renal haemodynamics, and limited glomerular ...
Saumil Desai, Thomas Forbes, Simon A. Carter, Alison L. Kent, Chanel Prestidge, David T. Selewski, Eveline Staub, Anke Raaijmakers   +7 more
wiley   +1 more source