Results 31 to 40 of about 1,424 (153)

Safety evaluation of an extension of use of the food enzyme glutaminase from the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT

EFSA Journal, Volume 22, Issue 7, July 2024.
Abstract The food enzyme glutaminase (l‐glutamine amidohydrolase; EC 3.5.1.2) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT by Amano Enzyme Inc. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in five food ...
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Yrjö Roos, Daniele Cavanna, Yi Liu, Giulio di Piazza, Andrew Chesson   +22 more
wiley   +1 more source

Safety evaluation of the food enzyme glutaminase from the genetically modified Bacillus licheniformis strain NZYM‐JQ

EFSA Journal, Volume 22, Issue 4, April 2024.
Abstract The food enzyme glutaminase (l‐glutamine amidohydrolase EC 3.5.1.2) is produced with the genetically modified Bacillus licheniformis strain NZYM‐JQ by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The production strain met the requirements for the qualified presumption of safety (QPS).
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Yrjö Roos, Magdalena Andryszkiewicz, Ana Criado, Ana Gomes, Yi Liu, Daniele Cavanna, Giulio di Piazza, Andrew Chesson   +25 more
wiley   +1 more source

The role of glutamate and glutamine metabolism and related transporters in nerve cells

CNS Neuroscience &Therapeutics, Volume 30, Issue 2, February 2024.
The glutamate (Glu)‐glutamine (Gln) cycle between neurons and astrocytes, facilitated by cell surface transporters, plays a pivotal role in regulating synaptic glutamate levels, thereby influencing excitatory transmission. Moreover, glutamate serves as a carbon donor to generate α‐ketoglutarate (α‐KG), acts as a nitrogen donor for the synthesis of non ...
Dongyang Zhang, Zhongyan Hua, Zhijie Li
wiley   +1 more source

Microbes Producing L-Asparaginase free of Glutaminase and Urease isolated from Extreme Locations of Antarctic Soil and Moss

Scientific Reports, 2019
L-Asparaginase (L-asparagine aminohydrolase, E.C. 3.5.1.1) has been proven to be competent in treating Acute Lymphoblastic Leukaemia (ALL), which is widely observed in paediatric and adult groups.
Anup Ashok, K. Doriya, J. Rao, Asif Qureshi, A. Tiwari, D. Kumar   +5 more
semanticscholar   +1 more source

Safety evaluation of the food enzyme glutaminase from the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT

EFSA Journal, Volume 22, Issue 2, February 2024.
Abstract The food enzyme glutaminase (l‐glutamine amidohydrolase; EC 3.5.1.2) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT by Amano Enzyme Inc. The production strain met the requirements for the qualified presumption of safety (QPS) approach.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Claude Lambré, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu, Simone Lunardi, Elsa Nielsen, Karin Norby, Giulio di Piazza, Yrjö Roos, Andrew Chesson   +27 more
wiley   +1 more source

Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity

Advanced Science, Volume 11, Issue 3, January 19, 2024.
This review provides a comprehensive overview of the nanotechnology assisted PCD routes resulting in antitumor immunity including ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis, systematically introduces their therapeutic mechanisms, nanocarrier types as well as immune cell types, highlights the challenges and perspectives ...
Yongjuan Li, Yichen Guo, Kaixin Zhang, Rongrong Zhu, Xiaoyuan Chen, Zhenzhong Zhang, Weijing Yang   +6 more
wiley   +1 more source

Biochemical and genomic evidence for converging metabolic routes of metformin and biguanide breakdown in environmental Pseudomonads

Journal of Biological Chemistry
Metformin is commonly used to lower blood glucose levels and is one of the most widely used pharmaceuticals worldwide. Typical doses are high (0.5–2.0 g day−1) and the majority travels through the digestive system unabsorbed and enters the wastewater ...
Katie B Wissbroecker, Anthony J Zmuda, Harsheeth Karumanchi, Thomas D. Niehaus   +3 more
semanticscholar   +1 more source

Characterization of a Fatty Acid Amide Hydrolase (FAAH) in Hirudo verbana

Research Square
The endocannabinoid system plays a critical role in modulating both peripheral and central nervous system function. Despite being present throughout the animal kingdom, there has been relatively little investigation of the endocannabinoid system beyond ...
Emily J. Kabeiseman, Riley T. Paulsen, Brian D Burrell   +2 more
semanticscholar   +1 more source

Effects of lactate, ammonia, inorganic phosphate, potassium, pH, pCO2 and pO2 on the activities of adenosine and AMP aminohydrolases from skeletal and cardiac muscles.

Tohoku journal of experimental medicine, 1973
K. Watanabe, S. Tominaga, T. Nakamura
semanticscholar   +1 more source

Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39

Proceedings of the National Academy of Sciences of the United States of America, 2011
Lok-To Sham, Skye M. Barendt, K. Kopecky, M. Winkler   +3 more
semanticscholar   +1 more source