Results 161 to 170 of about 6,120 (213)

Synthesis of Highly Functionalized 4‐Aminoquinolines

Angewandte Chemie - International Edition, 2016
AbstractA diverse set of highly substituted 4‐aminoquinolines was synthesized from ynamides, triflic anhydride, 2‐chloropyridine, and readily accessible amides in a mild one‐step procedure.
Tim Wezeman, Sabilla Zhong, Martin Nieger   +2 more
exaly   +4 more sources

8-Aminoquinolines as anticoccidials — II

Bioorganic & Medicinal Chemistry Letters, 1998
During a chemistry program aimed at finding a novel analogue of pentaquine with improved in vivo activity, a number of hypotheses concerning the way this drug acts in the chicken were investigated. Consideration of the products of monoamine oxidase metabolism of pentaquine suggested that pentaquine aldehyde is the likely active metabolite.
R E, Armer, J S, Barlow, C J, Dutton, D H, Greenway, S D, Greenwood, N, Lad, A P, Thompson, K W, Thong, I, Tommasini   +8 more
openaire   +2 more sources

New Aminoquinoline with Schistosomicidal Activity

Nature, 1967
DURING routine testing of compounds, we have discovered schistosomicidal activity in a series of 5-aminoquinolines. Many compounds with this general formula were made and tested and some were found to have activity, but one compound was outstanding. This was 6-chloro-5-β-diethylaminoethylamino-8-methylquinoline.
N W, Bristow, B, Lessel, H C, Richards, G A, Williams   +3 more
openaire   +2 more sources

Porphyrin—Aminoquinoline Conjugates as Telomerase Inhibitors.

ChemInform, 2003
A series of metalloporphyrins was prepared in order to target the G-quadruplex structure of telomeric DNA for the design of antitelomerase compounds. The initial cationic tetramethylpyridiniumyl porphyrin was modified by the replacement of one or two methylpyridiniumyl groups by one or two 4-aminoquinoline moieties, at the meso position, in order to ...
Alexandrine, Maraval, Sonia, Franco, Corine, Vialas, Geneviève, Pratviel, Maria A, Blasco, Bernard, Meunier   +5 more
openaire   +2 more sources

Infrared study of the hydrogen bonding ability of 3-aminoquinoline and 8-aminoquinoline

Vibrational Spectroscopy, 1995
Abstract The geometry and the complexing ability of 3-aminoquinoline (3-AQ) and 8-aminoquinoline (8-AQ) are investigated by infrared spectrometry in carbon tetrachloride solution. The study of the NH(D) stretching vibrations in partially N-deuterated 8-AQ suggests that the two NH(D) bonds are not equivalent and this is accounted for by the presence ...
N. Leroux, M. Goethals, Th. Zeegers-Huyskens   +2 more
openaire   +1 more source

The cinchona alkaloids and the aminoquinolines

2020
The bark of the cinchona tree was first employed to treat malaria in Europe during the 15th century. Its active ingredients are natural products that are collectively known as the cinchona alkaloids and include quinine. In the 17th century, quinine became the first mass produced pharmaceutical agent and is still in use today for the treatment of ...
Rawe, Sarah Louise, McDonnell, Claire
openaire   +2 more sources

8-aminoquinolines as anticoccidials - part III

Bioorganic & Medicinal Chemistry Letters, 1999
Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated.
R E, Armer, J S, Barlow, N, Chopra, C J, Dutton, D H, Greenway, S D, Greenwood, N, Lad, J, Shaw, A P, Thompson, K W, Thong, I, Tommasini   +10 more
openaire   +2 more sources

Fluorescence and phosphorescence of 5- and 8-aminoquinoline

Analytica Chimica Acta, 1971
Abstract 5-Aminoquinoline and 8-aminoquinoline fluoresce moderately to weakly in low dielectric media but not in strongly hydrogen-bonding or acidic aqueous media. At low temperatures and in rigid media moderately intense fluorescence is observed in aqueous, media at all pH values.
S G, Schulman, L B, Sanders
openaire   +2 more sources

Photochromism and thermochromism of Sn(IV) complexes with 8-aminoquinoline and salicylidene-8-aminoquinoline

Thermochimica Acta, 1994
Abstract Tin(IV) complexes with 8-aminoquinoline (complexes (1) and (2)) and with salicylidene-8-aminoquinoline (complex (3)) have been prepared and characterized. Complexes (1) and (3) are thermochromic, and display irreversible and reversible thermochromism, respectively.
Ahmed M. Donia, Hanaa El-Boraey
openaire   +1 more source

Polymer micro-environmental effects on the fluorescence characteristics of 5-aminoquinoline and 3-aminoquinoline

Journal of Luminescence, 2012
Abstract In this paper we report the spectral and decay behavior of two probes viz. 5-aminoquinoline (5AQ) and 3-aminoquinoline (3AQ) in three different polymeric systems viz. poly methyl methacrylate (PMMA), polyvinyl alcohol (PVA) and cellulose acetate (CA).
J.P. Bridhkoti, H.C. Joshi, S. Pant
openaire   +1 more source