Results 21 to 30 of about 63,089 (245)

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

CASE STUDY EFFECTIVNESS OF AMYODARON USE IN PATIENTS WITH SUPRAVENTRICULAR TACHYCARDIA AND HYPOTHYROIDISM

Medical and Health Science Journal, 2019
A woman, 53 years of age, with recurrent supraventricular tachycardia (SVT) with hypothyroidism was thought to be associated with amiodarone use. Patients repeatedly get amiodarone for their arrhythmias, where amiodarone has a broad antiarrhythmic
,Ardyarini Dyah Savitri
doaj   +1 more source

Increased serum amiodarone concentration in hypertriglyceridemic patients: Effects of drug distribution to serum lipoproteins

Clinical and Translational Science, 2022
Amiodarone and its main metabolite, desethylamiodarone (DEA), are highly distributed to serum lipoproteins such as very‐low‐density lipoprotein (VLDL) and low‐density lipoprotein (LDL), which are the carriers of triglyceride and cholesterol.
Naoaki Hashimoto, Kosuke Doki, Satoru Kawano, Kazutaka Aonuma, Masaki Ieda, Masato Homma   +5 more
doaj   +1 more source

Amiodarone-related Pneumonitis

Journal of the Formosan Medical Association, 2007
Amiodarone-related pneumonitis is a potentially limiting factor for amiodarone usage. However, it is believed that amiodarone-related pneumonitis is unlikely to occur during low-dose and short courses of therapy. We report three patients who received low-
Sheng-Nan Chang, Juey-Jen Hwang, Kuan-Lih Hsu, Chia-Ti Tsai, Ling-Ping Lai, Jiunn-Lee Lin, Chuen-Den Tseng, Fu-Tien Chiang   +7 more
doaj   +1 more source

Autophagy alleviates amiodarone-induced hepatotoxicity

Archives of Toxicology, 2020
Amiodarone is a widely used antiarrhythmic drug that can cause the development of steatohepatitis as well as liver fibrosis and cirrhosis. The molecular mechanisms of amiodarone-mediated liver injury remain largely unknown.
F. Wandrer, Ž. Frangež, S. Liebig, K. John, F. Vondran, H. Wedemeyer, C. Veltmann, T. Pfeffer, O. Shibolet, K. Schulze-Osthoff, H. Simon, H. Bantel   +11 more
semanticscholar   +1 more source

Lipid emulsion mitigates intravenous amiodarone toxicity in a rat model

Toxicology Communications, 2022
Introduction Our study investigated whether lipid emulsion therapy could act as an antidote for intravenous amiodarone toxicity in a rat model.Methods 20 rats were randomised to receive lipid emulsion (ILE) or saline. Rats were infused with amiodarone at
Rachael Stewart, Verity Newman, Martyn Harvey, Mingtan Tang, Zimei Wu, Grant Cave   +5 more
doaj   +1 more source

Amiodarone alters cholesterol biosynthesis through tissue-dependent inhibition of EBP and DHCR24.

ACS Chemical Neuroscience, 2020
Amiodarone is prescribed for the treatment and prevention of irregular heartbeats. Although effective in clinical practice, the long-term use of amiodarone has many unwanted side effects, including cardiac, pulmonary, hepatic and neurological toxicities.
Luke B. Allen, Thiago C. Genaro-Mattos, Allison C. Anderson, N. Porter, K. Mirnics, Ž. Korade   +5 more
semanticscholar   +1 more source

Impact of amiodarone on plasma concentration of direct oral anticoagulant in patients with atrial fibrillation

Journal of the Formosan Medical Association, 2023
Background/purpose: Amiodarone increases exposure of direct oral anticoagulants (DOACs). We aimed to analyze the effects of concurrent amiodarone use on DOAC concentrations and clinical outcomes.
Shin-Yi Lin, Yen-Bin Liu, Li-Ting Ho, Yu-Fong Peng, Ching-Hua Kuo, Sung-Chun Tang, Chih-Fen Huang, Jiann-Shing Jeng   +7 more
doaj   +1 more source

Amiodarone Use and All‐Cause Mortality in Patients With a Continuous‐Flow Left Ventricular Assist Device

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Atrial and ventricular arrhythmias are commonly encountered in patients with advanced heart failure, with amiodarone being the most commonly used antiarrhythmic drug in continuous‐flow left ventricular assist device (CF‐LVAD) recipients.
Rakesh Gopinathannair, Naga Venkata K. Pothineni, Jaimin R. Trivedi, Henri Roukoz, Jennifer Cowger, Mustafa M. Ahmed, Adarsh Bhan, Ashwin K. Ravichandran, Geetha Bhat, Amin Al Ahmad, Andrea Natale, Luigi Di Biase, Mark S. Slaughter, Dhanunjaya Lakkireddy   +13 more
doaj   +1 more source

Cardiomyocyte-Targeting Peptide to Deliver Amiodarone

Pharmaceutics, 2023
Background: Amiodarone is underutilized due to significant off-target toxicities. We hypothesized that targeted delivery to the heart would lead to the lowering of the dose by utilizing a cardiomyocyte-targeting peptide (CTP), a cell-penetrating peptide ...
Maliha Zahid, Beth Weber, Ray Yurko, Kazi Islam, Vaishavi Agrawal, Jack Lopuszynski, Hisato Yagi, Guy Salama   +7 more
doaj   +1 more source