Results 51 to 60 of about 71,233 (300)

Thromboembolic and neurologic sequelae of discontinuation of an antihyperlipidemic drug during ongoing warfarin therapy [PDF]

, 2017
Warfarin and antihyperlipidemics are commonly co-prescribed. Some antihyperlipidemics may inhibit warfarin deactivation via the hepatic cytochrome P450 system.
Bilker, Warren B., Brensinger, Colleen M., Hennessy, Sean, Kimmel, Stephen E., Leonard, Charles E., Whitaker, Heather J.   +5 more
core   +2 more sources

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Amiodarone-Induced Pulmonary Toxicity in a Patient With Paroxysmal Atrial Fibrillation and Recurrence of Pulmonary Toxicity

Van Tıp Dergisi, 2022
Amiodarone is an effective anti-arrhythmic agent widely used for management of supraventricular and ventricular arrhythmias. Amiodarone-induced pulmonary toxicity is one of the most serious side effects of amiodarone therapy.
Nuri Köse, Tarık Yıldırım
doaj   +1 more source

Suspected hepatotoxicity effect of amiodarone (amiodarone and liver) [PDF]

Serbian Journal of Anesthesia and Intensive Therapy, 2017
Introduction: Acute hepatotoxicity is a rare but potentially fatal complication of amiodarone use. We report a case of liver injury after intravenous amiodarone administration in a patient with atrial fibrillation after heart surgery. Case report: A 62-year-old man with a history of dissection of the ascending aortic aneurysm presented for emergency ...
Miomir Jovic, Petar Vukovic, Dragana Unic-Stojanovic, Milja Tanasic   +3 more
openaire   +2 more sources

Local sensitivity analysis of a supercritical extraction model

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study investigates the process of chamomile oil extraction from chamomile flowers. A parameter‐distributed model, consisting of a set of partial differential equations, was used to describe the governing mass transfer phenomena between solid and fluid phases under supercritical conditions using carbon dioxide as the solvent.
Oliwer Sliczniuk, Pekka Oinas
wiley   +1 more source

L-Carnitine Ameliorates Amiodarone-Mediated Alveolar Damage: Oxidative Stress Parameters, Inflammatory Markers, Histological and Ultrastructural Insights

Pharmaceuticals
The aim of this study was to assess L-carnitine’s effects on adult male rats’ lung damage brought on by amiodarone, which is a potent antiarrhythmic with limited clinical efficacy due to potentially life-threatening amiodarone-induced lung damage ...
Samy A. Dawood, Ali Alsuheel Asseri, Ayed A. Shati, Refaat A. Eid, Basiouny El-Gamal, Mohamed Samir A. Zaki   +5 more
doaj   +1 more source

Too Little, Too Late: A Case of a Swift Fatal Culmination of Amiodarone Induced Pulmonary Toxicity in an Adult Male

International Medical Case Reports Journal, 2023
Clement Tan, Pranav Kumar Department of Respiratory Medicine, Mackay Base Hospital, Mackay, Queensland, AustraliaCorrespondence: Clement Tan; Pranav Kumar, Email Clement.Tan@health.qld.gov.au; Pranav.Kumar@health.qld.gov.auAbstract: Amiodarone is a ...
Tan C, Kumar P
doaj  

Amiodarone and Thyroid Dysfunction

Acta Clinica Croatica, 2022
Thyroid gland has a key role in maintaining the body homeostasis. Thyroxine is the main hormone secreted from the thyroid gland, its effect being predominantly achieved after the intracellular conversion of thyroxine to triiodothyronine, which exhibits a higher affinity for the receptor complex, thus modifying gene expression of the target cells ...
Medić, Filip, Bakula, Miro, Alfirević, Maša, Bakula, Maja, Mucić, Katarina, Marić, Nikolina   +5 more
openaire   +4 more sources

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Epicardial electrical heterogeneity after amiodarone treatment increases vulnerability to ventricular arrhythmias under therapeutic hypothermia

PLoS ONE, 2023
Background Amiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH ...
Chin-Yu Lin, Ting-Yung Chang, Yu-Feng Hu, Yu-Cheng Hsieh, Yi-Jen Chen, Hung-I Yeh, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Ta-Chuan Tuan, Shih-Ann Chen   +13 more
doaj   +2 more sources