Results 1 to 10 of about 36,705 (184)

Comparison of Amitriptyline and US Food and Drug Administration–Approved Treatments for Fibromyalgia

open access: yesJAMA Network Open, 2022
This systematic review and network meta-analysis compares amitriptyline with Food and Drug Administration–approved treatments for fibromyalgia related to sleep, fatigue, and health-related quality of life outcomes.
Hussein M Farag   +5 more
semanticscholar   +1 more source

The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction

open access: yesCardiovascular Drugs and Therapy, 2022
Inflammation associated endothelial cell (EC) dysfunction is key to atherosclerotic disease. Recent studies have demonstrated a protective role of amitriptyline in cardiomyocytes induced by hypoxia/reoxygenation.
Yang Ji   +12 more
semanticscholar   +1 more source

Amitriptyline blocks innate immune responses mediated by toll‐like receptor 4 and IL‐1 receptor: Preclinical and clinical evidence in osteoarthritis and gout

open access: yesBritish Journal of Pharmacology, 2021
Osteoarthritis, a major cause of disability in developed countries does not have effective treatment. Activation of TLR4 and innate immune response factors contribute to osteoarthritis progressive cartilage degradation.
E. Franco-Trepat   +9 more
semanticscholar   +1 more source

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients

open access: yesFrontiers in Pharmacology, 2021
The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
J. Matthaei   +9 more
semanticscholar   +1 more source

Sensitizing TRAIL-resistant A549 lung cancer cells and enhancing TRAIL-induced apoptosis with the antidepressant amitriptyline

open access: yesOncology Report, 2021
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with the potential to induce cancer cell-specific apoptosis with minimal toxicity to normal cells. Therefore, the resistance of certain cancer cells to TRAIL is a major concern
K. Zinnah, Sang-Youel Park
semanticscholar   +1 more source

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

open access: yesmBio, 2020
Efflux pumps of the resistance nodulation-cell division (RND) superfamily are major contributors to multidrug resistance for most of the Gram-negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii ...
E. Grimsey   +10 more
semanticscholar   +1 more source

Interacting Effects of Polystyrene Microplastics and the Antidepressant Amitriptyline on Early Life Stages of Brown Trout (Salmo trutta f. fario)

open access: yesWater, 2020
Whether microplastics themselves or their interactions with chemicals influence the health and development of aquatic organisms has become a matter of scientific discussion. In aquatic environments, several groups of chemicals are abundant in parallel to
Hannah Schmieg   +7 more
semanticscholar   +1 more source

Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells

open access: yesCell Death and Disease, 2020
Amitriptyline is a tricyclic antidepressant commonly prescribed for major depressive disorders, as well as depressive symptoms associated with various neurological disorders.
Y. Kwon   +4 more
semanticscholar   +1 more source

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