A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia [PDF]
Biomedicines, 2017 Fibromyalgia is a complex chronic condition characterized by pain, physical fatigue, sleep disorder and cognitive impairment. Evidence-based guidelines recommend antidepressants as treatments of fibromyalgia where tricyclics are often considered to have ...
Kim Lawson
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Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients [PDF]
Frontiers in Pharmacology, 2021 The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei +10 more
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Cytoprotective Effects of Melatonin Against Amitriptyline-Induced Toxicity in Isolated Rat Hepatocytes [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Shohreh Taziki +3 more
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Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study [PDF]
Cellular Physiology and Biochemistry, 2013 Background/Aims: Several recent studies revealed an accumulation of ceramide in bronchial, tracheal and intestinal epithelial cells of mice and patients with cystic fibrosis (CF). Normalization of ceramide concentrations in lungs of CF mice employing the
Lutz Nährlich +16 more
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Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae [PDF]
Scientific ReportsBronchial asthma is a chronic inflammatory disease with rising prevalence worldwide. Apart from the immunological role of the tricyclic antidepressant amitriptyline in bronchial asthma, there is emerging evidence that inhaled amitriptyline directly ...
Virag Klein +6 more
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High Concentrations of the Antidepressant Amitriptyline Activate and Desensitize the Capsaicin Receptor TRPV1 [PDF]
PharmaceuticalsBackground: A large number of patients suffer from neuropathic pain, and systemic therapy often remains ineffective while inducing severe side effects. Topical therapy with the TRPV1-agonist capsaicin is an established alternative, and the identification
Sebastian Pantke +7 more
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Amitriptyline and Imipramine [PDF]
British Journal of Psychiatry, 1964 John M. Hoenig
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Fullerene (C20) as a potential sensor for thermal and electrochemical detection of amitriptyline: A DFT study [PDF]
Journal of Chemistry Letters, 2020 In this research, amitriptyline adsorption on the surface of fullerene C20 was studied by density functional theory computations. The calculated adsorption energies showed amitriptyline interaction with C20 is experimentally possible. The negative values
Mohammad Reza Jalali Sarvestani +1 more
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Effect of amitriptyline on orthodontic tooth movement in rats: an experimental study [PDF]
Journal of Dental Research, Dental Clinics, Dental Prospects, 2020 Background. Orthodontic tooth movement (OTM) occurs in the alveolar bone; therefore, any condition affecting bone quality can alter OTM. This study aimed to evaluate the effect of amitriptyline on OTM in rats. Methods.
Mohammad Sadegh Ahmad Akhoundi +6 more
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Enhanced Amitriptyline Degradation by Electrochemical Activation of Peroxydisulfate: Mechanisms of Interfacial Catalysis and Mass Transfer. [PDF]
MoleculesWen T, Hu F, Yue Y, Li C, He Y, Ding J.
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