Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae [PDF]
Scientific ReportsBronchial asthma is a chronic inflammatory disease with rising prevalence worldwide. Apart from the immunological role of the tricyclic antidepressant amitriptyline in bronchial asthma, there is emerging evidence that inhaled amitriptyline directly ...
Virag Klein +6 more
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Veterinary Medicine and Science, 2021 Background There are limited studies on the utilization of analgesics in testudines. Management of pain in reptiles is by use of analgesics generally used in other vertebrate species.
Christopher M. Makau +3 more
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A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia [PDF]
Biomedicines, 2017 Fibromyalgia is a complex chronic condition characterized by pain, physical fatigue, sleep disorder and cognitive impairment. Evidence-based guidelines recommend antidepressants as treatments of fibromyalgia where tricyclics are often considered to have ...
Kim Lawson
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High Concentrations of the Antidepressant Amitriptyline Activate and Desensitize the Capsaicin Receptor TRPV1 [PDF]
PharmaceuticalsBackground: A large number of patients suffer from neuropathic pain, and systemic therapy often remains ineffective while inducing severe side effects. Topical therapy with the TRPV1-agonist capsaicin is an established alternative, and the identification
Sebastian Pantke +7 more
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Mechanistic Insights and Therapeutic Potential of the Antidepressant Amitriptyline against <i>Leishmania (Leishmania) amazonensis</i>. [PDF]
ACS OmegaMesquita JT +3 more
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THERAPEUTIC EFFECT OF AMITRIPTYLINE IN MANAGEMENT OF CHRONIC LOW BACK PAIN
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2008 BACKGROUND AND OBJECTIVE: Chronic low back pain because of common prevalence and economic burden is one of the important health and social problems of societies. There are different drugs and non drug treatment in approach to management of low back pain.
A Ahmadi Ahangar,, SR Hosseini
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Fullerene (C20) as a potential sensor for thermal and electrochemical detection of amitriptyline: A DFT study [PDF]
Journal of Chemistry Letters, 2020 In this research, amitriptyline adsorption on the surface of fullerene C20 was studied by density functional theory computations. The calculated adsorption energies showed amitriptyline interaction with C20 is experimentally possible. The negative values
Mohammad Reza Jalali Sarvestani +1 more
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Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models [PDF]
Korean Journal of Anesthesiology, 2019 Background The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline.
Yumi Kim +8 more
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Effect of amitriptyline on orthodontic tooth movement in rats: an experimental study [PDF]
Journal of Dental Research, Dental Clinics, Dental Prospects, 2020 Background. Orthodontic tooth movement (OTM) occurs in the alveolar bone; therefore, any condition affecting bone quality can alter OTM. This study aimed to evaluate the effect of amitriptyline on OTM in rats. Methods.
Mohammad Sadegh Ahmad Akhoundi +6 more
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Frontiers in Pharmacology, 2021 The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei +10 more
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