Results 1 to 10 of about 42,764 (213)

Cytoprotective Effects of Melatonin Against Amitriptyline-Induced Toxicity in Isolated Rat Hepatocytes [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Shohreh Taziki, Mohammad Reza Sattari, Siavoush Dastamalchi, Mohammad Ali Eghbal   +3 more
doaj   +4 more sources

A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia [PDF]

Biomedicines, 2017
Fibromyalgia is a complex chronic condition characterized by pain, physical fatigue, sleep disorder and cognitive impairment. Evidence-based guidelines recommend antidepressants as treatments of fibromyalgia where tricyclics are often considered to have ...
Kim Lawson
doaj   +3 more sources

Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae [PDF]

Scientific Reports
Bronchial asthma is a chronic inflammatory disease with rising prevalence worldwide. Apart from the immunological role of the tricyclic antidepressant amitriptyline in bronchial asthma, there is emerging evidence that inhaled amitriptyline directly ...
Virag Klein, Anna Michely, Paulina Hempel, Istvan Katona, Klaus Tenbrock, Christian Martin, Eva Verjans   +6 more
doaj   +2 more sources

Fullerene (C20) as a potential sensor for thermal and electrochemical detection of amitriptyline: A DFT study [PDF]

Journal of Chemistry Letters, 2020
In this research, amitriptyline adsorption on the surface of fullerene C20 was studied by density functional theory computations. The calculated adsorption energies showed amitriptyline interaction with C20 is experimentally possible. The negative values
Mohammad Reza Jalali Sarvestani, Zohreh Doroudi   +1 more
doaj   +1 more source

Effect of amitriptyline on orthodontic tooth movement in rats: an experimental study [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects, 2020
Background. Orthodontic tooth movement (OTM) occurs in the alveolar bone; therefore, any condition affecting bone quality can alter OTM. This study aimed to evaluate the effect of amitriptyline on OTM in rats. Methods.
Mohammad Sadegh Ahmad Akhoundi, Mahdiyeh Shaygan-Mehr, Mohammad Ali Keshvad, Shahroo Etemad Moghaddam, Mojgan Alaeddini, Ahmadreza Dehpour, Amir Hossein Mirhashemi   +6 more
doaj   +1 more source

Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models [PDF]

Korean Journal of Anesthesiology, 2019
Background The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline.
Yumi Kim, So Young Kwon, Hong Soo Jung, Yoo Jung Park, Yong Shin Kim, Jang Hyeok In, Jin Woo Choi, Jin A Kim, Jin Deok Joo   +8 more
doaj   +1 more source

Adverse drug reactions associated with amitriptyline - protocol for a systematic multiple-indication review and meta-analysis [PDF]

, 2020
Background: Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-thecounter products.
Brueckle, Maria-Sophie, Gerlach, Ferdinand M, Glasziou, Paul P, Gonzalez-Gonzalez, Ana Isabel, Harder, Sebastian, Muth, Christiane, Nguyen, Truc Sophia, Pilz, Maximilian, Seide, Svenja E, Thomas, Elizabeth T   +9 more
core   +1 more source

Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways

Respiratory Research, 2023
Introduction The standard therapy for bronchial asthma consists of combinations of acute (short-acting ß2-sympathomimetics) and, depending on the severity of disease, additional long-term treatment (including inhaled glucocorticoids, long-acting ß2 ...
Paulina Hempel, Virag Klein, Anna Michely, Svenja Böll, Annette D. Rieg, Jan Spillner, Till Braunschweig, Saskia von Stillfried, Norbert Wagner, Christian Martin, Klaus Tenbrock, Eva Verjans   +11 more
doaj   +1 more source

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients

Frontiers in Pharmacology, 2021
The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei, Jürgen Brockmöller, Werner Steimer, Konstanze Pischa, Stefan Leucht, Maria Kullmann, Ole Jensen, Typhaine Ouethy, Mladen Vassilev Tzvetkov, Mladen Vassilev Tzvetkov, Muhammad Rafehi   +10 more
doaj   +1 more source

Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa.

PLoS ONE, 2020
BackgroundInappropriate medication use is a major patient safety concern, especially for the elderly population. Amitriptyline is widely used in primary care in South Africa and a cross-sectional study found that amitriptyline was prescribed potentially ...
Renier Coetzee, Yasmina Johnson, Johan van Niekerk, Mosedi Namane   +3 more
doaj   +1 more source