Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients [PDF]
Frontiers in Pharmacology, 2021 The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei +10 more
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A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia [PDF]
Biomedicines, 2017 Fibromyalgia is a complex chronic condition characterized by pain, physical fatigue, sleep disorder and cognitive impairment. Evidence-based guidelines recommend antidepressants as treatments of fibromyalgia where tricyclics are often considered to have ...
Kim Lawson
doaj +3 more sources
Fullerene (C20) as a potential sensor for thermal and electrochemical detection of amitriptyline: A DFT study [PDF]
Journal of Chemistry Letters, 2020 In this research, amitriptyline adsorption on the surface of fullerene C20 was studied by density functional theory computations. The calculated adsorption energies showed amitriptyline interaction with C20 is experimentally possible. The negative values
Mohammad Reza Jalali Sarvestani +1 more
doaj +2 more sources
Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models [PDF]
Korean Journal of Anesthesiology, 2019 Background The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline.
Yumi Kim +8 more
doaj +2 more sources
Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae [PDF]
Scientific ReportsBronchial asthma is a chronic inflammatory disease with rising prevalence worldwide. Apart from the immunological role of the tricyclic antidepressant amitriptyline in bronchial asthma, there is emerging evidence that inhaled amitriptyline directly ...
Virag Klein +6 more
doaj +2 more sources
PLoS ONE, 2023 BackgroundHalf the US population uses drugs with anticholinergic properties. Their potential harms may outweigh their benefits. Amitriptyline is among the most frequently prescribed anticholinergic medicinal products, is used for multiple indications ...
Maria-Sophie Brueckle +9 more
doaj +2 more sources
High Concentrations of the Antidepressant Amitriptyline Activate and Desensitize the Capsaicin Receptor TRPV1 [PDF]
PharmaceuticalsBackground: A large number of patients suffer from neuropathic pain, and systemic therapy often remains ineffective while inducing severe side effects. Topical therapy with the TRPV1-agonist capsaicin is an established alternative, and the identification
Sebastian Pantke +7 more
doaj +2 more sources
Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline
Cellular Physiology and Biochemistry, 2016 Background/Aims: Several recent clinical studies revealed an accumulation of ceramide in bronchial epithelial cells of patients with cystic fibrosis (CF).
Constantin Adams +8 more
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The Journal of Headache and Pain, 2023 Objective The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis. Methods We report our methods and results following the Preferred Reporting Items for Systematic Reviews (PRISMA), by ...
C. Lampl +14 more
semanticscholar +1 more source
Comparison of Amitriptyline and US Food and Drug Administration–Approved Treatments for Fibromyalgia
JAMA Network Open, 2022 This systematic review and network meta-analysis compares amitriptyline with Food and Drug Administration–approved treatments for fibromyalgia related to sleep, fatigue, and health-related quality of life outcomes.
H. M. Farag +5 more
semanticscholar +1 more source